Zobrazeno 1 - 10
of 500
pro vyhledávání: '"receptor modulation"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 875 (2024)
The unintended modulation of nuclear receptor (NR) activity by drugs can lead to toxicities amongst the endocrine, gastrointestinal, hepatic cardiovascular, and central nervous systems. While secondary pharmacology screening assays include NRs, safet
Externí odkaz:
https://doaj.org/article/a1d6f1b2234d4e938197f844f1ec0caa
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionSex differences in the adaptation to pressure overload have been described in humans, as well as animal models, and have been related to sex-specific expression of mitochondrial genes. We therefore tested whether sex differences in cardia
Externí odkaz:
https://doaj.org/article/07c83e0503ad4b1299e86098092db838
Akademický článek
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Autor:
Jessica Marie Gajda, MS, Marina Asiedu, PhD, Gladys Morrison, PhD, Jacqueline Ann Dunning, Nayereh Ghoreishi-Haack, MS, Amanda Lynn Barth, PhD
Publikováno v:
Medicine in Drug Discovery, Vol 9, Iss , Pp 100067- (2021)
Pain is both a sensory and emotional experience, which serves an adaptive purpose by protecting the body from prolonged and repeated tissue damage. However, the presence of chronic pain can transition to a maladaptive state leading to life-long suffe
Externí odkaz:
https://doaj.org/article/cba687b5a95a4db5937adae4b551528d
Autor:
Lenin David Ochoa-de la Paz, Martin González-Andrade, Herminia Pasantes-Morales, Rodrigo Franco, Rubén Zamora-Alvarado, Edgar Zenteno, Hugo Quiroz-Mercado, Roberto Gonzales-Salinas, Rosario Gulias-Cañizo
Publikováno v:
BMC Neuroscience, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitter receptors. This study aimed to determine if the dual action of taurine on GABAC-ρ1R relates to its structure. To address this, we tested th
Externí odkaz:
https://doaj.org/article/1feb3e14e7f24ad7ba81cfdfa30e5208
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1997 Mar 01. 94(5), 2041-2044.
Externí odkaz:
https://www.jstor.org/stable/41582
Publikováno v:
Frontiers in Psychology, Vol 10 (2019)
Depression is a serious psychiatric disorder with an enormous socioeconomic burden, and it is commonly comorbid with pain, chronic fatigue, or other inflammatory diseases. Recent studies have shown that acupuncture is an effective therapeutic method
Externí odkaz:
https://doaj.org/article/d449ab6b25364d42837bab389c853e3e
Autor:
Sana A. Shaikh, Drew M. Dolino, Garam Lee, Sudeshna Chatterjee, David M. MacLean, Charlotte Flatebo, Christy F. Landes, Vasanthi Jayaraman
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 328-335 (2016)
Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and ga
Externí odkaz:
https://doaj.org/article/0f2e191d51224f0bb2ef0484742717d7
Autor:
Simon-Guth, Szabolcs
Gammaaminosmörsyrareceptorer typ A (GABAAR) är pentameriska ligandstyrda kloridkanaler som uppvisar neurohämmande egenskaper. Därmed är de primära läkemedelsmål för flera ångestdämpande och lugnande läkemedel som används för att minska
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-334213
Akademický článek
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