Zobrazeno 1 - 10
of 3 765
pro vyhledávání: '"radioligand binding"'
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-6 (2023)
Abstract Objective To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given. In our search for novel adenosine receptor ligands, our resear
Externí odkaz:
https://doaj.org/article/ce0adf95f77e4ce99f2d4a5ada522cf0
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 23-30 (2022)
Effect of Pantogam active subchronic administration (200 mg/kg/day, i.p.) on the behavior of outbred CD-1 mice in the experimental model of attention deficit disorder was studied in the "closed enriched cross maze" test. Pantogam active corrected the
Externí odkaz:
https://doaj.org/article/9feb8249b1df4ea985fe39d2ebae4d74
Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Ozanimod, a sphingosine 1-phosphate (S1P) receptor modulator, binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5), and is approved in multiple countries for treating adults with relapsing forms of multiple sclerosis (M
Externí odkaz:
https://doaj.org/article/9dc57cec861d4797a9e0381574cf9039
Autor:
Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya, Sultan T. Abu-Orabi, Robert J. Doerksen, Stephen J. Cutler
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 1, Pp 103545- (2022)
The cannabinoid receptor 2 (CB2 receptor) has attracted considerable interest, mainly due to its potential as a target for therapeutics for treating various diseases that have a neuroinflammatory or neurodegenerative component while avoiding the adve
Externí odkaz:
https://doaj.org/article/e155f8c981fa43f99cbbbced5bbfc653
Akademický článek
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Publikováno v:
Molecules, Vol 27, Iss 11, p 3529 (2022)
Background: Membrane cholesterol dysregulation has been shown to alter the activity of the adenosine A2A receptor (A2AR), a G protein-coupled receptor, thereby implicating cholesterol levels in diseases such as Alzheimer’s and Parkinson’s. A limi
Externí odkaz:
https://doaj.org/article/4c4d8a50fc1e44b298841334f32e576b
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Humulus lupulus L. (hops) is a major constituent of beer. It exhibits neuroactive properties that make it useful as a sleeping aid. These effects are hypothesized to be mediated by an increase in GABAA receptor function. In the quest to uncover the c
Externí odkaz:
https://doaj.org/article/a495b8aaada248cc8d42e605d7e61132
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
GABAA receptors are pentameric GABA-gated chloride channels. The existence of 19 different subunits (six α, three β, three γ, δ, ε, θ, π, and three ρ) in mammalian systems gives rise to an enormous theoretical diversity of GABAA receptor subt
Externí odkaz:
https://doaj.org/article/f4a17d425d514d119e8d59a445c19640
Autor:
Yusuke Sugasawa, Wayland WL Cheng, John R Bracamontes, Zi-Wei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C Senneff, Kathiresan Krishnan, David E Reichert, Douglas F Covey, Gustav Akk, Alex S Evers
Publikováno v:
eLife, Vol 9 (2020)
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but n
Externí odkaz:
https://doaj.org/article/28aa0ecba7e8446f9f22fbe67ffe09fd