Výsledky vyhledávání - "rho-Associated Kinases/metabolism"

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells

Autor: Karim Bouzakri, Katharina Rickenbach, Caroline Arous, Michel Pinget, Bernhard Wehrle-Haller, Maria L. Mizgier

Publikováno v: Journal of Biological Chemistry, Vol. 295, No 49 (2020) pp. 16510-16528
The Journal of Biological Chemistry

Elevated levels of fasting insulin release and insufficient glucose-stimulated insulin secretion (GSIS) are hallmarks of diabetes. Studies have established cross-talk between integrin signaling and insulin activity, but more details of how integrin-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4063a6b9e04781fc7fe5d6ec0c61ec14
https://doi.org/10.1074/jbc.ra120.012957

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ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Autor: Rothschild, Pierre-Raphaël, Salah, Sawsen, Berdugo, Marianne, Gelize, Emmanuelle, Delaunay, Kimberley, Naud, Marie-Christine, Klein, Christophe, Moulin, Alexandre, Savoldelli, Michèle, Bergin, Ciara, Jeanny, Jean-Claude, Jonet, Laurent, Arsenijevic, Yvan, Behar-Cohen, Francine, Crisanti, Patricia

Publikováno v: Scientific reports, vol. 7, no. 1, pp. 8834
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩

In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2398ee2c24a38534d0cc0a09062c7f44
https://serval.unil.ch/resource/serval:BIB_BE7FCF2F7BE8.P001/REF.pdf

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γ-Actin regulates cell migration and modulates the ROCK signaling pathway

Autor: Eddy Pasquier, Peter W. Gunning, Christine Chaponnier, Sela T. Po'uha, Geraldine M. O'Neill, Michael S.Y. Shum, Maria Kavallaris

Publikováno v: FASEB Journal, Vol. 25, No 12 (2011) pp. 4423-33
FASEB journal : official publication of the Federation of American Societies for Experimental Biolog

Cell migration plays a crucial role in numerous cellular functions, and alterations in the regulation of cell migration are required for invasive transformation of a tumor cell. While the mechanistic process of actin-based migration has been well doc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba44783c5270252a718b8e82cddce7e5
https://archive-ouverte.unige.ch/unige:25621

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Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate

Autor: Christine Gerber-Wicht, U Lang, Miguel Frias, Richard W. James

Publikováno v: Cardiovascular Research, Vol. 82, No 2 (2009) pp. 313-323

AIMS: High-density lipoprotein (HDL) has been reported to have cardioprotective properties independent from its cholesterol transport activity. The influence of native HDL and reconstituted HDL (rHDL) on Stat3, the transcription factor playing an imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad57a35a15b58216e1db40448e318680
https://pubmed.ncbi.nlm.nih.gov/19151362

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Molecular aspects of intestinal radiation-induced fibrosis

Autor: Marie-Catherine Vozenin-Brotons, Philippe Morel, Pascal Gervaz

Publikováno v: Current Molecular Medicine, Vol. 9, No 3 (2009) pp. 273-280
Current Molecular Medicine
Current Molecular Medicine, 2009, 9 (3), pp.273-280. ⟨10.2174/156652409787847164⟩

Radiation therapy is a key component of the management of various pelvic tumors, including prostate, gynecological, and anorectal carcinomas. Unfortunately, normal tissues located in the vicinity of target organs are radiosensitive, and long-term can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e724d970daa2f45aa3f5bc6c342be3
https://archive-ouverte.unige.ch/unige:19531

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Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis

Autor: Francesco Aulicino, Maria Pia Cosma, Ilda Theka, Francesco Sottile

Publikováno v: Sottile, F, Aulicino, F, Theka, I & Cosma, M P 2016, ' Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis ', Scientific Reports, vol. 6, 36863 . https://doi.org/10.1038/srep36863
Recercat. Dipósit de la Recerca de Catalunya
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Scientific Reports

Homotypic and heterotypic cell-to-cell fusion are key processes during development and tissue regeneration. Nevertheless, aberrant cell fusion can contribute to tumour initiation and metastasis. Additionally, a form of cell-in-cell structure called e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c0fc33eb290e5ba861817319a82238

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