Zobrazeno 1 - 10
of 336
pro vyhledávání: '"repurposing drugs"'
Publikováno v:
BioChem, Vol 4, Iss 3, Pp 236-251 (2024)
Pulmonary arterial hypertension (PAH) is a progressive disorder caused by the narrowing of small blood vessels in the lungs, which, in the absence of therapies, leads to right heart failure and premature death. No cure for this devastating disorder i
Externí odkaz:
https://doaj.org/article/1e8fa4b692574c09a43cf672a8037c6c
Autor:
Ming-Yung Chou, Shoei-Yn Lin-Shiau
Publikováno v:
Journal of Dental Sciences, Vol 19, Iss 3, Pp 1486-1498 (2024)
Background/purpose: Explorations of novel regimens enhancing efficacy and selectivity of chemotherapeutic agents are urgent to solve the problems of cancer therapy. This study aimed to explore synergistic anticancer effects of novel regimens of phyto
Externí odkaz:
https://doaj.org/article/177a9da68df54f42a58cdc0e65f04557
Autor:
Luis A. Flores-López, Ignacio De la Mora-De la Mora, Claudia M. Malagón-Reyes, Itzhel García-Torres, Yoalli Martínez-Pérez, Gabriela López-Herrera, Gloria Hernández-Alcántara, Gloria León-Avila, Gabriel López-Velázquez, Alberto Olaya-Vargas, Saúl Gómez-Manzo, Sergio Enríquez-Flores
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1295 (2024)
T-cell acute lymphoblastic leukemia (T-ALL) is a challenging childhood cancer to treat, with limited therapeutic options and high relapse rates. This study explores deamidated triosephosphate isomerase (dTPI) as a novel therapeutic target. We hypothe
Externí odkaz:
https://doaj.org/article/b5729f43f091488fb264b0a8adec80dc
Publikováno v:
Applied Biological Chemistry, Vol 66, Iss 1, Pp 1-48 (2023)
Abstract COVID-19 has been a major global health concern for the past three years, and currently we are still experiencing coronavirus patients in the following years. The virus, known as SARS-CoV-2, shares a similar genomic identity with previous vi
Externí odkaz:
https://doaj.org/article/d72d9e9ad1814b91ac33fadba026e704
Publikováno v:
Research and Reports in Tropical Medicine, Vol Volume 14, Pp 61-85 (2023)
Thalia Pacheco-Fernandez,1,* Hannah Markle,1,* Chaitenya Verma,2 Ryan Huston,2,3 Sreenivas Gannavaram,1 Hira L Nakhasi,1 Abhay R Satoskar2,3 1Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Resear
Externí odkaz:
https://doaj.org/article/fdee9c0a038340b7af8fc8a6d7f869c6
Autor:
Michaela Hörner, Sandy Popp, Julien Branchu, Giovanni Stevanin, Frédéric Darios, Stephan Klebe, Janos Groh, Rudolf Martini
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
We have previously demonstrated that neuroinflammation by the adaptive immune system acts as a robust and targetable disease amplifier in a mouse model of Spastic Paraplegia, type 11 (SPG11), a complicated form of Hereditary Spastic Paraplegia (HSP).
Externí odkaz:
https://doaj.org/article/b3030858c55f4bb4871901a5455dc32c
Publikováno v:
Journal of Dental Sciences, Vol 17, Iss 4, Pp 1796-1801 (2022)
Background/purpose: Porphyromonas gingivalis (P.g.) played a keystone pathogen not only in initiation and progression of periodontitis but also as a risk factor involved in systemic diseases (Alzheimer’s disease, cancers, diabetes, osteoporosis etc
Externí odkaz:
https://doaj.org/article/01d88abcc5ba456486dc1862ca10a979
Autor:
Debora Collotta, Laura Lucarini
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/d31a823835954fd8a8fc89c28fdadecc
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 212 (2024)
The potential benefits of drug repurposing have gained attention as an alternative to developing de novo drugs. The potential of using central nervous system (CNS) drugs as anticancer drugs has been explored in several types of human cancers, such as
Externí odkaz:
https://doaj.org/article/336063b5547b4981a62b478679ba8a0e
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