Výsledky vyhledávání - "ras GTPase-Activating Proteins/chemistry"

Revisiting G3BP1 as a RasGAP Binding Protein: Sensitization of Tumor Cells to Chemotherapy by the RasGAP 317–326 Sequence Does Not Involve G3BP1

Autor: Jamal Tazi, Sophie G. Martin, Christian Widmann, Aline Dousse, Alessandro Annibaldi

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e29024 (2011)
PLoS One, vol. 6, no. 12, pp. e29024
PloS one
PLoS ONE
PLoS ONE, Public Library of Science, 2011, 6 (12), pp.e29024. ⟨10.1371/journal.pone.0029024⟩

International audience; RasGAP is a multifunctional protein that controls Ras activity and that is found in chromosomal passenger complexes. It also negatively or positively regulates apoptosis depending on the extent of its cleavage by caspase-3. Ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c302a4cb5c2bd55d65f613bd29c589a2
https://doi.org/10.1371/journal.pone.0029024

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RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes

Autor: Hadi Khalil, Nieves Peltzer, Christian Widmann, Jiang-Yan Yang, Evrim Jaccard, Natasa Bulat, Gilles Dubuis

Publikováno v: PLOS ONE
PLoS One, vol. 6, no. 7, pp. e22609
PLoS ONE
PLoS ONE, Vol 6, Iss 7, p e22609 (2011)

The caspase-3-generated RasGAP N-terminal fragment (fragment N) inhibits apoptosis in a Ras-PI3K-Akt-dependent manner. Fragment N protects various cell types, including insulin-secreting cells, against different types of stresses. Whether fragment N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9f33fe6ea49832e6150dc446835681
http://journals.plos.org/plosone/article/asset?id=10.1371/journal.pone.0022609.PDF

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