Zobrazeno 1 - 10
of 361
pro vyhledávání: '"repertoire diversity"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
We have previously argued that the antigen receptors of T and B lymphocytes evolved to be sufficiently specific to avoid massive deletion of clonotypes by negative selection. Their optimal ‘specificity’ level, i.e., probability of binding any par
Externí odkaz:
https://doaj.org/article/af6df0c92e9e4353bb4807749fa84229
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe diversity of the antigenic T cell receptor (TCR) repertoire clonally expressed on T lymphocytes is a key element of the adaptive immune system protective functions. A decline in diversity in the older adults is associated with health de
Externí odkaz:
https://doaj.org/article/16e5346e67924706a565964b02f5079c
Autor:
Markus Niebuhr, Farbod Bahreini, Anke Fähnrich, Christina Bomholt, Katja Bieber, Enno Schmidt, Saleh Ibrahim, Christoph M. Hammers, Kathrin Kalies
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmune diseases develop over years - starting from a subclinical phenotype to clinically manifest autoimmune disease. The factors that drive this transition are ill-defined. To predict the turning point towards clinical disease and to intervene i
Externí odkaz:
https://doaj.org/article/fb7fbde9e3184d9bba14938530d02777
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The specificity of T cells is that each T cell has only one T cell receptor (TCR). A T cell clone represents a collection of T cells with the same TCR sequence. Thus, the number of different T cell clones in an organism reflects the number of differe
Externí odkaz:
https://doaj.org/article/1c0e5efdeb4f400b971717fc9cb8f2c1
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2022)
Immune reconstitution (IR) after allogeneic haematopoietic cell transplantation (HCT) represents a central determinant of the clinical post-transplant course, since the majority of transplant-related outcome parameters such as graft-vs.-host disease
Externí odkaz:
https://doaj.org/article/6f5be99312f041f2bfd4c855a5c5abfd
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The capacity of T cells to recognize and mount an immune response against tumor antigens depends on the large diversity of the T-cell receptor (TCR) repertoire generated in the thymus during the process of T-cell development. However, this process is
Externí odkaz:
https://doaj.org/article/6c36bc8b1f474f11b82dd6e097a78eed
Autor:
Roberta Amoriello, Maria Chernigovskaya, Victor Greiff, Alberto Carnasciali, Luca Massacesi, Alessandro Barilaro, Anna M. Repice, Tiziana Biagioli, Alessandra Aldinucci, Paolo A. Muraro, David A. Laplaud, Andreas Lossius, Clara Ballerini
Publikováno v:
EBioMedicine, Vol 68, Iss , Pp 103429- (2021)
Background: T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the T-cell receptor (TCR) repertoir
Externí odkaz:
https://doaj.org/article/9548b214c40f43b3ae8bd667decfb8cd
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Autor:
F. Milano, R. O. Emerson, R. Salit, K. A. Guthrie, L. A. Thur, A. Dahlberg, H. S. Robins, C. Delaney
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
IntroductionCord blood transplantation (CBT) recipients are at increased risk of mortality due to delayed immune recovery (IR). Prior studies in CBT patients have shown that recovery of absolute lymphocyte count is predictive of survival after transp
Externí odkaz:
https://doaj.org/article/faf8699ca20d40fea182280a07b86ea1
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1
Externí odkaz:
https://doaj.org/article/f9a876b4982948c89307c338668342f1