Zobrazeno 1 - 10
of 238
pro vyhledávání: '"repair inhibition"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1132-1149 (2024)
Cancer, a complex and heterogeneous disease, arises from genomic instability. Currently, DNA damage-based cancer treatments, including radiotherapy and chemotherapy, are employed in clinical practice. However, the efficacy and safety of these therapi
Externí odkaz:
https://doaj.org/article/69c9132cb83c4e10bbf74daf80d9cceb
Autor:
Airong Li, Chenglin Liang, Lihua Xu, Yiyang Wang, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1329-1340 (2021)
5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and po
Externí odkaz:
https://doaj.org/article/b4fb5a95ef24457aac9e5be43da79c2c
Autor:
Jinjin Shi, Junjie Liu, Lihua Xu, Airong Li, Yiyang Wang, Chenglin Liang, Kaixiang Zhang, Wei Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1329-1340 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9b2a36b6514b777b857c1e9f8e4cbd
http://www.sciencedirect.com/science/article/pii/S2211383521000903
http://www.sciencedirect.com/science/article/pii/S2211383521000903
Akademický článek
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Publikováno v:
J Neurosci
Adult-onset neurodegenerative diseases are often accompanied by evidence of a chronic inflammation that includes activation of microglial cells and altered levels of brain cytokines. Aspects of this response are likely secondary reactions to neurodeg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3292dcc3b98642ac1df6509a50111e
https://doi.org/10.1523/jneurosci.0845-21.2021
https://doi.org/10.1523/jneurosci.0845-21.2021
Autor:
Sateja Paradkar, Adam Hendricson, Mark Plummer, Ranjini K. Sundaram, James Herrington, Denton Hoyer, Ranjit S. Bindra, Yulia V. Surovtseva, Piyasena Hewawasam
Publikováno v:
Oncotarget
Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system with a dismal prognosis. Locoregional failure is common despite high doses of radiation therapy, which has prompted great interest in developing novel strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b96f25b0746c867fcdee576b3c9434
https://doi.org/10.18632/oncotarget.27933
https://doi.org/10.18632/oncotarget.27933
Publikováno v:
Biochemical and Biophysical Research Communications. 550:56-61
CDK1 plays key roles in cell cycle progression through the G2/M phase transition and activation of homologous recombination (HR) DNA repair pathway. Accordingly, various CDK1 inhibitors have been developed for cancer therapy that induce prolonged G2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756eda09231c75ad0d090301dcc69bdd
https://doi.org/10.1016/j.bbrc.2021.02.117
https://doi.org/10.1016/j.bbrc.2021.02.117
Autor:
Michał Nowakowski, Michał Padjasek, Artur Krężel, Wiktor Koźmiński, Maciej Pyrka, Maciej Maciejczyk, Olga Kerber
Publikováno v:
Chemistry – A European Journal. 26:3297-3313
CdII is a major genotoxic agent that readily displaces ZnII in a multitude of zinc proteins, abrogates redox homeostasis, and deregulates cellular metalloproteome. To date, this displacement has been described mostly for cysteine(Cys)-rich intraprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78dc92eb5aea4d40395933b02f2d6195
https://doi.org/10.1002/chem.201904942
https://doi.org/10.1002/chem.201904942
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 6, Pp 910-920 (2019)
Background/aims Exposure to heavy metals is today a threat to society. The understanding of the molecular processes related to diseases related to exposure to metals mixture involve changes in the expression of microRNAs. Changes on microRNAs express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a28b3f80e7e0eac2600e4f43850f43b
https://www.cellphysiolbiochem.com/Articles/000181/
https://www.cellphysiolbiochem.com/Articles/000181/
Publikováno v:
International Journal of Cancer
Radiotherapy is one of the most used treatment approaches for head and neck squamous cell carcinoma (HNSCC). Targeted inhibition of DNA repair machinery has the potential to improve treatment response by tailoring treatment to cancer cells lacking sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acf712ee3a2a328649a7b834b3254bf
https://doi.org/10.1002/ijc.32558
https://doi.org/10.1002/ijc.32558