Detailed analysis of Mdivi-1 effects on complex I and respiratory supercomplex assembly

Autor: Nico Marx, Nadine Ritter, Paul Disse, Guiscard Seebohm, Karin B. Busch

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract Several human diseases, including cancer and neurodegeneration, are associated with excessive mitochondrial fragmentation. In this context, mitochondrial division inhibitor (Mdivi-1) has been tested as a therapeutic to block the fission-rela

Externí odkaz: https://doaj.org/article/13b8eb4c4627437394a757350780e95c

Comparative analysis of CI- and CIV-containing respiratory supercomplexes at single-cell resolution

Autor: Fabio Bertan, Lena Wischhof, Enzo Scifo, Mihaela Guranda, Joshua Jackson, Anaïs Marsal-Cots, Antonia Piazzesi, Miriam Stork, Michael Peitz, Jochen Herbert Martin Prehn, Dan Ehninger, Pierluigi Nicotera, Daniele Bano

Publikováno v: Cell Reports: Methods, Vol 1, Iss 1, Pp 100002- (2021)

Summary: Mitochondria sustain the energy demand of the cell. The composition and functional state of the mitochondrial oxidative phosphorylation system are informative indicators of organelle bioenergetic capacity. Here, we describe a highly sensitiv

Externí odkaz: https://doaj.org/article/5ffa9e84f149453fb79210c87a25f6ea

Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48

Autor: Moreno-Beltrán, Blas, Guerra-Castellano, Alejandra, Díaz-Quintana, Antonio, Del Conte, Rebecca, García-Mauriño, Sofía M., Díaz-Moreno, Sofía, González-Arzola, Katiuska, Santos-Ocaña, Carlos, Velázquez-Campoy, Adrián, De la Rosa, Miguel A., Turano, Paola, Díaz-Moreno, Irene

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2017 Apr 01. 114(15), E3041-E3050.

Externí odkaz: https://www.jstor.org/stable/26480865

Organization of the Respiratory Supercomplexes in Cells with Defective Complex III: Structural Features and Metabolic Consequences

Autor: Michela Rugolo, Claudia Zanna, Anna Maria Ghelli

Publikováno v: Life, Vol 11, Iss 4, p 351 (2021)

The mitochondrial respiratory chain encompasses four oligomeric enzymatic complexes (complex I, II, III and IV) which, together with the redox carrier ubiquinone and cytochrome c, catalyze electron transport coupled to proton extrusion from the inner

Externí odkaz: https://doaj.org/article/dddb348bed0044ccbeac99a105e3ab0b

Intra-cellular to inter-organ mitochondrial communication in striated muscle in health and disease

Autor: Neoma T Boardman, Giulia Trani, Marco Scalabrin, Vanina Romanello, Rob C I Wüst

Publikováno v: Endocrine Reviews. The Endocrine Society
Boardman, N T, Trani, G, Scalabrin, M, Romanello, V & Wüst, R C I 2023, ' Intra-cellular to inter-organ mitochondrial communication in striated muscle in health and disease ', Endocrine Reviews . https://doi.org/10.1210/endrev/bnad004

Mitochondria sense both biochemical and energetic input in addition to communicating signals regarding the energetic state of the cell. Increasingly, these signaling organelles are recognized as key for regulating different cell functions. This revie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfa0c8eca8e8d63f584351b758146ae
https://research.vu.nl/en/publications/062aa302-98b6-42ee-9c54-b6827105e2df