Zobrazeno 1 - 10
of 579
pro vyhledávání: '"rhGH"'
Autor:
Xiaozhen Huang, Hong Chen, Huakun Shangguan, Wenyong Wu, Zhuanzhuan Ai, Zhifeng Chen, Ruimin Chen
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundIsolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-lik
Externí odkaz:
https://doaj.org/article/48b49923f03845f89fd8209d571ba1a4
Autor:
Agim Gjikopulli, Sonila Tomori, Donjeta Bali, Paskal Cullufi, Laurant Kollcaku, Mirela Tabaku, Anila Babameto
Publikováno v:
International Journal of Biomedicine, Vol 14, Iss 2, Pp 275-281 (2024)
Background: There is no doubt that the use of rhGH in patients with TS brings satisfactory results regarding the improvement of height growth, realizing the improvement of the final adult height. This study aimed to evaluate the influence of the type
Externí odkaz:
https://doaj.org/article/58e57ac111d3459c8ed2e23469d6c612
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Objective To characterize the phenotype spectrum, diagnosis, and response to growth‐promoting therapy in patients with ACAN variants causing familial short stature. Methods Three families with ACAN variants causing short stature were repor
Externí odkaz:
https://doaj.org/article/2d66a09de1d64d4788bdf434211a8176
Publikováno v:
Pharmacogenomics and Personalized Medicine, Vol Volume 16, Pp 1091-1096 (2023)
Yi-Can Yang,1 Qiong Tang,1 Li-Juan Yan,1 Shi-Bin Zhang,2 Xiao-Min Ye,1 Dai Gong,1 Li Zou,1 Xiang-Lan Wen1 1Department of Children Health Care Center, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou City, Huna
Externí odkaz:
https://doaj.org/article/9186903ac053446899c4fc87e716a3ff
Autor:
Hong Chen, Suping Zhang, Yunteng Sun, Jiao Chen, Ke Yuan, Ying Zhang, Xiaohong Yang, Xiangquan Lin, Ruimin Chen
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-14 (2023)
Abstract Objective Heterozygous loss-of-function variants in the NPR2 gene cause short stature with nonspecific skeletal abnormalities and account for about 2 ~ 6% of idiopathic short stature. This study aimed to analyze and identify pathogenic varia
Externí odkaz:
https://doaj.org/article/33a852a5a6db46ac8de1ade63eba0085
Autor:
Patrizia Bruzzi, Silvia Vannelli, Emanuela Scarano, Natascia Di Iorgi, Maria Parpagnoli, MariaCarolina Salerno, Marco Pitea, Maria Elisabeth Street, Andrea Secco, Adolfo Andrea Trettene, Malgorzata Wasniewska, Nicola Corciulo, Gianluca Tornese, Maria Felicia Faienza, Maurizio Delvecchio, Simona Filomena Madeo, Lorenzo Iughetti
Publikováno v:
Endocrine Connections, Vol 12, Iss 7, Pp 1-10 (2023)
Objective: This Italian survey aims to evaluate real-life long-term efficac y and safety of recombinant human growth hormone (rhGH) therapy in children wit h short stature homeobox-containing gene deficiency disorders (SHOX-D) and to id entify potent
Externí odkaz:
https://doaj.org/article/82d6fe2bd57c403b9090fe00f9ba81ab
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundVariants in membrane-bound transcription factor peptidase, site 1 (MBTPS1) gene, can result in clinically rare spondyloepiphyseal dysplasia of Kondo-fu type (OMIM #618392, SEDKF), Silver–Russell syndrome, and CAOP (cataract, alopecia, ora
Externí odkaz:
https://doaj.org/article/45a7496bf6fc4aa78d73c09e3edde57a
Autor:
Zhouhong Jiang, Xuefeng Chen, Guanping Dong, Yin Lou, Jianping Zhang, Xinran Cheng, Jiayan Pan, Wei Liao, Jinzhun Wu, Xiaodong Huang, Xianjiang Jin, Deyun Liu, Ting Zeng, Shunye Zhu, Qin Dong, Xiaoming Luo, Dan Lan, Lizhi Cao, Xingxing Zhang, Jing Liu, Mingjuan Dai, Manyan Zhang, Li Liu, Junhua Dong, Dongmei Zhao, Shaoqing Ni, Junfen Fu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Objective: Polyethylene glycol recombinant human growth hormone (PEG-rhGH, Jintrolong®) is the first long-acting rhGH preparation that is approved to treat children with growth hormone deficiency (GHD) in China. Clinical experience with dose selecti
Externí odkaz:
https://doaj.org/article/e9823f9784f543bc88d9bf8455288e57
Autor:
Natascia Di Iorgi, Giovanni Morana, Marco Cappa, Ludovico D’Incerti, Maria Luisa Garrè, Armando Grossi, Lorenzo Iughetti, Patrizia Matarazzo, Maria Parpagnoli, Gabriella Pozzobon, Mariacarolina Salerno, Iacopo Sardi, Malgorzata Gabriela Wasniewska, Stefano Zucchini, Andrea Rossi, Mohamad Maghnie
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundGrowth hormone deficiency (GHD) is the first and most common endocrine complication in pediatric brain tumor survivors (BTS). GHD can occur due to the presence of the tumor itself, surgery, or cranial radiotherapy (CRT).AimsThis study aimed
Externí odkaz:
https://doaj.org/article/f5343cda23ee4160b56c1db73ce8b717
Autor:
Wei Wu, Juan Zhou, Chuandong Wu, Qian Zhou, Xiaoyu Li, Yanlin Zhang, Conglin Zuo, Jun Yin, Ling Hou, Shuyang Wang, Hongyang Gao, Tianhong Luo, Lei Jin, Enhong Zhong, Yingwu Wang, Xiaoping Luo
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Jintrolong® is a long-acting PEGylated recombinant human growth hormone (PEG-rhGH) developed for weekly injection in patients with pediatric growth hormone deficiency (PGHD). Although PEG modification of therapeutic proteins is generally considered
Externí odkaz:
https://doaj.org/article/97e8687a3d664d16bf328b4525f3edab