Zobrazeno 1 - 10
of 138
pro vyhledávání: '"ralbp1"'
Autor:
Awasthi, Sanjay, Tompkins, Joshua, Singhal, Jyotsana, Riggs, Arthur D., Yadav, Sushma, Wu, Xiwei, Singh, Sharda, Warden, Charles, Liu, Zheng, Wang, Jinhui, Slavin, Thomas P., Weitzel, Jeffrey N., Yuan, Yate-Ching, Awasthi, Meenakshi, Srivastava, Satish K., Awasthi, Yogesh C., Singhal, Sharad S.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Apr 01. 115(15), 3918-3923.
Externí odkaz:
https://www.jstor.org/stable/26508485
Autor:
Ashly Hindle, Chhanda Bose, Jihyun Lee, Philip T. Palade, Christopher J. Peterson, P. Hemachandra Reddy, Sanjay Awasthi, Sharda P. Singh
Publikováno v:
Cancers, Vol 14, Iss 527, p 527 (2022)
Cancers; Volume 14; Issue 3; Pages: 527
Cancers; Volume 14; Issue 3; Pages: 527
Rlip76 (Rlip) is a multifunctional membrane protein that facilitates the high metabolic rates of cancer cells through the efflux of toxic metabolites and other functions. Rlip inhibition or depletion results in broad-spectrum anti-cancer effects in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4bf672182c3d23d432a8315757ae81
https://pubmed.ncbi.nlm.nih.gov/35158795
https://pubmed.ncbi.nlm.nih.gov/35158795
Autor:
Sanjay Awasthi, J. Josh Lawrence, Neha Sawant, Lloyd E Bunquin, Ashley Hindle, Sudhir Kshirsagar, Hafiz M. R. Khan, Sharda P. Singh, Chhanda Bose, Mathew George, Philip Palade, Hallie Morton, Murali Vijayan, P. Hemachandra Reddy
The purpose of our study is to understand the role of the Ralbp1 gene in oxidative stress (OS), mitochondrial dysfunction and cognition in Alzheimer’s disease (AD) pathogenesis. The Ralbp1 gene encodes the 76 kDa protein Rlip (aka RLIP76). Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42b30ccaa5eb8086166baa566715d7d
https://doi.org/10.1101/2021.09.20.461132
https://doi.org/10.1101/2021.09.20.461132
Autor:
Rakhshanda Layeequr Rahman, Jihyun Lee, Sharad S. Singhal, Sharda P. Singh, Hongzhi Li, Philip Palade, Chhanda Bose, Jonathan Kopel, Catherine Jones, Sanjay Awasthi, Yate-Ching Yuan, Ashly Hindle
Publikováno v:
Cancers, Vol 13, Iss 3329, p 3329 (2021)
Cancers
Volume 13
Issue 13
Cancers
Volume 13
Issue 13
Simple Summary Rlip knockout has been reported to prevent cancer in highly cancer-susceptible mice lacking p53, and Rlip knockdown kills many types of cancer cells. In humans, breast cancer shows diverse characteristics, including HER2-driven subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f228e073825644317a6fc060c3fa3b
https://www.mdpi.com/2072-6694/13/13/3329
https://www.mdpi.com/2072-6694/13/13/3329
Autor:
Sharad S. Singhal, David Berz, Chhanda Bose, Catherine Jones, Jihyun Lee, Philip Palade, Sanjay Awasthi, Sushma Yadav, Rakhshanda Layeequr Rahman, Shabnam Rehman, Ashly Hindle, Jyotsana Singhal, Naga K. S. Cheedella, Meenakshi Darden, Sharda P. Singh
Publikováno v:
Cancers
Volume 12
Issue 6
Cancers, Vol 12, Iss 1446, p 1446 (2020)
Volume 12
Issue 6
Cancers, Vol 12, Iss 1446, p 1446 (2020)
RLIP76 (RAL-binding protein-1, Rlip) is a stress-protective mercapturic-acid-pathway transporter protein that also plays a key role in regulating clathrin-dependent endocytosis as a Ral effector. Targeted inhibition or depletion of Rlip causes regres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb27662a1f68c22577886b919e9d6129
https://pubmed.ncbi.nlm.nih.gov/32498332
https://pubmed.ncbi.nlm.nih.gov/32498332
Autor:
Henry Palangdao Igid, Lokesh Dalasanur Nagaprashantha, William C. Green, Vijay S. Tonk, David Berz, Lukman Tijani, Yogesh C. Awasthi, Aditya Rajan, Zheng Liu, Sharad S. Singhal, Yate-Ching Yuan, Hongzhi Li, Jyotsana Singhal, Sharda P. Singh, Sanjay Awasthi
Publikováno v:
Oncotarget
Scopus-Elsevier
Scopus-Elsevier
In previous studies, we found that 2'-hydroxyflavonone (2HF), a citrus flavonoid, inhibits the growth of renal cell carcinoma in a VHL-dependent manner. This was associated with the inhibition of glutathione S-transferases (GSTs), the first step enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c2151dac0468ff730a1b75e88ea132
http://europepmc.org/articles/PMC6281421
http://europepmc.org/articles/PMC6281421
Autor:
Zheng Liu, Sharad S. Singhal, Jinhui Wang, Sanjay Awasthi, Sushma Yadav, Thomas P. Slavin, Xiwei Wu, Arthur D. Riggs, Meenakshi Awasthi, Jyotsana Singhal, Joshua D. Tompkins, Charles Warden, Yogesh C. Awasthi, Sharda P. Singh, Jeffrey N. Weitzel, Yate-Ching Yuan, Satish K. Srivastava
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mice that have homozygous deletion of the p53 tumor suppressor protein universally die of malignancy, generally before 6 months of age. We show that hemizygous deficiency of RALBP1 (RLIP76 or Rlip) confers a degree of protection from spo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3726fee39194f5d3b3af1b334bcde6d2
https://doi.org/10.1073/pnas.1719586115
https://doi.org/10.1073/pnas.1719586115
Autor:
Hallie Morton, Chhanda Bose, Hafiz M. R. Khan, Sudhir Kshirsagar, Lloyd E Bunquin, P. Hemachandra Reddy, J. Josh Lawrence, Neha Sawant, Sharda P. Singh, Sanjay Awasthi, Murali Vijayan, Mathew George, Philip Palade, Ashly Hindle
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 3113, p 3113 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3113, p 3113 (2021)
The purpose of our study is to understand the role of the RALBP1 gene in oxidative stress (OS), mitochondrial dysfunction and cognition in Alzheimer’s disease (AD) pathogenesis. The RALPB1 gene encodes the 76 kDa protein RLIP76 (Rlip). Rlip functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83860ed6d47a7c716460479207a4b4b8
https://doi.org/10.3390/cells10113113
https://doi.org/10.3390/cells10113113
Autor:
Aditya Rajan, Sharda P. Singh, William C. Green, Sharad S. Singhal, Michelle Tarbox, Henry Palangdao Igid, Philip Palade, Somedeb Ball, Vijay S. Tonk, Chhanda Bose, Jihyun Lee, Sanjay Awasthi, Ashly Hindle
Publikováno v:
Cancers, Vol 11, Iss 10, p 1556 (2019)
Cancers
Volume 11
Issue 10
Cancers
Volume 11
Issue 10
2&prime
hydroxyflavanone (2HF) is a dietary flavonoid with anticancer activity towardsmultiple cancers. Here, we report that topically applied 2HF inhibits the growth of intradermalimplants of melanoma in immunocompetent mice. 2HF induced apopto
hydroxyflavanone (2HF) is a dietary flavonoid with anticancer activity towardsmultiple cancers. Here, we report that topically applied 2HF inhibits the growth of intradermalimplants of melanoma in immunocompetent mice. 2HF induced apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a46fdddbf1629b882ceef7bc37048d
https://www.mdpi.com/2072-6694/11/10/1556
https://www.mdpi.com/2072-6694/11/10/1556
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