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Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

Autor: Prashant Kesharwani, Harish Rajak, Bapi Gorain, Vijay K. Patel, Talha Jawaid, Mehnaz Kamal, Ekta Shirbhate, Jaiprakash Pandey

Publikováno v: Pharmacological Reports

Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin-angiotensin-aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa2a5a20666dff7a13418de489f4f0b
http://europepmc.org/articles/PMC8236094

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Treatment Options Available for COVID-19 and an Analysis on Possible Role of Combination of rhACE2, Angiotensin (1-7) and Angiotensin (1-9) as Effective Therapeutic Measure

Autor: Gulam Mustafa, Nasrin Nasrin, Shahnawaz Muslim, Shambhu Kumar Singh, Faisal Obaid Alotaibi, Izhar Alam, Geeta Prasad

Publikováno v: SN Comprehensive Clinical Medicine
Sn Comprehensive Clinical Medicine

Corona virus disease (COVID-19), caused by SARS-CoV-2, is rapidly spreading all around the world and is posing a threat to mankind. Since SARS-CoV-2 is a novel virus, little is known about it and no effective drug is available for its treatment. Whil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b968086aaae5b3aca9507f4dc586ba03
https://doi.org/10.1007/s42399-020-00407-9

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An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension

Autor: Simon, Marc A, Hanrott, Kate, Budd, David C, Torres, Fernando, Grünig, Ekkehard, Escribano-Subias, Pilar, Meseguer, Manuel L, Halank, Michael, Opitz, Christian, Hall, David A, Hewens, Deborah, Powley, William M, Siederer, Sarah, Bayliffe, Andrew, Lazaar, Aili L, Cahn, Anthony, Rosenkranz, Stephan

Publikováno v: Pulmonary circulation, vol 12, iss 1

Preclinical and early clinical studies suggest that angiotensin-converting enzyme type 2 activity may be impaired in patients with pulmonary arterial hypertension (PAH); therefore, administration of exogenous angiotensin-converting enzyme type 2 (ACE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5786579ef86f73c5fdbc6fba6f93dbe1
https://escholarship.org/uc/item/4k2476jb

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Association and pharmacological synergism of the triple drug therapy baricitinib/remdesivir/rhACE2 for the management of COVID-19 infection

Autor: Francesco Ferrara, Antonio Vitiello

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology

A massive vaccination campaign against the global COVID-19 pandemic caused by SARS-CoV-2 virus began worldwide in January 2021. However, studies continue to investigate the most effective and safe drug therapies to manage the various stages of viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43b249914d2f5d26946699ac73aa3b9
https://pubmed.ncbi.nlm.nih.gov/34669002

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Akademický článek

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Effects of Recombinant Human Angiotensin-Converting Enzyme 2 on Response to Acute Hypoxia and Exercise: A Randomised, Placebo-Controlled Study

Autor: Dominik Berliner, Aili L. Lazaar, Anthony Cahn, William Powley, Jens M. Hohlfeld, Deborah Hewens, David A. Hall, Sarah Siederer, Kate E Hanrott, Philipp Badorrek, Rhena Eames, David C. Budd

Publikováno v: Pulmonary Therapy

Introduction Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin-angiotensin system (RAS) that has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). Enhancing ACE2 activity using GSK2586881, a recombin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aef9cb8410100a3b2f89c428aa437f3
https://pubmed.ncbi.nlm.nih.gov/34189703

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New therapeutic approaches against COVID-19: an approach that must be multidimensional and dynamic to counter the complications of this disease

Autor: Labelle, Jean-Philippe

The recent pandemic caused by the SARS-CoV2 has brought the world to a halt. The damages done to the epithelial cells from the lungs by the virus and the immune system rapidly deteriorate in an ARDS in severe and critically ill patients. The only ava

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433102d692040b04e556aa3581c694f4

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Angiotensin converting enzyme-2 as therapeutic target in COVID-19

Autor: Neda Roshanravan, Samad Ghaffari, Mehdi Hedayati

Publikováno v: Diabetes & Metabolic Syndrome
Diabetes & Metabolic Syndrome: Clinical Research & Reviews

The pandemic of coronavirus disease 2019 (COVID-19) is a global health emergency that poses a significant threat to world people’s health. This outbreak causes major challenges to healthcare systems. Given the lack of effective treatments or vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0e12d9776e5d5ced14fbc9f4aa9028
https://pubmed.ncbi.nlm.nih.gov/32428864

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