Zobrazeno 1 - 10
of 117
pro vyhledávání: '"qv_38"'
Autor:
Bridget E Barber, Melissa Fernandez, Hardik Babubhai Patel, Catalina Barcelo, Stephen D Woolley, Harilal Patel, Stacey Llewellyn, Azrin N Abd-Rahman, Sunil Sharma, Mukul Jain, Ashok Ghoghari, Ilaria Di Resta, Aline Fuchs, Ioanna Deni, Tomas Yeo, Sachel Mok, David A Fidock, Stephan Chalon, Jörg J Möhrle, Deven Parmar, James S McCarthy, Kevinkumar Kansagra
Publikováno v:
The Lancet Infectious Diseases. 22:879-890
Background\ud \ud New antimalarials with novel mechanisms of action are needed to combat the emergence of drug resistance. Triaminopyrimidines comprise a novel antimalarial class identified in a high-throughput screen against asexual blood-stage Plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202690c309002f737190fa9311afbfc2
https://doi.org/10.1016/s1473-3099(21)00679-4
https://doi.org/10.1016/s1473-3099(21)00679-4
Autor:
Peter J. H. Webborn, Stefan Kavanagh, Andrew Cassidy, Paul M. O'Neill, Rachel H. Clare, Mark J. Taylor, Mark C. Wenlock, Neil G. Berry, W. David Hong, Darren A. N. Cook, Gemma L. Nixon, Stephen A. Ward, Paul McGillan, Suet C. Leung, Kelly L. Johnston, Louise Ford
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c7b92fc3cedccfdd23559470f0ac18
https://doi.org/10.1021/acsmedchemlett.1c00216
https://doi.org/10.1021/acsmedchemlett.1c00216
Autor:
Richard FitzGerald, Laura Dickinson, Laura Else, Thomas Fletcher, Colin Hale, Alieu Amara, Lauren Walker, Sujan Dilly Penchala, Rebecca Lyon, Victoria Shaw, William Greenhalf, Katie Bullock, Lara Lavelle-Langham, Helen Reynolds, Wendy Painter, Wayne Holman, Sean Ewings, Gareth Griffiths, Saye Khoo
ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c9670e7c8d71f3a737a267daffe19
https://eprints.soton.ac.uk/456824/
https://eprints.soton.ac.uk/456824/
Autor:
Kelly E. Dooley, Derek J. Sloan, Jan-Willem C. Alffenaar, Charles A. Peloquin, Rob E. Aarnoutse, Simone H J van den Elsen, Anne-Grete Märtson, Marieke G G Sturkenboom, Paolo Denti, Elin M. Svensson
Publikováno v:
Clinical Pharmacokinetics, 60, 6, pp. 685-710
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 60, 685-710
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 60, 685-710
Contains fulltext : 235795.pdf (Publisher’s version ) (Open Access) Tuberculosis (TB) is still the number one cause of death due to an infectious disease. Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1abb4ed666fda7be580bb31f5fe0b68
https://doi.org/10.1007/s40262-021-00997-0
https://doi.org/10.1007/s40262-021-00997-0
Publikováno v:
The Journal of Immunology Author Choice
Key Points Choice of cell line is critical for functional glycosylation of human IgG1-Fc. Sialylated IgG1-Fc monomers block influenza B only when made by CHO-K1 cells.
Abs are glycoproteins that carry a conserved N-linked carbohydrate attached t
Abs are glycoproteins that carry a conserved N-linked carbohydrate attached t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff14ea7adc6a9bcc25603c5b4553f9a2
http://europepmc.org/articles/PMC6994840
http://europepmc.org/articles/PMC6994840
Autor:
Diao, Kaiyue, Wang, Duolao, Chen, Zhongxiu, Wu, Xi, Ma, Min, Zhu, Ye, Zhang, Li, Wang, Hua, Wang, Mian, He, Sen, Li, Chen, Deng, Qiao, Yan, Ting, Wu, Tao, Tang, Lu, Huang, Baotao, Sun, Jiayu, He, Yong
Background\ud Angiotensin receptor neprilysin inhibitor (ARNI) sacubitril-valsartan has been recommended as one of the first-line therapies in heart failure with reduced ejection fraction. However, whether ARNI could benefit patients with ST-segment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5e0d6ad95372e1e5b8065f79a5eac9ed
https://archive.lstmed.ac.uk/19345/1/Diao-2021-Rationale-and-design-of-a-multicent.pdf
https://archive.lstmed.ac.uk/19345/1/Diao-2021-Rationale-and-design-of-a-multicent.pdf
Publikováno v:
Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 10, Iss 4448, p 4448 (2021)
Journal of Clinical Medicine, Vol 10, Iss 4448, p 4448 (2021)
Iron deficiency is the most common cause of anemia globally and is frequently reported in patients with underlying inflammatory conditions, such as inflammatory bowel disease (IBD) and chronic kidney disease (CKD). Ferric maltol is a new oral iron re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a51f7620909d3116637625b699742d
http://europepmc.org/articles/PMC8509126
http://europepmc.org/articles/PMC8509126
Autor:
Wu, Panpan, Tu, Borong, Liang, Jinfeng, Guo, Shengzhu, Cao, Nana, Chen, Silin, Luo, Zhujun, Li, Jiahao, Zheng, Wende, Tang, Xiaowen, Li, Dongli, Xu, Xuetao, Liu, Wenfeng, Zheng, Xi, Sheng, Zhaojun, Roberts, Adam, Zhang, Kun, Hong, Weiqian David
A series of ursolic acid (UA), oleanolic acid (OA) and 18β-glycyrrhetinic acid (GA) derivatives were synthesized by introducing a range of substituted aromatic side-chains at the C-2 position after the hydroxyl group at C-3 position was oxidized. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::1a1b41ed0d3659e608cd0eae261b2263
Autor:
Abouyannis, M, FitzGerald, R, Ngama, M, Mwangudzah, H, Nyambura, YK, Ngome, S, Riako, D, Babu, L, Lewa, F, Else, L, Dily Penchala, S, Orindi, B, Mumba, N, Kalama, B, Ndungu, FM, Adetifa, I, Khoo, S, Lalloo, DG, Casewell, NR, Hamaluba, M
Publikováno v:
Wellcome Open Research. 7:90
Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only available treatment is antivenom, which has many shortcomings including high cost, intravenous administration, and high risk of adverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471fe842370c943a7997d652cdf40fe7
https://doi.org/10.12688/wellcomeopenres.17682.1
https://doi.org/10.12688/wellcomeopenres.17682.1