Zobrazeno 1 - 10
of 379
pro vyhledávání: '"regulatory T cell (Treg)"'
Autor:
Qian Chen, Meiying Shen, Min Yan, Xiaojian Han, Song Mu, Ya Li, Luo Li, Yingming Wang, Shenglong Li, Tingting Li, Yingying Wang, Wang Wang, Zhengqiang Wei, Chao Hu, Aishun Jin
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression mediated by CCR8+ Tregs observed in breast and lung malignancies sugg
Externí odkaz:
https://doaj.org/article/5844da9c306e40a196f6d141ff44bb5f
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 7, Pp 830-838 (2024)
Tumor microenvironment (TME) is a complex cellular environment where tumor cells reside, along with various types of cells and extracellular components surrounding the tumor cells. Immune cells are key components of TME, including tumor-associated ma
Externí odkaz:
https://doaj.org/article/8b7c54b7f8e0499f8c03c4638141bdbf
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract The T-helper 17 (Th17) cell and regulatory T cell (Treg) axis plays a crucial role in the development of multiple sclerosis (MS), which is regarded as an immune imbalance between pro-inflammatory cytokines and the maintenance of immune toler
Externí odkaz:
https://doaj.org/article/3fd917ebe4e54ed78b1ebadeb6a55db9
Autor:
Disi Zhang, Dong Zhan, Rui Zhang, Yunyan Sun, Ci Duan, Jiapeng Yang, Jia Wei, Xianshi Li, Yanqi Lu, Xun Lai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Multiple myeloma (MM) progression involves diminished tumor antigen presentation and an immunosuppressive microenvironment, characterized by diminished expression of major histocompatibility complexes (MHC) class I molecule and elevated prog
Externí odkaz:
https://doaj.org/article/95ae17e8a1b2432485085590b7ac439b
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes (DUBs), a protein superfamily consisting of more than 100 members, deconjugate ubiquitin chai
Externí odkaz:
https://doaj.org/article/be832de6c2344d1585efd96155d54739
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/fa42aa8c83bf4af18869a4c18def31dc
Autor:
Shining Ma, Michelle So, Aazam Ghelani, Rohith Srivas, Anupama Sahoo, Robyn Hall, Wenjun Liu, Hao Wu, Sherman Yu, Shiping Lu, Elly Song, Taryn Cariaga, Marcus Soto, Hong Zhou, Chi-Ming Li, Ashutosh Chaudhry, Xin Luo, Sue J. Sohn
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-2 (IL-2), along with T-cell receptor (TCR) signaling, are required to control regulatory T cell (Treg) homeostasis and function in vivo. Due to the heightened sensitivity to IL-2, Tregs retain the ability to respond to low-dose or attenua
Externí odkaz:
https://doaj.org/article/4b2f7fa5bd9b408db48f01f99aa68ebe
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Laurène Pousse, Koorosh Korfi, Bruno C. Medeiros, Marco Berrera, Nadine Kumpesa, Jan Eckmann, Idil Karakoc Hutter, Vera Griesser, Vaios Karanikas, Christian Klein, Maria Amann
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundAcute Myeloid leukemia is a heterogeneous disease that requires novel targeted treatment options tailored to the patients’ specific microenvironment and blast phenotype.MethodsWe characterized bone marrow and/or blood samples of 37 AML pa
Externí odkaz:
https://doaj.org/article/26b1cfeae8be48eea4e271097d31fc49