Zobrazeno 1 - 10
of 84 968
pro vyhledávání: '"quantitative biology"'
Extrachromosomal DNA (ecDNA) can drive oncogene amplification, gene expression and intratumor heterogeneity, representing a major force in cancer initiation and progression. The phenomenon becomes even more intricate as distinct types of ecDNA presen
Externí odkaz:
http://arxiv.org/abs/2411.14588
Autor:
Ueda, Yuika, Deguchi, Shinji
Cellular adaptation to environmental changes relies on the dynamic remodeling of cytoskeletal structures. Sarcomeres, periodic units composed mainly of actin and myosin II filaments, are fundamental to the function of the cytoskeletal architecture. I
Externí odkaz:
http://arxiv.org/abs/2411.14291
Autor:
Leguizamon-Robayo, Alexander, Jiménez-Pastor, Antonio, Tribastone, Micro, Tschaikowski, Max, Vandin, Andrea
Gaining insights from realistic dynamical models of biochemical systems can be challenging given their large number of state variables. Model reduction techniques can mitigate this by decreasing complexity by mapping the model onto a lower-dimensiona
Externí odkaz:
http://arxiv.org/abs/2411.14242
Natural products are substances produced by organisms in nature and often possess biological activity and structural diversity. Drug development based on natural products has been common for many years. However, the intricate structures of these comp
Externí odkaz:
http://arxiv.org/abs/2411.12886
Autor:
Talib, Ambreen, Shah, Rabbya Rayan, Atique, Rameen, Saeed, Hafiza Arshi, Haidar, Ayesha, Nadeem, Ayesha, Naveed, Areesha, Sharif, Javeria, Samad, Abdul
Chikungunya virus (CHIKV) is one of the most relevant arboviruses affecting public health today. It belongs to the Togaviridae family and alphavirus genus, causing an arthritogenic disease known as Chikungunya fever (CHIKF). This multifaceted disease
Externí odkaz:
http://arxiv.org/abs/2411.12779
Autor:
Wee, JunJie, Wei, Guo-Wei
The fast evolution of SARS-CoV-2 and other infectious viruses poses a grand challenge to the rapid response in terms of viral tracking, diagnostics, and design and manufacture of monoclonal antibodies (mAbs) and vaccines, which are both time-consumin
Externí odkaz:
http://arxiv.org/abs/2411.12370
Autor:
Jiao, Shuyun, Waxman, David
There are many instances, in subjects such as biology, where a population number, or related quantity, changes in discrete time. For the population number at time $n=0,1,2,\ldots$, written $x_{n}$, we show that some exactly soluble cases of $x_{n}$ c
Externí odkaz:
http://arxiv.org/abs/2411.11602
Traits are patterns of brain signals and behaviors that are stable over time but differ across individuals, whereas states are phasic patterns that vary over time, are influenced by the environment, yet oscillate around the traits. The quality of a s
Externí odkaz:
http://arxiv.org/abs/2411.12145
Colorectal cancer (CRC) poses a major public health challenge, with it being the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide as of 2024. Microsatellite instability-high (MSI-H) CRC and deficien
Externí odkaz:
http://arxiv.org/abs/2411.12123
Autor:
Ma, Yier, Tamura, Takeyuki
In computational metabolic design, it is often necessary to modify the original constraint-based metabolic networks to lead to growth-coupled production, where cell growth forces target metabolite production. However, in genome-scale models, finding
Externí odkaz:
http://arxiv.org/abs/2411.12087