Zobrazeno 1 - 10
of 226
pro vyhledávání: '"regulatory variants"'
Autor:
Samin Farhangi, Marta Gòdia, Martijn F.L. Derks, Barbara Harlizius, Bert Dibbits, Rayner González-Prendes, Richard P.M.A. Crooijmans, Ole Madsen, Martien A.M. Groenen
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Integration of high throughput DNA genotyping and RNA-sequencing data enables the discovery of genomic regions that regulate gene expression, known as expression quantitative trait loci (eQTL). In pigs, efforts to date have been m
Externí odkaz:
https://doaj.org/article/af54900aec264479a2216afcf03789fc
Autor:
Alassane Thiam, Samia Nisar, Mathieu Adjemout, Frederic Gallardo, Oumar Ka, Babacar Mbengue, Gora Diop, Alioune Dieye, Sandrine Marquet, Pascal Rihet
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-7 (2023)
Abstract Background Genome-wide association studies have identified ATP2B4 as a severe malaria resistance gene. Recently, 8 potential causal regulatory variants have been shown to be associated with severe malaria. Methods Genotyping of rs10900585, r
Externí odkaz:
https://doaj.org/article/2d8ace7c7f324aad80161b9d776f20fc
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 150 (2024)
Despite collective efforts to understand the complex regulation of reproductive traits, no causative genes and/or mutations have been reported yet. By integrating genomics and transcriptomics data, potential regulatory mechanisms may be unveiled, pro
Externí odkaz:
https://doaj.org/article/197b036d1d6a47b6b9a28f663af680aa
Akademický článek
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Akademický článek
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Publikováno v:
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Congenital heart disease (CHD) is the leading cause of mortality from birth defects. In adult CHD patients with successful surgical repair, cardiac complications including heart failure develop at late stage, likely due to genetic
Externí odkaz:
https://doaj.org/article/7aba1433f87b42b2a2d66339a1c4d22a
Publikováno v:
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background Type 2 diabetes mellitus (T2D) is a common and complex disease. Dysfunction of pancreatic β cells, which cannot release sufficient insulin, plays a central role in T2D. Genetics plays a critical role in T2D etiology. Transcriptio
Externí odkaz:
https://doaj.org/article/cde0ea79abce419b92e5cda39d85153e
Autor:
Shengxue Liu, Cuiping Li, Hongwei Wang, Shuhui Wang, Shiping Yang, Xiaohu Liu, Jianbing Yan, Bailin Li, Mary Beatty, Gina Zastrow-Hayes, Shuhui Song, Feng Qin
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Gene expression is a key determinant of cellular response. Natural variation in gene expression bridges genetic variation to phenotypic alteration. Identification of the regulatory variants controlling the gene expression in respo
Externí odkaz:
https://doaj.org/article/3f57ff5a093d4f0ba2c7b1cad043f3ad
Autor:
Li Chen, Mulin Jun Li
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/9a6b884281554f2dabbe64b0a4b27243
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Despite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating
Externí odkaz:
https://doaj.org/article/bb5790f8891746f986ba64887aeec5e2