Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain

Autor: Mei, Yuheng ¹, Yu, Zhihui ¹, Gong, Yue, Meng, Runze, Ma, Xican, Li, Hu, Li, Jiayu, Jiang, Jiandong, Peng, Zonggen, Li, Yinghong ^⁎, Song, Danqing ^⁎

Publikováno v: In Bioorganic Chemistry January 2025 154

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The Use of Reversible Covalent Bonding and Induced Intramolecularity to Achieve Selectivity and Rate Acceleration in Organic Reactions

Autor: Worthy, Amanda D.

Thesis advisor: Kian L. Tan
Chapter 1. Catalytic directing group, I, which was designed with the ability to form a reversible covalent bond with a substrate and bind a metal, was shown to direct the hydroformylation of allylic amines. The effici

Externí odkaz: http://hdl.handle.net/2345/3162

Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain.

Autor: Mei Y; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Yu Z; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Gong Y; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Meng R; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Ma X; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Li H; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Li J; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Jiang J; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Peng Z; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China., Li Y; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: liyinghong@imb.pumc.edu.cn., Song D; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: songdanqing@imb.pumc.edu.cn.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Dec 19; Vol. 154, pp. 108086. Date of Electronic Publication: 2024 Dec 19.