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Serum levels of anti-PspA and anti-PspC IgG decrease with age and do not correlate with susceptibility to experimental human pneumococcal colonization

Autor: Elissavet Nikolaou, Hugh Adler, Adriano P. Araujo, Maria Leonor S. Oliveira, Gabriela B. C. Colichio, Daniela M. Ferreira, Eliane N. Miyaji, Tao Chen, Esther L. German

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247056 (2021)

Older adults are at increased risk of pneumococcal disease. This work aims to evaluate whether there is any decrease in serum IgG against variants of the antigens Pneumococcal surface protein A (PspA) and Pneumococcal surface protein C (PspC) in heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16db4b70d0a1f19de7b9ad4616e76b9f
http://europepmc.org/articles/PMC7880446

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New ethical considerations in vaccine trials

Autor: Malcolm E. Molyneux

Publikováno v: Human Vaccines & Immunotherapeutics. 13:2160-2163

Known and novel pathogens continue to afflict the world's population, and we deploy existing and new vaccines - the best type of weapon we've got - against them. One consequence is that we are accumulating steadily more experience of both the scienti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384b212cba81effc019a73cd08490138
https://doi.org/10.1080/21645515.2016.1272744

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Causes of variability in latent phenotypes of childhood wheeze

Autor: Oksel, Ceyda, Granell, Raquel, Mahmoud, Osama, Custovic, Adnan, Henderson, A John

Publikováno v: Oksel, C, Granell, R, Mahmoud, O, Custovic, A, Henderson, J 2019, ' Causes of variability in latent phenotypes of childhood wheeze ', Journal of Allergy and Clinical Immunology, vol. 143, no. 5, pp. 1783-1790.e11 . https://doi.org/10.1016/j.jaci.2018.10.059
1790.e11

Background Latent class analysis (LCA) has been used extensively to identify (latent) phenotypes of childhood wheezing. However, the number and trajectory of discovered phenotypes differed substantially between studies. Objective We sought to investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cf5f16e7c58a58c02ac2317d366b576e
http://www.scopus.com/inward/record.url?scp=85059193374&partnerID=8YFLogxK

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Loss of Humoral and Cellular Immunity to Invasive Nontyphoidal Salmonella during Current or Convalescent Plasmodium falciparum Infection in Malawian Children

Autor: Queen Dube, Tonney S. Nyirenda, James T. Nyirenda, Kondwani C. Jambo, Robert S. Heyderman, Chisomo L. Msefula, Henry C. Mwandumba, Wilson L. Mandala, Melita A. Gordon, Janet Storm, Dumizulu L. Tembo

Publikováno v: CLINICAL AND VACCINE IMMUNOLOGY
Clinical and Vaccine Immunology : CVI

Invasive nontyphoidal Salmonella (iNTS) infections are commonly associated with Plasmodium falciparum infections, but the immunologic basis for this linkage is poorly understood. We hypothesized that P. falciparum infection compromises the humoral an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d0d9a88954110198c5112faf0cd5e7

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Glycan-independent binding and internalization of human IgG to FCMR, its cognate cellular receptory

Autor: Lloyd, Katy, Wang, Jiabin, Urban, Britta, Czajkowsky, Daniel, Pleass, Richard

IgM is the first antibody to be produced in immune responses and plays an important role in the neutralization of bacteria and viruses. Human IgM is heavily glycosylated, featuring five N-linked glycan sites on the μ chain and one on the J-chain. Gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d25cb705e68b4d04fdaae0cbf5dceb66
https://archive.lstmed.ac.uk/6821/1/Sci_Rep_7_42989.pdf

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Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash

Autor: Jochems, Simon

The morbidity and mortality related to respiratory tract diseases is enormous, with hundreds of millions of individuals afflicted and four million people dying each year. Understanding the immunological processes in the mucosa that govern outcome fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::94d28efafc625476ffe32c3f7593f7b3
https://archive.lstmed.ac.uk/6750/1/Plos_ONE_12_1_e0169805.pdf

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Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

Autor: Rufaro, Kashangura, Emily S, Sena, Taryn, Young, Paul, Garner

Publikováno v: International Journal of Epidemiology

Background\ud \ud The existing Bacillus Calmette–Guérin (BCG) vaccination provides partial protection against tuberculosis (TB). The modified vaccinia ankara virus-expressing antigen 85A (MVA85A) aims to boost BCG immunity. We evaluated the animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2ba95eb811fad01052f4476c02d7f760

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Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE)

Autor: Raiten, Daniel J., Ashour, Fayrouz A. Sakr, Ross, A. Catherine, Meydani, Simin N., Dawson, Harry D., Stephenson, Charles B., Brabin, Bernard, Suchdev, Parminder S., van Ommen, Ben, INSPIRE Consultative Grp, .

Publikováno v: The Journal of nutrition, vol 145, iss 5

An increasing recognition has emerged of the complexities of the global health agenda—specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a5a7c2bc47c9e88abf0c4ae60a6f0205
https://escholarship.org/uc/item/437672gg

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A preliminary randomized double blind placebo-controlled trial of intravenous immunoglobulin for Japanese encephalitis in Nepal

Autor: Chandeshwar Mahaseth, Sareen E. Galbraith, Jaimie S. Robinson, Małgorzata Wnęk, Penny Lewthwaite, Lance Turtle, Brian Faragher, Elizabeth Ledger, Rupa Singh, Barbara W. Johnson, Michael J. Griffiths, Sam Nightingale, Ajit Rayamajhi, Tom Solomon, Nisha Keshary Bhatta, Krishna Prasad Bista

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0122608 (2015)

BACKGROUND: Japanese encephalitis (JE) virus (JEV) is a mosquito-borne flavivirus found across Asia that is closely related to West Nile virus. There is no known antiviral treatment for any flavivirus. Results from in vitro studies and animal models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be74d09b30123449cb8667a2a3ce212

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