Zobrazeno 1 - 10
of 59 145
pro vyhledávání: '"rat-liver"'
Autor:
Su-Min Bak, Seng-Min Back, Da Yeon Kim, Soyoung Jung, Na-Young Jeung, Nan-Young Kim, Kang-Hyun Han, Yong-Bum Kim, Byoung-Seok Lee, Jun Hong Park, Hee Jun Cho, Hee Gu Lee, Ozkan Ozden, Sang Kyum Kim, Seong-Hoon Park
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with
Externí odkaz:
https://doaj.org/article/85b4f4bb8d8141bdab1372c82fdfd13a
Publikováno v:
Toxicology Reports, Vol 12, Iss , Pp 215-223 (2024)
N-nitrosamines, a very heterogeneous class of chemicals, may enter humans in small amounts through various sources and are produced endogenously, too. Some are known to be mutagenic carcinogens and have recently been detected as impurities in several
Externí odkaz:
https://doaj.org/article/3d8d8dc76b9b44bb8f2aedc345bface7
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/faaeb75c32da47f8bec709beb10543f9
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35070- (2024)
Introduction: The presence of phytochemicals in herbal medicines can lead to herb-drug interactions, altering the levels of these compounds and conventional drugs in the bloodstream by influencing CYP450 activity. Considering curcumin's effect on the
Externí odkaz:
https://doaj.org/article/ab489fb71b4b460ab024b28cd9b374dd
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1257 (2024)
Objectives: Pharmacokinetic issues were the leading cause of drug attrition, accounting for approximately 40% of all cases before the turn of the century. To this end, several high-throughput in vitro assays like microsomal stability have been develo
Externí odkaz:
https://doaj.org/article/584a938732b645b5adf4af3147c4f2f2
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-8 (2023)
Abstract Background Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic enzymes activate multip
Externí odkaz:
https://doaj.org/article/b5e3715d87a846bc99e3c5ba6095b4c1
Autor:
SUN Nana, ZHANG Qiannan, LIANG Chunlai, ZHI Yuan, LIU Haibo, FANG Jin, LI Yongning, JIA Xudong
Publikováno v:
Zhongguo shipin weisheng zazhi, Vol 35, Iss 9, Pp 1258-1264 (2023)
ObjectiveApplying the in vivo Mammalian Alkaline Comet Test， this study aimed to investigate the DNA damage caused by the food additive titanium dioxide and nano-titanium dioxide on rat liver cells.MethodsAccording to the guideline “In vivo mamma
Externí odkaz:
https://doaj.org/article/6feaf6c2acc54af7992ad31e17219bce
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1053 (2024)
Kokusaginine is a bioactive ingredient extracted from Ruta graveolens L., which has a range of biological activities. Its pharmacokinetic (PK) properties are particularly important for clinical applications; however, they have not been fully elucidat
Externí odkaz:
https://doaj.org/article/cbf9a69f33f8470d9e73f8f3bc9a01e5