Zobrazeno 1 - 4
of 4
pro vyhledávání: '"qv_195"'
Autor:
Freek J. Vonk, Govert W. Somsen, Nicholas R. Casewell, Julien Slagboom, Jeroen Kool, Laura-Oana Albulescu, Chunfang Xie
Publikováno v:
Acta Pharmaceutica Sinica B, 10(10), 1835-1845. Elsevier BV
Acta Pharmaceutica Sinica. B
Xie, C, Slagboom, J, Albulescu, L O, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2020, ' Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms ', Acta Pharmaceutica Sinica B, vol. 10, no. 10, pp. 1835-1845 . https://doi.org/10.1016/j.apsb.2020.09.005
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1835-1845 (2020)
Acta Pharmaceutica Sinica. B
Xie, C, Slagboom, J, Albulescu, L O, Somsen, G W, Vonk, F J, Casewell, N R & Kool, J 2020, ' Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms ', Acta Pharmaceutica Sinica B, vol. 10, no. 10, pp. 1835-1845 . https://doi.org/10.1016/j.apsb.2020.09.005
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1835-1845 (2020)
Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1497cb67f49ee39b4203b8d147d304cb
Autor:
Chunfang Xie, Ben Bruyneel, Jeroen Kool, Freek J. Vonk, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Nicholas R. Casewell, Kristina B.M. Still
Publikováno v:
Toxins
Xie, C, Slagboom, J, Albulescu, L O, Bruyneel, B, Still, K B M, Vonk, F J, Somsen, G W, Casewell, N R & Kool, J 2020, ' Antivenom neutralization of coagulopathic snake venom toxins assessed by bioactivity profiling using nanofractionation analytics ', Toxins, vol. 12, no. 1, 53, pp. 1-16 . https://doi.org/10.3390/toxins12010053
Volume 12
Issue 1
Toxins, 12(1):53, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
Toxins, Vol 12, Iss 1, p 53 (2020)
Xie, C, Slagboom, J, Albulescu, L O, Bruyneel, B, Still, K B M, Vonk, F J, Somsen, G W, Casewell, N R & Kool, J 2020, ' Antivenom neutralization of coagulopathic snake venom toxins assessed by bioactivity profiling using nanofractionation analytics ', Toxins, vol. 12, no. 1, 53, pp. 1-16 . https://doi.org/10.3390/toxins12010053
Volume 12
Issue 1
Toxins, 12(1):53, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
Toxins, Vol 12, Iss 1, p 53 (2020)
Venomous snakebite is one of the world&rsquo
s most lethal neglected tropical diseases. Animal-derived antivenoms are the only standardized specific therapies currently available for treating snakebite envenoming, but due to venom variation, oft
s most lethal neglected tropical diseases. Animal-derived antivenoms are the only standardized specific therapies currently available for treating snakebite envenoming, but due to venom variation, oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0d6cfe7f303847d13641f1a380cc13
https://pubmed.ncbi.nlm.nih.gov/31963329
https://pubmed.ncbi.nlm.nih.gov/31963329
Autor:
Dick J. van Iperen, Matthijs Luger, Barbara M. Zietek, Ben Bruyneel, Tinco J. F. Brouwer, Freek Ariese, Rob J. Limburg, Kristina B.M. Still, Nicholas R. Casewell, Kevin Jaschusch, Govert W. Somsen, Jeroen Kool, Joost C. Rosier
Publikováno v:
Analytical Chemistry
Zietek, B M, Still, K B M, Jaschusch, K, Bruyneel, B, Ariese, F, Brouwer, T J F, Luger, M, Limburg, R J, Rosier, J C, V Iperen, D J, Casewell, N R, Somsen, G W & Kool, J 2019, ' Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation ', Analytical Chemistry, vol. 91, no. 16, pp. 10458-10466 . https://doi.org/10.1021/acs.analchem.9b01261
Analytical Chemistry, 91(16), 10458-10466. American Chemical Society
Zietek, B M, Still, K B M, Jaschusch, K, Bruyneel, B, Ariese, F, Brouwer, T J F, Luger, M, Limburg, R J, Rosier, J C, V Iperen, D J, Casewell, N R, Somsen, G W & Kool, J 2019, ' Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation ', Analytical Chemistry, vol. 91, no. 16, pp. 10458-10466 . https://doi.org/10.1021/acs.analchem.9b01261
Analytical Chemistry, 91(16), 10458-10466. American Chemical Society
High-throughput screening platforms for the identification of bioactive compounds in mixtures have become important tools in the drug discovery process. Miniaturization of such screening systems may overcome problems associated with small sample volu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cff70f2d9aac50c88a575c2e68cdbb
https://archive.lstmed.ac.uk/11389/1/acs.analchem.pdf
https://archive.lstmed.ac.uk/11389/1/acs.analchem.pdf
Autor:
Casewell, Nicholas
To better understand envenoming and to facilitate the development of new therapies for snakebite victims, rapid, sensitive, and robust methods for assessing the toxicity of individual venom proteins are required. Metalloproteinases comprise a major p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4f28327b60033dc818760776572d9251