Zobrazeno 1 - 10
of 623
pro vyhledávání: '"retroelement"'
Autor:
Nicholas Dopkins, Tongyi Fei, Stephanie Michael, Nicholas Liotta, Kejun Guo, Kaylee L. Mickens, Brad S. Barrett, Matthew L. Bendall, Stephanie M. Dillon, Cara C. Wilson, Mario L. Santiago, Douglas F. Nixon
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105133- (2024)
Summary: Background: Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the human genome. Our previous studies of the interferome in the gut suggest
Externí odkaz:
https://doaj.org/article/77bd4000351b463188eba2fb539d30cc
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The development of age-associated diseases is related to the accumulation of senescent cells in the body. These are old non-functional cells with impaired metabolism, which are unable to divide. Such cells are also resistant to programmed cell death
Externí odkaz:
https://doaj.org/article/9f63bb7597f6407792f32ec2c82184ca
SCIFER: approach for analysis of LINE-1 mRNA expression in single cells at a single locus resolution
Autor:
Emily C. Stow, Melody Baddoo, Alexis J. LaRosa, Dawn LaCoste, Prescott Deininger, Victoria Belancio
Publikováno v:
Mobile DNA, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Background Endogenous expression of L1 mRNA is the first step in an L1-initiated mutagenesis event. However, the contribution of individual cell types to patterns of organ-specific L1 mRNA expression remains poorly understood, especially at
Externí odkaz:
https://doaj.org/article/eb7e2933ba034fd3a88cf17d82998512
Tentaclins—A Novel Family of Phage Receptor-Binding Proteins That Can Be Hypermutated by DGR Systems
Autor:
Ivan K. Baykov, Artem Y. Tikunov, Igor V. Babkin, Valeria A. Fedorets, Elena V. Zhirakovskaia, Nina V. Tikunova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17324 (2023)
Diversity-generating retroelements (DGRs) are prokaryotic systems providing rapid modification and adaptation of target proteins. In phages, the main targets of DGRs are receptor-binding proteins that are usually parts of tail structures and the vari
Externí odkaz:
https://doaj.org/article/2ea33ee5856144ff8e47a9168bd3d473
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Publikováno v:
Pathogens, Vol 12, Iss 8, p 1056 (2023)
The abundant and widely distributed deermice Peromyscus leucopus and P. maniculatus are important reservoirs for several different zoonotic agents in North America. For the pathogens they persistently harbor, these species are also examples of the ph
Externí odkaz:
https://doaj.org/article/77332c18665a4377880d1c56ed64bfbf
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 242-252 (2021)
Puberty is the gateway to adult reproductive competence, encompassing a suite of complex, integrative, and coordinated changes in neuroendocrine functions. However, the regulatory mechanisms of transcriptional reprogramming in the arcuate nucleus (AR
Externí odkaz:
https://doaj.org/article/0d0122c46e9843cda2ac9e09877f5c00
Akademický článek
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Autor:
Holly A. Rutherford, Amy Clarke, Emily V. Chambers, Jessica J. Petts, Euan G. Carson, Hannah M. Isles, Alejandra Duque-Jaramillo, Stephen A. Renshaw, Jean-Pierre Levraud, Noémie Hamilton
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Endogenous retroviruses (ERVs) are fossils left in our genome from retrovirus infections of the past. Their sequences are part of every vertebrate genome and their random integrations are thought to have contributed to evolution. Although ERVs are ma
Externí odkaz:
https://doaj.org/article/41b7b9994ecb41a683d8d684f5ce4a0b