Zobrazeno 1 - 10
of 479
pro vyhledávání: '"receptor selectivity"'
Autor:
Kayleigh Walker, Roberta Baravalle, Rachel Holyfield, Jacqueline Kalms, Helena Wright, Chitra Seewooruthun, Frederick W. Muskett, Anthony Scott-Tucker, Andy Merritt, Alistair Henry, Alastair D. G. Lawson, Gareth Hall, Christine Prosser, Mark D. Carr
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases. IL-13 signals through a ternary signalling complex f
Externí odkaz:
https://doaj.org/article/ed60b6efb669458b96fb34943581aadf
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 9, Iss , Pp 100212- (2023)
Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor
Externí odkaz:
https://doaj.org/article/6bb39d7d90864ed6bf7da28ea879c603
Autor:
Claudia Mugnaini, Magdalena Kostrzewa, Marta Casini, Poulami Kumar, Valeria Catallo, Marco Allarà, Laura Guastaferro, Antonella Brizzi, Marco Paolino, Andrea Tafi, Christelos Kapatais, Gianluca Giorgi, Federica Vacondio, Marco Mor, Federico Corelli, Alessia Ligresti
Publikováno v:
Molecules, Vol 28, Iss 13, p 4958 (2023)
Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide derivatives were shown to act at the CB2
Externí odkaz:
https://doaj.org/article/1a82bb1f8bab4fb8bc8f13d08c4c3492
Autor:
Janine Suthiram, Ané Pieters, Zulfiah Mohamed Moosa, Jan Rijn Zeevaart, Mike M. Sathekge, Thomas Ebenhan, Ross C. Anderson, Claire L. Newton
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2134 (2023)
Radiopharmaceutical development hinges on the affinity and selectivity of the biological component for the intended target. An analogue of the neuropeptide Substance P (SP), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-[Thi8,Met(O2)11]-SP
Externí odkaz:
https://doaj.org/article/c2f02b93f82d44cd93f835ef7a5bdecf
Autor:
Jessica Lu, Sarah J. Piper, Peishen Zhao, Laurence J. Miller, Denise Wootten, Patrick M. Sexton
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8069 (2022)
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide (VIP) are neuropeptides involved in a diverse array of physiological and pathological processes through activating the PACAP subfamily of class B1 G protein-coup
Externí odkaz:
https://doaj.org/article/edb972d629da4d60926c157cb0755b83
Autor:
Ligresti, Claudia Mugnaini, Magdalena Kostrzewa, Marta Casini, Poulami Kumar, Valeria Catallo, Marco Allarà, Laura Guastaferro, Antonella Brizzi, Marco Paolino, Andrea Tafi, Christelos Kapatais, Gianluca Giorgi, Federica Vacondio, Marco Mor, Federico Corelli, Alessia
Publikováno v:
Molecules; Volume 28; Issue 13; Pages: 4958
Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide derivatives were shown to act at the CB2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::c1e38441112e878ff826ebc81c27a5ec
Akademický článek
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Autor:
Lena Tveriakhina, Karin Schuster-Gossler, Sanchez M Jarrett, Marie B Andrawes, Meike Rohrbach, Stephen C Blacklow, Achim Gossler
Publikováno v:
eLife, Vol 7 (2018)
DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 a
Externí odkaz:
https://doaj.org/article/3e44a1b2e4f44a3eb3307bd5a10ef345
Autor:
Richard Lim, Danny J. Eckert, Luigi Taranto-Montemurro, Jayne C. Carberry, Scott A. Sands, A Aishah, Andrew Wellman
Publikováno v:
J Appl Physiol (1985)
The combination of the noradrenergic agent atomoxetine plus the antimuscarinic oxybutynin has recently been shown to improve upper airway physiology and reduce obstructive sleep apnea (OSA) severity. However, the effects of different antimuscarinics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5be46cd4942cea83ef0c7f8c91c9eb3
https://doi.org/10.1152/japplphysiol.01074.2020
https://doi.org/10.1152/japplphysiol.01074.2020
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.