Serum magnesium and calcium levels in relation to ischemic stroke Mendelian randomization study

Autor: Susanna C. Larsson, Matthew Traylor, Stephen Burgess, Giorgio B. Boncoraglio, Christina Jern, Karl Michaëlsson, Hugh S. Markus, Rainer Malik, Ganesh Chauhan, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, raci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei-Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang-Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez-Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin-Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei-Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O'Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil-Smoller, James G Wilson, Kerri L Wiggins, Qiong Yang, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu-Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean-François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez-Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller-Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba-Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti-Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano-Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres-Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Daniel Strbian, Israel Fernandez-Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

Publikováno v: Neurology
Neurology, American Academy of Neurology, 2019, 92 (9), pp.e944-e950. ⟨10.1212/WNL.0000000000007001⟩
Neurology 92, e944-e950 (2019)
Larsson, S C, Traylor, M, Burgess, S, Boncoraglio, G B, Jern, C, Michaëlsson, K, Markus, H S, Malik, R, Chauhan, G, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, A-K, van der Laan, S W, Gretarsdottir, S, Anderson, C D, Chong, M, Adams, H H H, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, R M, Benavente, O R, Bevan, S, Brown, R D, Butterworth, A S, Carrera, C, Carty, C L, Chasman, D I, Chen, W-M, Cole, J W, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, de Bakker, P I W, Destefano, A L, Hoed, M D, Duan, Q, Engelter, S T, Falcone, G J, Gottesman, R F, Grewal, R P, Gudnason, V, Gustafsson, S, Haessler, J, Harris, T B, Hassan, A, Havulinna, A S, Heckbert, S R, Holliday, E G, Howard, G, Hsu, F-C, Hyacinth, H I, Ikram, M A, Ingelsson, E, Irvin, M R, Jian, X, Jiménez-Conde, J, Johnson, J A, Jukema, J W, Kanai, M, Keene, K L, Kissela, B M, Kleindorfer, D O, Kooperberg, C, Kubo, M, Lange, L A, Langefeld, C D, Langenberg, C, Launer, L J, Lee, J-M, Lemmens, R, Leys, D, Lewis, C M, Lin, W-Y, Lindgren, A G, Lorentzen, E, Magnusson, P K, Maguire, J, Manichaikul, A, McArdle, P F, Meschia, J F, Mitchell, B D, Mosley, T H, Nalls, M A, Ninomiya, T, O'Donnell, M J, Psaty, B M, Pulit, S L, Rannikmäe, K, Reiner, A P, Rexrode, K M, Rice, K, Rich, S S, Ridker, P M, Rost, N S, Rothwell, P M, Rotter, J I, Rundek, T, Sacco, R L, Sakaue, S, Sale, M M, Salomaa, V, Sapkota, B R, Schmidt, R, Schmidt, C O, Schminke, U, Sharma, P, Slowik, A, Sudlow, C L M, Tanislav, C, Tatlisumak, T, Taylor, K D, Thijs, V N S, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, van Duijn, C M, Walters, M, Wareham, N J, Wassertheil-Smoller, S, Wilson, J G, Wiggins, K L, Yang, Q, Yusuf, S, Amin, N, Aparicio, H S, Arnett, D K, Attia, J, Beiser, A S, Berr, C, Buring, J E, Bustamante, M, Caso, V, Cheng, Y-C, Choi, S H, Chowhan, A, Cullell, N, Dartigues, J-F, Delavaran, H, Delgado, P, Dörr, M, Engström, G, Ford, I, Gurpreet, W S, Hamsten, A, Heitsch, L, Hozawa, A, Ibanez, L, Ilinca, A, Ingelsson, M, Iwasaki, M, Jackson, R D, Jood, K, Jousilahti, P, Kaffashian, S, Kalra, L, Kamouchi, M, Kitazono, T, Kjartansson, O, Kloss, M, Koudstaal, P J, Krupinski, J, Labovitz, D L, Laurie, C C, Levi, C R, Li, L, Lind, L, Lindgren, C M, Lioutas, V, Liu, Y M, Lopez, O L, Makoto, H, Martinez-Majander, N, Matsuda, K, Minegishi, N, Montaner, J, Morris, A P, Muiño, E, Müller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, E A, Peddareddygari, L R, Pedersen, N L, Pera, J, Perola, M, Pezzini, A, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribasés, M, Romero, J R, Roquer, J, Rudd, A G, Sarin, A-P, Sarju, R, Sarnowski, C, Sasaki, M, Satizabal, C L, Satoh, M, Sattar, N, Sawada, N, Sibolt, G, Sigurdsson, Á, Smith, A, Sobue, K, Soriano-Tárraga, C, Stanne, T, Stine, O C, Stott, D J, Strauch, K, Takai, T, Tanaka, H, Tanno, K, Teumer, A, Tomppo, L, Torres-Aguila, N P, Touze, E, Tsugane, S, Uitterlinden, A G, Valdimarsson, E M, van der Lee, S J, Völzke, H, Wakai, K, Weir, D, Williams, S R, Wolfe, C D A, Wong, Q, Xu, H, Yamaji, T, Sanghera, D K, Melander, O, Strbian, D, Fernandez-Cadenas, I, Longstreth, W T, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, J C, Saleheen, D, Stefansson, K, Worrall, B B, Kittner, S J, Seshadri, S, Fornage, M, Howson, J M M, Kamatani, Y, Debette, S & Dichgans, M 2019, ' Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study ', Neurology, vol. 92, no. 9, pp. E944-E950 . https://doi.org/10.1212/WNL.0000000000007001
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Universidad de Barcelona
Neurology, 92(9), E944-E950. Lippincott Williams and Wilkins

Comment inThe yin and yang of magnesium and calcium: New genetic insights for stroke? [Neurology. 2019]; International audience; Objective To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or

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https://doi.org/10.1212/WNL.0000000000007001