Zobrazeno 1 - 10
of 154
pro vyhledávání: '"rapastinel"'
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 1, Pp 128-135 (2020)
Accumulating evidence indicates that inhalation anesthetics induce or increase the risk of cognitive impairment. GLYX-13 (rapastinel) acts on the glycine site of N-methyl-D-aspartate receptors (NMDARs) and has been shown to enhance hippocampus-depend
Externí odkaz:
https://doaj.org/article/7b817c4b19ce45f08d78ad50ded035c9
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol Volume 13, Pp 973-980 (2017)
Andrei-Nicolae Vasilescu,1,* Nina Schweinfurth,2,* Stefan Borgwardt,2,* Peter Gass,1 Undine E Lang,2,* Dragos Inta,1,2,* Sarah Eckart2,* 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidel
Externí odkaz:
https://doaj.org/article/1a720397f9c44e768d8c24e2c20a934c
Autor:
Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E Lang, Dragos Inta, Peter Gass
Publikováno v:
International Journal of Neuropsychopharmacology. 25:946-950
Summary Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f59ffdaff55a79c3a82f81a3809172c
https://doi.org/10.1093/ijnp/pyac051
https://doi.org/10.1093/ijnp/pyac051
Autor:
Babita Bisht, Nandita Madhavan
Publikováno v:
The Journal of Organic Chemistry. 86:17667-17672
Peptide drugs bradykinin, a leuprolide analogue, 2(PZ-128), and rapastinel are synthesized in 56-77% yield using heating-assisted liquid-phase peptide synthesis on a soluble polynorbornene support. These drugs of commercial utility and complex struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66636cc54251cb9ad16213c5d547b9a
https://doi.org/10.1021/acs.joc.1c01906
https://doi.org/10.1021/acs.joc.1c01906
Autor:
Thomas Hochadel, Antonia Periclou, J. Christopher Stein, Jonathan Rojo, Shengfang Su, Gary G. Kay, Ramesh Boinpally
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 255-266 (2022)
Clinical and Translational Science
Clinical and Translational Science
N‐methyl‐D‐aspartate ionotropic glutamatergic receptor (NMDAR) modulators, including rapastinel and ketamine, elicit rapid and sustained antidepressant responses in patients with treatment‐resistant major depressive disorder. This phase I, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574d95f5c8dbc91edf4122d12234cc53
https://doi.org/10.1111/cts.13145
https://doi.org/10.1111/cts.13145
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 1, Pp 128-135 (2020)
Neural Regeneration Research
Neural Regeneration Research
Accumulating evidence indicates that inhalation anesthetics induce or increase the risk of cognitive impairment. GLYX-13 (rapastinel) acts on the glycine site of N-methyl-D-aspartate receptors (NMDARs) and has been shown to enhance hippocampus-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38695305ca854d0bcc422a8f458fc2d7
http://www.nrronline.org/article.asp?issn=1673-5374
http://www.nrronline.org/article.asp?issn=1673-5374
Publikováno v:
Brain Research Bulletin. 163:170-177
Despite the growing burden of major depressive disorder (MDD) on the society, therapeutic management that is mostly based on the conventional monoaminergic mechanisms, is significantly delimited especially from low response rate and time lag for trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663a00c5d3f15221f75f7cc9817415ad
https://doi.org/10.1016/j.brainresbull.2020.07.022
https://doi.org/10.1016/j.brainresbull.2020.07.022
Autor:
Peter Gass, Natascha Pfeiffer, Dragos Inta, Undine E. Lang, Andrei-Nicolae Vasilescu, Anne S. Mallien
Publikováno v:
European Archives of Psychiatry and Clinical Neuroscience. 271:1587-1591
Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ae4c20d0d12e8828dcee90430f4345
https://doi.org/10.1007/s00406-020-01180-5
https://doi.org/10.1007/s00406-020-01180-5
Autor:
Golam M. I. Chowdhury, Gerard Sanacora, Danielle M. Gerhard, Ronald S. Duman, Taro Kato, Rong-Jian Liu, Alexa-Nicole Sliby, Kevin L. Behar, Pradeep Banerjee, Ryota Shinohara, Santosh Pothula, Min Wu
Publikováno v:
Molecular Psychiatry. 26:5097-5111
Both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can exert rapid antidepressant effects as shown in several animal and human studies. However, how this bidirectional modulation of NMDARs causes similar antidepressan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e03e141cf0ebcc1b40db308e27626af8
https://doi.org/10.1038/s41380-020-0796-3
https://doi.org/10.1038/s41380-020-0796-3
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