Zobrazeno 1 - 10 of 632 pro vyhledávání: '"rectifier potassium current"'
1
Akademický článek
Injection of IK1 through dynamic clamp can make all the difference in patch-clamp studies on hiPSC-derived cardiomyocytes
Autor: Arie O. Verkerk, Ronald Wilders
Publikováno v: Frontiers in Physiology, Vol 14 (2023)
Human-induced stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool for studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC-CMs are depolarized and spontaneously active, even the working cardiomyocyte subt
Externí odkaz: https://doaj.org/article/feee9de844df42e697c94b9a90c74737
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2
Akademický článek
Investigating the Cocaine-induced Reduction of Potassium Current on the Generation of Action Potentials Using a Computational Model
Autor: Hadi Borjkhani, Mehdi Borjkhani, Morteza A. Sharif
Publikováno v: Basic and Clinical Neuroscience, Vol 13, Iss 1, Pp 15-24 (2022)
Introduction: Drugs of abuse, such as cocaine, affect different brain regions and lead to pathological memories. These abnormal memories may occur due to changes in synaptic transmissions or variations in synaptic properties of neurons. It has been s
Externí odkaz: https://doaj.org/article/454fbc4a2cf045959ca67e78b6d61705
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3
Akademický článek
Combination of Sildenafil and Ba2+ at a Low Concentration Show a Significant Synergistic Inhibition of Inward Rectifier Potassium Current Resulting in Action Potential Prolongation
Autor: Martin Macháček, Olga Švecová, Markéta Bébarová
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Sildenafil (Viagra) is a vasodilator mainly used in the treatment of erectile dysfunction. Atrial or ventricular fibrillation may rarely occur as a side effect during sildenafil therapy. Although changes in inward rectifier potassium currents includi
Externí odkaz: https://doaj.org/article/bb2d4d2babf14c94a80ed28ee439110f
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4
Akademický článek
Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons
Autor: Kun Cui, Shuai Zhang, Jinyao Sun, Xueying Zhang, Chong Ding, Guizhi Xu
Publikováno v: BMC Neuroscience, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background Transcranial ultrasonic stimulation is a novel noninvasive tool for neuromodulation, and has high spatial resolution and deep penetration. Although it can increase excitation of neurons, its effects on neuron are poorly understood
Externí odkaz: https://doaj.org/article/e279dd0f7c4b4290b251096b82c2a559
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5
Akademický článek
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6
Akademický článek
Inhibition of inward rectifier potassium currents by chloroquine causes significant electrophysiological changes in the rat thoracic veins myocardium
Autor: A.D. Ivanova, V.S. Kuzmin
Publikováno v: Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki, Vol 160, Iss 4, Pp 645-653 (2018)
Thoracic (caval and pulmonary) vein myocardial tissue is considered as a source of ectopic activity capable of initiating atrial fibrillation. The reasons which underline thoracic vein proarrhythmicity may be related to the expression level of the in
Externí odkaz: https://doaj.org/article/f121b8bd0f674678819a166d78e34151
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8
Human Sinoatrial Node Pacemaker Activity
Autor: Arie O. Verkerk, Ronald Wilders
Publikováno v: International journal of molecular sciences, 24(8):7264. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7264
The pacemaker activity of the sinoatrial node (SAN) has been studied extensively in animal species but is virtually unexplored in humans. Here we assess the role of the slowly activating component of the delayed rectifier K+ current (IKs) in human SA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7da4fd658da12ea93112f9976e6a8d2
http://www.scopus.com/inward/record.url?scp=85156232708&partnerID=8YFLogxK
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9
Akademický článek
Effects of Secretome from Fat Tissues on Ion Currents of Cardiomyocyte Modulated by Sodium-Glucose Transporter 2 Inhibitor
Autor: Shih-Jie Jhuo, I-Hsin Liu, Wei-Chung Tsai, Te-Wu Chou, Yi-Hsiung Lin, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai
Publikováno v: Molecules, Vol 25, Iss 16, p 3606 (2020)
Sodium-glucose transporter 2 (SGLT2) inhibitors were shown to decrease mortality from cardiovascular diseases in the EMPA-REG trial. However, the effects of empagliflozin (EMPA) for cardiac arrhythmia are not yet clarified. A total of 20 C57BL/6J mic
Externí odkaz: https://doaj.org/article/e4c575f07bf547678224fe5f3aca8afa
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10
A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5
Autor: Szilvia Déri, Teodóra Hartai, László Virág, Norbert Jost, Alain J. Labro, András Varró, István Baczkó, Stanley Nattel, Balázs Ördög
Publikováno v: Pharmaceuticals; Volume 15; Issue 12; Pages: 1550
PHARMACEUTICALS
Long QT syndrome (LQTS) is an inherited cardiac rhythm disorder associated with increased incidence of cardiac arrhythmias and sudden death. LQTS type 5 (LQT5) is caused by dominant mutant variants of KCNE1, a regulatory subunit of the voltage-gated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d493cae7bfba362352f6a0f5390c783e
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Plný text Recenzováno Digitální knihovna AV ČR
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