Zobrazeno 1 - 10
of 85
pro vyhledávání: '"regulatory SNP"'
Autor:
Aksinya N. Uvarova, Elina A. Zheremyan, Alina S. Ustiugova, Matvey M. Murashko, Elvina A. Bogomolova, Denis E. Demin, Ekaterina M. Stasevich, Dmitry V. Kuprash, Kirill V. Korneev
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10196 (2024)
Interleukin 10 (IL10) is a major anti-inflammatory cytokine that acts as a master regulator of the immune response. A single nucleotide polymorphism rs3024505(C/T), located downstream of the IL10 gene, is associated with several aggressive inflammato
Externí odkaz:
https://doaj.org/article/3b3a1584c73c4986b9883004e53ef759
Akademický článek
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Autor:
Lihui Jin, Zhenyuan Han, Zhongli Jiang, Jieru Lu, Yizhuo Wu, Bingqian Yan, Weibin Zhang, Xuedong Lin, Lvyan Jiang, Pengjun Zhao, Kun Sun
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
VSD combined with other cardiac or extracardiac malformations (defined as “complex VSD” by us) is one of the major causes of perinatal morbidity and mortality. Functional non-coding SNPs (cis-regulatory SNPs) have not been systematically studied
Externí odkaz:
https://doaj.org/article/1eac06962840455da452e64d68ff5fbf
Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 3, Pp 1756-1777 (2021)
Genome-wide association studies (GWAS) have identified more than 2000 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility, most of which are located in the non-coding region. However, the causal SNPs functioning as gen
Externí odkaz:
https://doaj.org/article/8c5eb13940b94b18a4bd21c6425ff4e4
Akademický článek
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Autor:
Xin Qi, Yan Wen, Ping Li, Chujun Liang, Bolun Cheng, Mei Ma, Shiqiang Cheng, Lu Zhang, Li Liu, Om Prakash Kafle, Feng Zhang
Publikováno v:
International Journal of Bipolar Disorders, Vol 8, Iss 1, Pp 1-7 (2020)
Abstract Background Bipolar disorder (BD) is a complex mood disorder. The genetic mechanism of BD remains largely unknown. Methods We conducted an integrative analysis of genome-wide association study (GWAS) and regulatory SNP (rSNP) annotation datas
Externí odkaz:
https://doaj.org/article/d231881fd3754e7c8d4d5fc10c4238c9
Autor:
Oyuna S. Kozhevnikova, Anzhella Zh. Fursova, Anna S. Derbeneva, Ida F. Nikulich, Mikhail S. Tarasov, Vasiliy A. Devyatkin, Yulia V. Rumyantseva, Darya V. Telegina, Nataliya G. Kolosova
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1658 (2022)
Neovascular age-related macular degeneration (nAMD) is the leading cause of vision loss in the elderly. The gold standard of nAMD treatment is intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors. Genetic factors may influe
Externí odkaz:
https://doaj.org/article/4f0800209b1a4783a9db6b3470110dce
Publikováno v:
Biology, Vol 11, Iss 5, p 684 (2022)
Single nucleotide polymorphisms (SNPs) that are located in the promoter regions of genes and affect the binding of transcription factors (TFs) are called regulatory SNPs (rSNPs). Their identification can be highly valuable for the interpretation of g
Externí odkaz:
https://doaj.org/article/1be388ed79bc42658f1614b73e10e969
Akademický článek
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Autor:
Ubaid Ullah, Syed Bilal Ahmad Andrabi, Subhash Kumar Tripathi, Obaiah Dirasantha, Kartiek Kanduri, Sini Rautio, Catharina C. Gross, Sari Lehtimäki, Kanchan Bala, Johanna Tuomisto, Urvashi Bhatia, Deepankar Chakroborty, Laura L. Elo, Harri Lähdesmäki, Heinz Wiendl, Omid Rasool, Riitta Lahesmaa
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2094-2106 (2018)
Summary: Regulatory T (Treg) cells are critical in regulating the immune response. In vitro induced Treg (iTreg) cells have significant potential in clinical medicine. However, applying iTreg cells as therapeutics is complicated by the poor stability
Externí odkaz:
https://doaj.org/article/743de4152c564e59b634c5b49edf2b2c