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Derivation of snake venom gland organoids for in vitro venom production

Autor: Nicholas R. Casewell, Mátyás A. Bittenbinder, Hans Clevers, Harald M. I. Kerkkamp, Jens Puschhof, Yorick Post, Freek J. Vonk, Joep Beumer, Michael K. Richardson

Publikováno v: Nature Protocols, 16(3), 1494-1510. Nature Publishing Group
Puschhof, J, Post, Y, Beumer, J, Kerkkamp, H M, Bittenbinder, M, Vonk, F J, Casewell, N R, Richardson, M K & Clevers, H 2021, ' Derivation of snake venom gland organoids for in vitro venom production ', Nature Protocols, vol. 16, no. 3, pp. 1494-1510 . https://doi.org/10.1038/s41596-020-00463-4

More than 400,000 people each year suffer adverse effects following bites from venomous snakes. However, snake venom is also a rich source of bioactive molecules with known or potential therapeutic applications. Manually ‘milking’ snakes is the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd30f8baead05384455572a94b2aa20
http://www.scopus.com/inward/record.url?scp=85099969454&partnerID=8YFLogxK

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Linear plasmids in Klebsiella and other Enterobacteriaceae

Autor: Jane Hawkey, Hugh Cottingham, Alex Tokolyi, Ryan R. Wick, Louise M. Judd, Louise Cerdeira, Doroti de Oliveira Garcia, Kelly L. Wyres, Kathryn E. Holt

Publikováno v: Microbial Genomics. 8

Linear plasmids are extrachromosomal DNA elements that have been found in a small number of bacterial species. To date, the only linear plasmids described in the family Enterobacteriaceae belong to Salmonella , first found in Salmonella enterica Typh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793c1fd0babaae9f800f563677955e78
https://doi.org/10.1099/mgen.0.000807

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Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

Autor: Al Solaiss, Jaffer, Evans, Chloe, Oluoch, George O., Casewell, Nicholas, Harrison, Robert

Snake envenoming causes rapid systemic and local effects that often result in fatal or long-term disability outcomes. It seems likely that acute phase and inflammatory responses contribute to these haemorrhagic, coagulopathic, neurotoxic, nephrotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::345241dd9b329aebf728d906b5165d81
https://archive.lstmed.ac.uk/20161/1/toxins-14-00229.pdf

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Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria

Autor: Abdulsalami Nasidi, David G. Lalloo, Anna Trelfa, Robert A. Harrison, Stefanie Menzies, Rohit N. Patel, Aniekan O. Thomas, Nandul Durfa, Abdulrazaq G. Habib, Saidu B. Abubakar, Frank-Leonel Tianyi

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009518 (2021)
PLOS NEGLECTED TROPICAL DISEASES

Background Adverse reactions to antivenom considerably complicate the clinical management of snakebite envenomed patients because it necessitates a temporary suspension of life-saving antivenom, increases costs and can compromise patient outcomes. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fb1a2cc3fedd532ba07b6ae7b77516
http://europepmc.org/articles/PMC8384187

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Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms

Autor: Jaffer Alsolaiss, Nicholas R. Casewell, Edouard Crittenden, Nessrin Alomran, Stuart Ainsworth, Laura-Oana Albulescu, Robert A. Harrison

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009659 (2021)
PLoS Neglected Tropical Diseases

Background Snakebite is a neglected tropical disease that causes high global rates of mortality and morbidity. Although snakebite can cause a variety of pathologies in victims, haemotoxic effects are particularly common and are typically characterise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667c6e98cbb9374a7907833948e20cd6
https://doaj.org/article/7ac00559f88147a1afdb2e22c80d597c

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The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Autor: Rachel H. Clare, Teresa Escalante, Alexandra Rucavado, Tarek Mohamed Abd El-Aziz, Laura-Oana Albulescu, José María Gutiérrez, Nicholas R. Casewell

Publikováno v: Toxins
Toxins, Vol 13, Iss 451, p 451 (2021)

A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments. The mainstay in the therapy of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd461dfd399fe224e170608ed08dbaa3
https://archive.lstmed.ac.uk/18679/3/toxins-13-00451-v2.pdf

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Small molecule drug discovery for neglected tropical snakebite

Autor: Clare, Rachel, Hall, Steven, Patel, Rohit, Casewell, Nicholas

Snakebite envenoming is responsible for as many as 138,000 deaths annually, making it the world’s most lethal neglected tropical disease (NTD). There is an urgent need to improve snakebite treatment, which currently relies on outdated and poorly to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::faa51dd3da1fd6b32a683382f4c59120

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Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib

Autor: Freek J. Vonk, Arif Arrahman, Nicholas R. Casewell, Jeroen Kool, Mark C. Wilkinson, Kristina B.M. Still, Govert W. Somsen, Taline D. Kazandjian

Publikováno v: Toxins, 13(5):302, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Toxins, Vol 13, Iss 302, p 302 (2021)
Toxins
Volume 13
Issue 5
Kazandjian, T D, Arrahman, A, Still, K B M, Somsen, G W, Vonk, F J, Casewell, N R, Wilkinson, M C & Kool, J 2021, ' Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib ', Toxins, vol. 13, no. 5, 302, pp. 1-20 . https://doi.org/10.3390/toxins13050302

Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites. However, recent evidence suggests that some ela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780fc7d1ebd5ac06f310ba446cf3be32
https://research.vu.nl/en/publications/d1b5b65c-2a5f-46bd-a7d9-845dd5919a21

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