Zobrazeno 1 - 2
of 2
pro vyhledávání: '"rat-specific toxicant"'
Autor:
Fernanda Ricchelli, Alessandra Zulian, Brian Hopkins, David Rennison, Margaret A. Brimble, Sergio Bova, Maurizio Cavalli
Publikováno v:
Bioorganic & medicinal chemistry
15 (2007): 2963–2974. doi:10.1016/j.bmc.2007.02.012
info:cnr-pdr/source/autori:Rennison D; Bova S; Cavalli M; Ricchelli F; Zulian A; Hopkins B; Brimble MA/titolo:Synthesis and activity studies of analogues of the rat selective toxicant norbormide/doi:10.1016%2Fj.bmc.2007.02.012/rivista:Bioorganic & medicinal chemistry (Print)/anno:2007/pagina_da:2963/pagina_a:2974/intervallo_pagine:2963–2974/volume:15
15 (2007): 2963–2974. doi:10.1016/j.bmc.2007.02.012
info:cnr-pdr/source/autori:Rennison D; Bova S; Cavalli M; Ricchelli F; Zulian A; Hopkins B; Brimble MA/titolo:Synthesis and activity studies of analogues of the rat selective toxicant norbormide/doi:10.1016%2Fj.bmc.2007.02.012/rivista:Bioorganic & medicinal chemistry (Print)/anno:2007/pagina_da:2963/pagina_a:2974/intervallo_pagine:2963–2974/volume:15
Norbormide [5-(alpha-hydroxy-alpha-2-pyridylbenzyl)-7-(alpha-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB, 1), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents
Autor:
Alessandra Zulian, Gabriella Cargnelli, Margaret A. Brimble, Federica Dabbeni-Sala, Olivia Laita, Valeria Petronilli, David Rennison, Sergio Bova, Dong Jun Lee, Maurizio Cavalli, Fernanda Ricchelli, Paolo Bernardi, Jessica Stäb, Brian Hopkins
Publikováno v:
Biochimica et biophysica acta. Bioenergetics 1767 (2007): 980–988. doi:10.1016/j.bbabio.2007.04.002
info:cnr-pdr/source/autori:Zulian A; Petronilli V; Bova S; Dabbeni-Sala F; Cargnelli G; Cavalli M; Rennison D; Stäb J; Laita O; Lee DJ; Brimble MA; Hopkins B; Bernardi P; Ricchelli F/titolo:Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide/doi:10.1016%2Fj.bbabio.2007.04.002/rivista:Biochimica et biophysica acta. Bioenergetics/anno:2007/pagina_da:980/pagina_a:988/intervallo_pagine:980–988/volume:1767
info:cnr-pdr/source/autori:Zulian A; Petronilli V; Bova S; Dabbeni-Sala F; Cargnelli G; Cavalli M; Rennison D; Stäb J; Laita O; Lee DJ; Brimble MA; Hopkins B; Bernardi P; Ricchelli F/titolo:Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide/doi:10.1016%2Fj.bbabio.2007.04.002/rivista:Biochimica et biophysica acta. Bioenergetics/anno:2007/pagina_da:980/pagina_a:988/intervallo_pagine:980–988/volume:1767
It was recently demonstrated that the rat-selective toxicant norbormide also induces rat-selective opening of the permeability transition pore (PTP) in isolated mitochondria. Norbormide is a mixture of endo and exo stereoisomers; however, only the en