Zobrazeno 1 - 10
of 66
pro vyhledávání: '"randomised placebo-controlled trial"'
Autor:
Alexander Gerhard, Richard Sharples, Tsepo Goerttler, Kathryn McDonald, Eszter Visi, Rainer Hinz, Federico Turkheimer, Isabel Lewzey, Karl Herholz, Andreas H. Jacobs, Clive Holmes
Publikováno v:
Exploration of Neuroscience, Vol 2, Iss 2, Pp 52-66 (2023)
Aim: Microglial activation is increasingly recognised as a factor in the progression of Alzheimer’s disease (AD) and may be modified by systemic inflammatory signals including serum tumour necrosis factor (TNF)-α. The aim was to investigate whethe
Externí odkaz:
https://doaj.org/article/8e7485364cb346a99bb854966d873498
Akademický článek
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Autor:
Na Nie, Le Chen, Tong Li, Chuanlong Zhou, Bangwei Li, Conghua Ji, Jie Zhou, Qin Chen, Qiushuang Li, Yi Liang, Jianqiao Fang
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Headache attacks severely impaired life quality and increase the economic burden of migraineurs. Electroacupuncture (EA) has been used worldwidely to treat several pain-related diseases including migraines. However, whether EA wit
Externí odkaz:
https://doaj.org/article/4e2cbb2a615e49bdae55a53a76a57ca4
Autor:
Murat Akova, Serhat Unal
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-3 (2021)
Abstract Objectives The primary objective is to evaluate the efficacy of an inactivated and aluminium hydroxide adsorbed SARS-CoV-2 vaccine (Sinovac, China) in voluntary participants after 14 days of the second dose against RT-PCR confirmed symptomat
Externí odkaz:
https://doaj.org/article/80eb43f18e874af58c41a4e9e6cd99b1
Autor:
Julie K. Wright, Darrell H. S. Tan, Sharon L. Walmsley, Jennifer Hulme, Erin O’Connor, Carolyn Snider, Ivy Cheng, Adrienne K. Chan, Bjug Borgundvaag, Shelley McLeod, Michael H. Gollob, Rosemarie J. Clarke, Linda Dresser, Fatima Haji, Tony Mazzulli, Samira Mubareka, Peter Jüni, Dominic Lee, George Tomlinson, Kevin C. Kain, Megan Landes
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Abstract Objectives Primary Objective: To determine if pre-exposure prophylaxis (PrEP) with 400mg hydroxychloroquine (HCQ), taken orally once daily reduces microbiologically confirmed COVID-19 among front line health care workers at high risk for SAR
Externí odkaz:
https://doaj.org/article/23c235c5f1014753bd2386bd25150636
Autor:
Anouk Pels, Janus C. Jakobsen, Wessel Ganzevoort, Christiana A. Naaktgeboren, Wes Onland, Aleid G. van Wassenaer-Leemhuis, Christian Gluud
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Objective The objective of the Dutch Sildenafil therapy in dismal prognosis early onset fetal growth restriction (STRIDER) randomised clinical trial is to assess the beneficial and harmful effects of sildenafil versus placebo on fetal and ne
Externí odkaz:
https://doaj.org/article/dc1f7a5a0d544385bb5c00f7e6457256
Autor:
A. Pels, L. C. Kenny, Z. Alfirevic, P. N. Baker, Peter von Dadelszen, C. Gluud, C. T. Kariya, B. W. Mol, A. T. Papageorghiou, A. G. van Wassenaer-Leemhuis, W. Ganzevoort, K. M. Groom, the international STRIDER Consortium
Publikováno v:
BMC Pregnancy and Childbirth, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formatio
Externí odkaz:
https://doaj.org/article/d58485fbd48c41659c90b30b8d7480b8
Autor:
Anthony C Gordon, Shalini Santhakumaran, Farah Al-Beidh, Robert ML Orme, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Alexina J Mason, Josie K Ward, Kieran P O’Dea, Timothy Felton, Mary Cross, Janis Best-Lane, Jonas Lexow, Ashley Campbell, Deborah Ashby
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 5, Iss 6 (2018)
Background: In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects. Levosimendan (Simdax®; Orion Pharma, Newbury, UK) is a calcium-sensitising
Externí odkaz:
https://doaj.org/article/0fdb3781dce7473aa22a1e9ace439a37
Autor:
Arri Coomarasamy, Helen Williams, Ewa Truchanowicz, Paul T Seed, Rachel Small, Siobhan Quenby, Pratima Gupta, Feroza Dawood, Yvonne E Koot, Ruth Bender Atik, Kitty WM Bloemenkamp, Rebecca Brady, Annette Briley, Rebecca Cavallaro, Ying C Cheong, Justin Chu, Abey Eapen, Holly Essex, Ayman Ewies, Annemieke Hoek, Eugenie M Kaaijk, Carolien A Koks, Tin-Chiu Li, Marjory MacLean, Ben W Mol, Judith Moore, Steve Parrott, Jackie A Ross, Lisa Sharpe, Jane Stewart, Dominic Trépel, Nirmala Vaithilingam, Roy G Farquharson, Mark David Kilby, Yacoub Khalaf, Mariëtte Goddijn, Lesley Regan, Rajendra Rai
Publikováno v:
Health Technology Assessment, Vol 20, Iss 41 (2016)
Background and objectives: Progesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians and Gynaecologists and a Cochrane review called for a definitive trial to test whether or not progesterone therapy
Externí odkaz:
https://doaj.org/article/c2c17247e8b7424c8d0a4e985677c1a1
Autor:
Chinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, Jonathan Grigg
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 2, Iss 6 (2015)
Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALO
Externí odkaz:
https://doaj.org/article/e389b15af83d434d9203485d3db93a46