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pro vyhledávání: '"retargeted integration"'
Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 51-67 (2021)
To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptid
Externí odkaz:
https://doaj.org/article/11b9a0cd871e48e387d597087364a932
Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 51-67 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 51-67 (2021)
To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da5e803512b23e94334baf48cd0543
https://pubmed.ncbi.nlm.nih.gov/34553002
https://pubmed.ncbi.nlm.nih.gov/34553002
Autor:
Sofie Vets, Jan De Rijck, Christian Brendel, Manuel Grez, Frederic Bushman, Zeger Debyser, Rik Gijsbers
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Retrovirus-based vectors are commonly used as delivery vehicles to correct genetic diseases because of their ability to integrate new sequences stably. However, adverse events in which vector integration activates proto-oncogenes, leading to clonal e
Externí odkaz:
https://doaj.org/article/50d4dcd6112d4ddc83add21019097193
Akademický článek
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Autor:
Zeger Debyser, Jan De Rijck, Christian Brendel, Frederic D. Bushman, Rik Gijsbers, Manuel Grez, Sofie Vets
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy — Nucleic Acids; Vol 2
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Molecular Therapy — Nucleic Acids; Vol 2
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Retrovirus-based vectors are commonly used as delivery vehicles to correct genetic diseases because of their ability to integrate new sequences stably. However, adverse events in which vector integration activates proto-oncogenes, leading to clonal e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c763f7ee87df94c7dbae75883bbdf1d
https://doi.org/10.1038/mtna.2013.4
https://doi.org/10.1038/mtna.2013.4
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.