Zobrazeno 1 - 10
of 468
pro vyhledávání: '"replication defective"'
Autor:
En Zhang, Yong Ke, Weihong Ran, Yu Zhang, Ruihang Li, Xinkui Fang, Lei Wang, Baohong Zhang, Tao Sun
Publikováno v:
Advanced Science, Vol 11, Iss 47, Pp n/a-n/a (2024)
Abstract The goal of the next‐generation COVID‐19 vaccine is to provide rapid respiratory tract protection with a single dose. Circulating antibodies do not protect the olfactory mucosa from viral infection, necessitating localized mucosal immuni
Externí odkaz:
https://doaj.org/article/db512b1e1d3e4fbe86388a46570b99d5
Autor:
Munal B. Kandel, Gerald Z. Zhuang, William F. Goins, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Wai-Meng Kwok, Roy C. Levitt, Konstantinos D. Sarantopoulos
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Chronic pain is common and inadequately treated, making the development of safe and effective analgesics a high priority. Our previous data indicate that carbonic anhydrase-8 (CA8) expression in dorsal root ganglia (DRG) mediates analgesia via inhibi
Externí odkaz:
https://doaj.org/article/3621c8f032f6429ba118a169c8a8463e
Publikováno v:
Viruses, Vol 16, Iss 9, p 1476 (2024)
Herpes simplex virus (HSV) has coevolved with Homo sapiens for over 100,000 years, maintaining a tenacious presence by establishing lifelong, incurable infections in over half the human population. As of 2024, an effective prophylactic or therapeutic
Externí odkaz:
https://doaj.org/article/6aea9fae582f4611907357b2a8b6e431
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
African swine fever virus (ASFV) is a large DNA virus belonging to the Asfarviridae family that damages the immune system of pigs, resulting in the death or slaughter of millions of animals worldwide. Recent modern techniques in ASFV vaccination have
Externí odkaz:
https://doaj.org/article/18fb8785089843ec8606071a178b1b53
Autor:
Phoom Narongkiatikhun, Kajohnsak Noppakun, Romanee Chaiwarith, Poramed Winichakoon, Surachet Vongsanim, Yuttitham Suteeka, Karn Pongsuwan, Prit Kusirisin, Nuttanun Wongsarikan, Kanda Fanhchaksai, Chantana Khamwan, Dararat Dankai, Vuddhidej Ophascharoensuk
Publikováno v:
Vaccines, Vol 11, Iss 4, p 715 (2023)
Background: Vaccines that prevent SARS-CoV-2 infection are considered the most promising approach to modulating the pandemic. There is scarce evidence on the efficacy and safety of different vaccine prime-boost combinations in MHD patients since most
Externí odkaz:
https://doaj.org/article/312472deea724cadb6217a56c05db25f
Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication
Publikováno v:
Viruses, Vol 14, Iss 5, p 869 (2022)
We previously isolated an HSV-1 mutant, KOS-NA, that contains two non-synonymous mutations in UL39. One of the mutations, resulting in an R950H amino acid substitution in ICP6, renders KOS-NA severely neuro-attenuated and significantly reduces HSV-1
Externí odkaz:
https://doaj.org/article/ba2e88aa9f304e5cbf395c2e83644188
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Micaela Ziraldo, Juan E. Bidart, Cecilia A. Prato, María V. Tribulatti, Patricia Zamorano, Nora Mattion, Alejandra L. D’Antuono
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Although replication-defective human adenovirus type 5 (Ad5) vectors that express in situ the capsid-encoding region of foot-and-mouth disease virus (FMDV) have been proven to be effective as vaccines in relevant species for several viral strains, th
Externí odkaz:
https://doaj.org/article/3bc04fe637f748b1b8d60a121de42e2a