Zobrazeno 1 - 10
of 20 074
pro vyhledávání: '"repurposing"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 4153-4182 (2024)
Mario Jug,1 Flavia Laffleur,2 Gioconda Millotti3 1Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, 10 000, Croatia; 2Department of Pharmaceutical Technology, Institute of Pharmacy, Center fo
Externí odkaz:
https://doaj.org/article/3c5fb3b76fee49788440620a791a140a
Autor:
Renato Kulakowski Corá, Gabriela Prado Paludo, Jéssica Andrade Paes, Henrique Bunselmeyer Ferreira
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Visceral cestodiases, like cysticercoses and echinococcoses, are caused by cystic larvae from parasites of the Cestoda class and are endemic or hyperendemic in many areas of the world. Current therapeutic approaches for these diseases are co
Externí odkaz:
https://doaj.org/article/a4d463eda53446d09b3b56a82df9ce7a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins, which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB-toxin with ADP-ribosyltranferase activity. C2 toxin possesses two
Externí odkaz:
https://doaj.org/article/638fda21750d43c9b0f8a3f05ef59eb4
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Background Drugs targeting disease causal genes are more likely to succeed for that disease. However, complex disease causal genes are not always clear. In contrast, Mendelian disease causal genes are well-known and druggable. Here, we seek
Externí odkaz:
https://doaj.org/article/778716eddc6d422cb7f374abc954f1e5
Autor:
Farid A. Badria, Abdullah A. Elgazar
Publikováno v:
Clinical Phytoscience, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Background Obstructive sleep apnea (OSA) is one of the foremost potential severe disorders, with frequent episodes of complete or partial obstructions of the upper airway during sleep. Therefore, several attempts to find an effective pharmac
Externí odkaz:
https://doaj.org/article/40dfeaeddb0445b7835c34ad17ca3150
Autor:
Hongtao Liu, Siqi Li, Le Deng, Zhenxu Shi, Chenxiao Jiang, Jingyan Shu, Yuan Liu, Xuming Deng, Jianfeng Wang, Zhimin Guo, Jiazhang Qiu
Publikováno v:
Engineering, Vol 39, Iss , Pp 180-193 (2024)
Infections caused by intracellular bacterial pathogens are difficult to treat since most antibiotics have low cell permeability and undergo rapid degradation within cells. The rapid development and dissemination of antimicrobial–resistant strains h
Externí odkaz:
https://doaj.org/article/94abbaaf59e5416ea96fd8e5c5a2e8f1
Autor:
Giovanni Buccioli, Carolina Testa, Emanuela Jacchetti, Pietro Pinoli, Stephana Carelli, Stefano Ceri, Manuela T. Raimondi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Statins, widely used cardiovascular drugs that lower cholesterol by inhibiting HMG-CoA reductase, have been increasingly recognized for their potential anticancer properties. This study elucidates the underlying mechanism, revealing that sta
Externí odkaz:
https://doaj.org/article/0c1f53cca6b34826820d8f66486621c7
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-20 (2024)
Abstract Background Delirium and Alzheimer's disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing
Externí odkaz:
https://doaj.org/article/f0549f6d2e3445c6a4f4805b56679577
Autor:
Reaz Ahmmed, Md. Bayazid Hossen, Alvira Ajadee, Sabkat Mahmud, Md. Ahad Ali, Md. Manir Hossain Mollah, Md. Selim Reza, Mohammad Amirul Islam, Md. Nurul Haque Mollah
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, n
Externí odkaz:
https://doaj.org/article/8a2ec485c21f4475814d5c984ff4bb1d
Autor:
Valentina Piastra, Federica Ganci, Andrea Sacconi, Angelina Pranteda, Matteo Allegretti, Roberta Bernardini, Martina Serra, Barbara Lupo, Emanuela Dell’Aquila, Gianluigi Ferretti, Edoardo Pescarmona, Armando Bartolazzi, Giovanni Blandino, Livio Trusolino, Gianluca Bossi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related deaths worldwide, with a survival rate near to 10% when diagnosed at an advanced stage. Hence, the identification of ne
Externí odkaz:
https://doaj.org/article/536b2932e0ac43d4922bd78ef035bbe1