Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation

Autor: Dick J. van Iperen, Matthijs Luger, Barbara M. Zietek, Ben Bruyneel, Tinco J. F. Brouwer, Freek Ariese, Rob J. Limburg, Kristina B.M. Still, Nicholas R. Casewell, Kevin Jaschusch, Govert W. Somsen, Jeroen Kool, Joost C. Rosier

Publikováno v: Analytical Chemistry
Zietek, B M, Still, K B M, Jaschusch, K, Bruyneel, B, Ariese, F, Brouwer, T J F, Luger, M, Limburg, R J, Rosier, J C, V Iperen, D J, Casewell, N R, Somsen, G W & Kool, J 2019, ' Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation ', Analytical Chemistry, vol. 91, no. 16, pp. 10458-10466 . https://doi.org/10.1021/acs.analchem.9b01261
Analytical Chemistry, 91(16), 10458-10466. American Chemical Society

High-throughput screening platforms for the identification of bioactive compounds in mixtures have become important tools in the drug discovery process. Miniaturization of such screening systems may overcome problems associated with small sample volu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cff70f2d9aac50c88a575c2e68cdbb
https://archive.lstmed.ac.uk/11389/1/acs.analchem.pdf

Drugs and herbs given to prevent hepatotoxicity of tuberculosis therapy: systematic review of ingredients and evaluation studies

Autor: Binghua Huang, Qin Liu, Yang Wang, Helen Smith, Paul Garner

Publikováno v: BMC Public Health
BMC Public Health, Vol 8, Iss 1, p 365 (2008)

Background Drugs to protect the liver are frequently prescribed in some countries as part of treatment for tuberculosis. The biological rationale is not clear, they are expensive and may do harm. We conducted a systematic review to a) describe the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a647fae380e8301cd30ddca70bc2ec6c