Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors

Autor: Chunwei Xu, Bin Lian, Juanjuan Ou, Qian Wang, Wenxian Wang, Ke Wang, Dong Wang, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Lili Mao, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Fei Pang, Jintao Huang, Kai Wang, Fan Wu, Bingwei Xu, Liping Wang, Youcai Zhu, Li Lin, Yanru Xie, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Zhen Wang, Bin Wan, Donglai Lv, Zhanqiang Zhai, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Guansong Wang, Jiandong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Lu Si, Yuanzhi Lu, Ziming Li, Wenfeng Fang, Yong Song

Publikováno v: Global Medical Genetics, Vol 11, Iss 04, Pp 330-343 (2024)

The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair. However, FGFR gene mutations, including amplification, fusion, and mutati

Externí odkaz: https://doaj.org/article/d6d893b96da4470f8696347abc7c0079

Mesenchymal stromal cell therapies for traumatic neurological injuries

Autor: Xiujuan Wang, Qian Wang, Ziyao Xia, Ying Yang, Xunan Dai, Chun Zhang, Jiaxian Wang, Yongsheng Xu

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

Abstract Improved treatment options are urgently needed for neurological injuries resulting from trauma or iatrogenic events causing long-term disabilities that severely impact patients’ quality of life. In vitro and animal studies have provided pr

Externí odkaz: https://doaj.org/article/efb9a75a1cbc474a802e2d82921e06b2

Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

Autor: Michael S. Piepenbrink, Ahmed Magdy Khalil, Ana Chang, Ahmed Mostafa, Madhubanti Basu, Sanghita Sarkar, Simran Panjwani, Yaelyn H. Ha, Yao Ma, Chengjin Ye, Qian Wang, Todd J. Green, James L. Kizziah, Nathaniel B. Erdmann, Paul A. Goepfert, Lihong Liu, David D. Ho, Luis Martinez-Sobrido, Mark R. Walter, James J. Kobie

Publikováno v: npj Viruses, Vol 2, Iss 1, Pp 1-10 (2024)

Abstract SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. Ho

Externí odkaz: https://doaj.org/article/fc93c8dbfeef47ec8f5ad7779811e16c

Prediction of vancomycin plasma concentration in elderly patients based on multi-algorithm mining combined with population pharmacokinetics

Autor: Pan Ma, Huan Ma, Ruixiang Liu, Haini Wen, Haisheng Li, Yifan Huang, Ying Li, Lirong Xiong, Linli Xie, Qian Wang

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Abstract The pharmacokinetics of vancomycin exhibit significant inter-individual variability, particularly among elderly patients. This study aims to develop a predictive model that integrates machine learning with population pharmacokinetics (popPK)

Externí odkaz: https://doaj.org/article/e03f7f3f82924739b2076f61bbf834be

Plasmid-encoded phosphatase RapP enhances cell growth in non-domesticated Bacillus subtilis strains

Autor: Manlu Zhu, Yiheng Wang, Haoyan Mu, Fei Han, Qian Wang, Yongfu Pei, Xin Wang, Xiongfeng Dai

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract The trade-off between rapid growth and other important physiological traits (e.g., survival and adaptability) poses a fundamental challenge for microbes to achieve fitness maximization. Studies on Bacillus subtilis biology often use strains

Externí odkaz: https://doaj.org/article/e7445b28ed5a40be98e6c889e7dbec05