Výsledky vyhledávání

Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study

Autor: Mohamed K El-Ashrey, Yassin M. Nissan, Rana H. Refaey

Publikováno v: Virology

The COVID-19 pandemic has urged for the repurposing of existing drugs for rapid management and treatment. Renin inhibitors down regulation of ACE2, which is an essential receptor for SARS-CoV-2 infection that is responsible for COVID-19, in addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da26b36673c150daa4f1b017d37cd7e

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Akademický článek

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Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension

Publikováno v: European Journal of Clinical Investigation. 29(12):1019-1026

Background In essential hypertension an elevated renal vascular resistance (RVR) may be a marker of renin-angiotensin-aldosterone system-mediated impairment of renal sodium excretion. This hypothesis was tested by investigating whether, in subjects w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::112e4a68f41e7a7e7153935d44f0b11d
https://research.rug.nl/en/publications/489e7ed4-bab0-4b6c-b762-226cd70f8297

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Does the renin-angiotensin system determine the renal and systemic hemodynamic response to sodium in patients with essential hypertension?

Publikováno v: Hypertension. 27(2):202-208

Many patients with essential hypertension respond to a high dietary sodium intake with a rise in blood pressure. Experimental evidence suggests that the renal hemodynamic response to sodium determines, at least partially, this rise in blood pressure.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::fb20299c7cc728530963e8065bb0f9af
https://research.rug.nl/en/publications/6977cb71-0ecd-4c33-8fc9-a08d151a588b

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RENAL AND SYSTEMIC EFFECTS OF THE RENIN INHIBITOR REMIKIREN IN PATIENTS WITH ESSENTIAL-HYPERTENSION

Publikováno v: Journal of Cardiovascular Pharmacology. 26(1):39-45

Remikiren is an orally available renin inhibitor with an established blood pressure-lowering effect in patients with essential hypertension. No data are available on the renal effects of remikiren in humans. We therefore studied the effects of a sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::24e47df1f2cccde0b31ffa27c53e78cb
https://research.rug.nl/en/publications/c26a31c3-e6a7-409a-b5ec-3a0110747af5

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Dissertation/ Thesis

Asymmetric Hydrogenation of Functionalized Olefins Using N,P-Ligated Iridium Complexes

Autor: Zhou, Taigang

Transition-metal-catalyzed asymmetric hydrogenation is one of the most efficient, straightforward, and well-established methods for preparing enantiomerically enriched compounds. Over the past decades, significant progress has been made with iridium,

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182648