Zobrazeno 1 - 10
of 560
pro vyhledávání: '"random walk with restart"'
Publikováno v:
Synthetic and Systems Biotechnology, Vol 10, Iss 1, Pp 148-155 (2025)
Drug combination therapy, involving the use of two or more drugs, has been widely employed to treat complex diseases such as cancer. It enhances therapeutic efficacy, reduces drug resistance, and minimizes side effects. However, traditional methods t
Externí odkaz:
https://doaj.org/article/1f074eba696c4b17b063fe51c1776631
Autor:
Francis E. Agamah, Thomas H. A. Ederveen, Michelle Skelton, Darren P. Martin, Emile R. Chimusa, Peter A. C. ’t Hoen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
BackgroundCOVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). Each disease phase is marked by changes in omics profiles with corresponding changes in the expression of features (biosignatures). However, int
Externí odkaz:
https://doaj.org/article/da6917fc083f4b01b143c354996d6281
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Biological networks have proven invaluable ability for representing biological knowledge. Multilayer networks, which gather different types of nodes and edges in multiplex, heterogeneous and bipartite networks, provide a natural w
Externí odkaz:
https://doaj.org/article/9f1e34c21ed543a08beaa9d321659347
Publikováno v:
SoftwareX, Vol 26, Iss , Pp 101701- (2024)
Environmental factors are external conditions that can affect the health of living organisms. For a number of rare genetic diseases, an interplay between genetic and environmental factors is known or suspected. However, the studies are limited by the
Externí odkaz:
https://doaj.org/article/ef1592731ecb4a76873c40929c1cb9a5
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background circRNAs play an important role in drug resistance and cancer development. Recently, many studies have shown that the expressions of circRNAs in human cells can affect the sensitivity of cells to therapeutic drugs, thus significan
Externí odkaz:
https://doaj.org/article/7a31eadf98fa44d3abac2cebcce67f3e
Publikováno v:
Bioengineering, Vol 11, Iss 7, p 680 (2024)
Accumulating scientific evidence highlights the pivotal role of miRNA–disease association research in elucidating disease pathogenesis and developing innovative diagnostics. Consequently, accurately identifying disease-associated miRNAs has emerged
Externí odkaz:
https://doaj.org/article/bc6afdda97794b38be425d9fb8229f3b
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: MicroRNAs (miRNAs) are a class of non-coding RNA molecules that play a crucial role in the regulation of diverse biological processes across various organisms. Despite not encoding proteins, miRNAs have been found to have significant im
Externí odkaz:
https://doaj.org/article/617a60b44d52416baffaec0d0b7fea04
Publikováno v:
Clinical, Cosmetic and Investigational Dermatology, Vol Volume 16, Pp 651-658 (2023)
Tianyi Wang,1,* Wang You,2,* Linna Zhao,3 Bingxin Zhang,1 Hongmei Wang4 1Department of Dermatology, First Teaching Hospital of Tianjin University of TCM, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tian
Externí odkaz:
https://doaj.org/article/c16ba708680146059c2b7a1b3cd79f1c
Publikováno v:
Journal of King Saud University: Computer and Information Sciences, Vol 34, Iss 10, Pp 9409-9418 (2022)
Collaborator recommendation helps scholars find suitable collaborators, which is useful for the development of scientific research and the transformation of scientific and technological achievements. However, the gap between scholars’ academic leve
Externí odkaz:
https://doaj.org/article/abb48d0124334e858a11c762579c8a06
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Identification of disease-associated long non-coding RNAs (lncRNAs) is crucial for unveiling the underlying genetic mechanisms of complex diseases. Multiple types of similarity networks of lncRNAs (or diseases) can complementary and comprehensively c
Externí odkaz:
https://doaj.org/article/fcbddb5bbecc496190ce331b47414180