Zobrazeno 1 - 10
of 539
pro vyhledávání: '"retinal organoids"'
Publikováno v:
Organoids, Vol 3, Iss 3, Pp 148-164 (2024)
In zebrafish and various mammalian species, HB-EGF has been shown to promote Müller glia proliferation and activation of repair mechanisms that have not been fully investigated in human retina. In the current study, 70- to 90-day-old human retinal o
Externí odkaz:
https://doaj.org/article/3a7e7adf34094f029439ca6e01e48c65
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 382-386 (2024)
Retinal organoids are three-dimensional (3D) microscopic tissues that are induced and differentiated from stem cells or progenitor cells in vitro and have a highly similar structure to the retina. With the optimization and development of 3D retinal c
Externí odkaz:
https://doaj.org/article/722933de0b7742a1bffa10802f75c502
Autor:
Chunwen Duan, Chengcheng Ding, Xihao Sun, Shengru Mao, Yuqin Liang, Xinyu Liu, Xiaoyan Ding, Jiansu Chen, Shibo Tang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1-associated retinal degeneration is not fully understood. Besi
Externí odkaz:
https://doaj.org/article/ba74c82df0bc43448614ae57b83e48c7
Autor:
Margaret T. Ho, Kotoe Kawai, Dhana Abdo, Lacrimioara Comanita, Arturo Ortin-Martinez, Yui Ueno, Emily Tsao, Azam Rastgar-Moghadam, Chang Xue, Hong Cui, Valerie A. Wallace, Molly S. Shoichet
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic cargo. However, previo
Externí odkaz:
https://doaj.org/article/adf82bd9d98a46a19caf66f82f4d65a4
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Background The CRX-associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. However, based on reported human patient cases and studies with mouse models, it is hard to confirm the specif
Externí odkaz:
https://doaj.org/article/17b6c0f08abc40a3a5f426287f6775eb
Autor:
Almaqdad Alsalloum, Ekaterina Gornostal, Natalia Mingaleva, Roman Pavlov, Ekaterina Kuznetsova, Ekaterina Antonova, Aygun Nadzhafova, Daria Kolotova, Vitaly Kadyshev, Olga Mityaeva, Pavel Volchkov
Publikováno v:
Cells, Vol 13, Iss 20, p 1706 (2024)
Inherited retinal diseases (IRDs) represent a diverse group of genetic disorders leading to progressive degeneration of the retina due to mutations in over 280 genes. This review focuses on the various methodologies for the preclinical characterizati
Externí odkaz:
https://doaj.org/article/d7b027db114c4637b571ba9ee7dd06da
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/6055cfcf8d684f30b057d23a95fd74f5
Autor:
Sihyung Lee, Jungwoo Han, Jinyoung Yang, Jungmook Lyu, Hyosong Park, Jihong Bang, Yeji Kim, Hunsoo Chang, Taekwann Park
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8925 (2024)
This study investigated the therapeutic effects of exosomes derived from human-induced pluripotent stem cell (hiPSC)-derived retinal organoids (ROs) on corneal epithelial wound healing. Exosomes were isolated from the culture medium of the hiPSC-deri
Externí odkaz:
https://doaj.org/article/8b552ae2dc0644709b37978ed0c9b33a
Autor:
Hyo Song Park, Ji-Hong Bang, Wook Hyun Jung, Jin Young Yang, Hee Jeong Shin, Ji-Hye Son, Jung Woo Han, Si Hyung Lee, Kyung Hwun Chung, Kyunggon Kim, Hun Soo Chang, Tae Kwann Park
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8011 (2024)
Human retinal organoids (ROs) have emerged as valuable tools for studying retinal development, modeling human retinal diseases, and screening drugs. However, their application is limited primarily due to time-intensive generation, high costs, and low
Externí odkaz:
https://doaj.org/article/a024e157be5946cbab478f5ab4cea0f0
Autor:
David Atac, Kevin Maggi, Silke Feil, Jordi Maggi, Elisa Cuevas, Jane C. Sowden, Samuel Koller, Wolfgang Berger
Publikováno v:
Cells, Vol 13, Iss 13, p 1142 (2024)
The proneural transcription factor atonal basic helix–loop–helix transcription factor 7 (ATOH7) is expressed in early progenitors in the developing neuroretina. In vertebrates, this is crucial for the development of retinal ganglion cells (RGCs),
Externí odkaz:
https://doaj.org/article/e455fd37ba5e41c2a0ffbef85d36e9cf