Zobrazeno 1 - 10
of 10
pro vyhledávání: '"rac1 GTP-Binding Protein/metabolism"'
Autor:
Deben, Debbie S, Creemers, Rob H, van Adrichem, Arjan J, Drent, Roosmarie, Merry, Audrey H H, Leers, Mathie P G, van Bodegraven, Adriaan A, Wong, Dennis R
Publikováno v:
Deben, D S, Creemers, R H, van Adrichem, A J, Drent, R, Merry, A H H, Leers, M P G, van Bodegraven, A A & Wong, D R 2022, ' A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients ', Scientific Reports, vol. 12, no. 1, 15806 . https://doi.org/10.1038/s41598-022-20197-5
Scientific Reports, 12(1):15806. Nature Publishing Group
Scientific Reports, 12(1):15806. Nature Publishing Group
The thiopurine derivatives azathioprine (AZA), mercaptopurine (MP) and tioguanine (TG) remain standard treatment of inflammatory bowel disease (IBD). The immune suppressive effect of thiopurines is primarily based on blocking the Ras-related C3 botul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbc2f106cd927332072a5f143dea7d9
https://doi.org/10.1038/s41598-022-20197-5
https://doi.org/10.1038/s41598-022-20197-5
Autor:
Woroniuk, Anna, Porter, Andrew, White, Gavin, Newman, Daniel T., Diamantopoulou, Zoi, Waring, Thomas, Rooney, Claire, Strathdee, Douglas, Marston, Daniel J., Hahn, Klaus M., Sansom, Owen J., Zech, Tobias, Malliri, Angeliki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Woroniuk, A, Porter, A, White, G, Newman, D, Diamantopoulou, Z, Waring, T, Rooney, C, Strathdee, D, Marston, D J, Hahn, K M, Sansom, O J, Zech, T & Malliri, A 2018, ' STEF/TIAM2 mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap ', Nature Communications, vol. 9, no. 1, 2124 . https://doi.org/10.1038/s41467-018-04404-4
Nature Communications
Woroniuk, A, Porter, A, White, G, Newman, D, Diamantopoulou, Z, Waring, T, Rooney, C, Strathdee, D, Marston, D J, Hahn, K M, Sansom, O J, Zech, T & Malliri, A 2018, ' STEF/TIAM2 mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap ', Nature Communications, vol. 9, no. 1, 2124 . https://doi.org/10.1038/s41467-018-04404-4
The perinuclear actin cap is an important cytoskeletal structure that regulates nuclear morphology and re-orientation during front-rear polarisation. The mechanisms regulating the actin cap are currently poorly understood. Here, we demonstrate that S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1a9c042b2f09eb5875604f0bda003db
https://doaj.org/article/8a03de08b5bf41b383217440b51867d5
https://doaj.org/article/8a03de08b5bf41b383217440b51867d5
Publikováno v:
Pathogens and Disease
Pathogens and Disease, Oxford University Press, 2018, 76 (5), ⟨10.1093/femspd/fty045⟩
Pathogens and Disease, 2018, 76 (5), ⟨10.1093/femspd/fty045⟩
Pathogens and Disease, Oxford University Press, 2018, 76 (5), ⟨10.1093/femspd/fty045⟩
Pathogens and Disease, 2018, 76 (5), ⟨10.1093/femspd/fty045⟩
Alterations of the cellular proteome over time due to spontaneous or toxin-mediated enzymatic deamidation of glutamine (Gln) and asparagine (Asn) residues contribute to bacterial infection and might represent a source of aging-related diseases. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc2a300bcc0ce0f316d60a44d103a72
https://hal.archives-ouvertes.fr/hal-02365647
https://hal.archives-ouvertes.fr/hal-02365647
Autor:
Julien Barbier, Jean-Christophe Cintrat, Emmanuel Lemichez, Daniel Gillet, Sylvain Pichard, Clémence Brewee, Orane Visvikis, Nassim Mahtal
Publikováno v:
ChemMedChem
ChemMedChem, 2018, 13 (7), pp.754-761. ⟨10.1002/cmdc.201700631⟩
ChemMedChem, Wiley-VCH Verlag, 2018, 13 (7), pp.754-761. ⟨10.1002/cmdc.201700631⟩
ChemMedChem, 2018, 13 (7), pp.754-761. ⟨10.1002/cmdc.201700631⟩
ChemMedChem, Wiley-VCH Verlag, 2018, 13 (7), pp.754-761. ⟨10.1002/cmdc.201700631⟩
International audience; Cytotoxic necrotizing factor 1 (CNF1) is a toxin produced by pathogenic strains of Escherichia coli responsible for extra‐intestinal infections. CNF1 deamidates Rac1, thereby triggering its permanent activation and worsening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a52037f00306a6a20796d5385cab4c
https://hal-pasteur.archives-ouvertes.fr/pasteur-02448858
https://hal-pasteur.archives-ouvertes.fr/pasteur-02448858
Autor:
Emilie Andrio, Emmanuel Lemichez, Jacqueline Cherfils, Poul H. Sorensen, Anne Doye, Daniel Hamaoui, Mads Daugaard, Raymond Ruimy, Frédéric Bost, Amel Mettouchi, Romain Lotte
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.44779. ⟨10.1038/srep44779⟩
Scientific Reports, 2017, 7 (1), pp.44779. ⟨10.1038/srep44779⟩
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.44779. ⟨10.1038/srep44779⟩
Scientific Reports, 2017, 7 (1), pp.44779. ⟨10.1038/srep44779⟩
The E3 ubiquitin ligase HACE1 is a potent tumor suppressor that controls cell proliferation and ubiquitylates the small GTPase Rac1 to target it to proteasomal degradation. Whether and how the activity of HACE1 is regulated by the N-terminal ankyrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369d0aeadf452cafe8e400b065e715d7
https://doi.org/10.1038/srep44779
https://doi.org/10.1038/srep44779
Autor:
Dominique Muller, Emmanuel Thévenot, Véronique Rousseau, Bernadette Boda, Jean-Vianney Barnier, Patricia Kreis
Publikováno v:
Journal of Biological Chemistry, Vol. 282, No 29 (2007) pp. 21497-21506
The p21-activated kinase 3 (PAK3) is one of the recently identified genes for which mutations lead to nonsyndromic mental retardation. PAK3 is implicated in dendritic spine morphogenesis and is a key regulator of synaptic functions. However, the unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3661c681716036ec9b8a068da4795c40
https://doi.org/10.1074/jbc.m703298200
https://doi.org/10.1074/jbc.m703298200
Autor:
Frédéric Larbret, Muriel Golzio, Olivier Cuvillier, Bernard Malavaud, Kathiane Laurent, Emmanuel Lemichez, Frédéric Bost, Fabienne Massa, Isabelle Ader, Amel Mettouchi, Mireille Cormont, Jean-François Tanti, Béatrice Dirat
Publikováno v:
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2015, 14 (2), pp.586-596. ⟨10.1158/1535-7163.MCT-14-0102⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2015, 14 (2), pp.586-596. ⟨10.1158/1535-7163.MCT-14-0102⟩
Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug metformin has been shown to display antitumoral properties in prostate cancer cell and animal model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeafddfe885bf10b6a816b5d30dd486b
https://hal-pasteur.archives-ouvertes.fr/pasteur-02448789
https://hal-pasteur.archives-ouvertes.fr/pasteur-02448789
Autor:
Barbara C. Snoek, Peter L. Hordijk, André M. Deelder, Eloise C. Anthony, Thomas Stumpel, Patricia C. Salinas, Madelon M. Maurice, Dirk Geerts, Paul J. Hensbergen, Bart-Jan de Kreuk, Daniele V.F. Tauriello, Micha Nethe
Publikováno v:
Journal of Cell Science, 125(14), 3430-3442
Journal of cell science, 125(Pt 14), 3430-3442. Company of Biologists Ltd
Nethe, M, de Kreuk, B-J, Tauriello, D V F, Anthony, E C, Snoek, B, Stumpel, T, Salinas, P C, Maurice, M M, Geerts, D, Deelder, A M, Hensbergen, P J & Hordijk, P L 2012, ' Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts ', Journal of Cell Science, vol. 125, no. 14, pp. 3430-3442 . https://doi.org/10.1242/jcs.100925
Journal of Cell Science, 125(14), 3430-3442. Company of Biologists Ltd
Journal of Cell Science
Journal of Cell Science, 125(Pt 14), 3430-42. Company of Biologists Ltd
Journal of cell science, 125(Pt 14), 3430-3442. Company of Biologists Ltd
Nethe, M, de Kreuk, B-J, Tauriello, D V F, Anthony, E C, Snoek, B, Stumpel, T, Salinas, P C, Maurice, M M, Geerts, D, Deelder, A M, Hensbergen, P J & Hordijk, P L 2012, ' Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts ', Journal of Cell Science, vol. 125, no. 14, pp. 3430-3442 . https://doi.org/10.1242/jcs.100925
Journal of Cell Science, 125(14), 3430-3442. Company of Biologists Ltd
Journal of Cell Science
Journal of Cell Science, 125(Pt 14), 3430-42. Company of Biologists Ltd
The Rho-GTPase Rac1 promotes actin polymerization and membrane protrusion that mediate initial contact and subsequent maturation of cell-cell junctions. Here we report that Rac1 associates to the ubiquitin-protein ligase neural precursor cell express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c93e1662353b42ccea12550ed60f435
http://hdl.handle.net/1887/97785
http://hdl.handle.net/1887/97785
Publikováno v:
Scandinavian Journal of Immunology
Scandinavian Journal of Immunology, Wiley, 2004, 59 (6), pp.527--35. ⟨10.1111/j.1365-3083.2004.01429.x⟩
Europe PubMed Central
Scandinavian Journal of Immunology, Wiley, 2004, 59 (6), pp.527--35. ⟨10.1111/j.1365-3083.2004.01429.x⟩
Europe PubMed Central
Vav1, the 95-kDa protein encoded by the vav1 proto-oncogene, is expressed exclusively in haematopoietic cells, where it becomes phosphorylated on tyrosine residues in response to antigen receptor ligation. Vav1 was found to act as a Rac1-specific gua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba9b68e827073ab11f651b5f0fd994d
https://hal.archives-ouvertes.fr/hal-02262378
https://hal.archives-ouvertes.fr/hal-02262378
Publikováno v:
Traffic, Vol. 1, No 5 (2000) pp. 399-410
Traffic (Copenhagen, Denmark)
Traffic (Copenhagen, Denmark)
Members of the myosin superfamily play crucial roles in cellular processes including management of the cortical cytoskeleton, organelle transport and signal transduction. GTPases of the Rho family act as key control elements in the reorganization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd98c896b5a266ff08de05707ae9fa87
https://archive-ouverte.unige.ch/unige:18919
https://archive-ouverte.unige.ch/unige:18919