Regulatory acceptance and use of serology for inactivated veterinary rabies vaccines

Autor: Schiffelers, Marie-Jeanne W. A., Blaauboer, Bas J., Bakker, Wieger E., Hendriksen, Coenraad F. M., Public Management, LS IRAS Tox CMT/ATX, Dep Bestuurs- en Organisatiewetenschap, Public Governance, Sub 3V Centrum ULS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1, UU LEG Research USG Public Matters

Publikováno v: ALTEX-Alternatives to Animal Experimentation, 32(3), 211. Springer International Publishing AG

In April 2013 the mouse antibody serum neutralization test (SNT) was formally incorporated into European Pharmacopoeia monograph 0451 for potency testing of inactivated veterinary rabies vaccines. The SNT is designed to replace the highly variable an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750ac5605c75f524e81ab3f521fa02a8
https://pubmed.ncbi.nlm.nih.gov/26536289

Regulatory acceptance and use of the extended one generation reproductive toxicity study within Europe

Autor: Schiffelers, M.J.W.A., Blaauboer, B.J., Bakker, W.E., Hendriksen, C.F.M., Krul, C.

Publikováno v: Regulatory Toxicology and Pharmacology, 1, 71, 114-124

The two-generation study (OECD TG 416) is the standard requirement within REACH to test reproductive toxicity effects of chemicals with production volumes >100. tonnes. This test is criticized in terms of scientific relevance and animal welfare. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c6502db934e2437007ecf3cd422bc45d
http://resolver.tudelft.nl/uuid:6ff88b75-8d62-4c54-96d1-bc15ed0d1b96

Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: Expert opinions on the state of affairs and the way forward

Autor: Schiffelers, M.J.W.A., Blaauboer, B.J., Bakker, W.E., Beken, S., Hendriksen, C.F.M., Koeter, H., Krul, C.A.M.

Publikováno v: Regulatory Toxicology and Pharmacology, 1, 69, 41-48

Pharmaceuticals and chemicals are subjected to regulatory safety testing accounting for approximately 25% of laboratory animal use in Europe. This testing meets various objections and has led to the development of a range of 3R models to Replace, Red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7a2f9e5af30cef241315f12e9794ee94
http://resolver.tudelft.nl/uuid:08035945-ccae-4c61-8a0c-523ecad637c9

Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe.

Autor: Schiffelers MJ; Utrecht University School of Governance, Bijlhouwerstraat 6, 3511 ZC Utrecht, The Netherlands. Electronic address: m.j.w.a.schiffelers@uu.nl., Blaauboer BJ; Utrecht University, Institute for Risk Assessment Sciences (IRAS), P.O. Box 80.178, 3508 TD Utrecht, The Netherlands., Bakker WE; Utrecht University School of Governance, Bijlhouwerstraat 6, 3511 ZC Utrecht, The Netherlands., Hendriksen CF; Utrecht University, Faculty of Veterinary Medicine, Department Animals in Science and Society, P.O. Box 80.163, 3508 TD Utrecht, The Netherlands; Institute for Translational Vaccinology (Intravacc), P.O. Box 450, 3720 AL Bilthoven, The Netherlands., Krul C; TNO, P.O. Box 360, 3700 AJ Zeist, The Netherlands; University of Applied Sciences Utrecht, Life Sciences & Chemistry, F.C. Dondersstraat 65, 3572 JE Utrecht, The Netherlands.

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2015 Feb; Vol. 71 (1), pp. 114-24. Date of Electronic Publication: 2014 Oct 28.