Zobrazeno 1 - 10
of 1 942
pro vyhledávání: '"pyruvate-kinase m2"'
Autor:
Hengdong Qu, Di Zhang, Junli Liu, Jieping Deng, Ruoyan Xie, Keke Zhang, Hongmei Li, Ping Tao, Genshu Wang, Jian Sun, Oscar Junhong Luo, Chen Qu, Wencai Ye, Jian Hong
Publikováno v:
Engineering, Vol 41, Iss , Pp 189-203 (2024)
Nonalcoholic steatohepatitis (NASH) may soon become the leading cause of end-stage liver disease worldwide with limited treatment options. Liver fibrosis, which is driven by chronic inflammation and hepatic stellate cell (HSC) activation, critically
Externí odkaz:
https://doaj.org/article/6dd95927b3ad4899bff422a9b1da6b6f
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 36, Iss , Pp 102166- (2024)
Purpose: To describe the clinical, laboratory and multimodal imaging findings in paraneoplastic autoimmune retinopathy (p-AIR) associated with anti-pyruvate kinase M2 antibody (anti-PKM2) and occult pancreatic adenocarcinoma. Observations: A 70 year
Externí odkaz:
https://doaj.org/article/1d18c3c531084e6982349063646d17aa
Autor:
Caiyan Huang, Can Xiang, Fangzhou Wang, Christophe Blecker, Zhenyu Wang, Li Chen, Dequan Zhang
Publikováno v:
Food Frontiers, Vol 5, Iss 4, Pp 1629-1641 (2024)
Abstract Phosphoglycerate kinase 1 (PGK1) and pyruvate kinase M2 (PKM2) have been identified as the postmortem meat quality biomarkers. However, the precise molecular mechanism through which they affect and regulate the development of meat quality re
Externí odkaz:
https://doaj.org/article/50d3454a33cb4f329bfca09f10ad0dd2
Autor:
Yining Xu, Xianhui Ma, Weiyu Ni, Lin Zheng, Zhongnan Lin, Yingying Lai, Ningning Yang, Zhanqiu Dai, Teng Yao, Zeyang Chen, Lifeng Shen, Haitao Wang, Long Wang, Yizheng Wu, Weiyang Gao
Publikováno v:
Advanced Science, Vol 11, Iss 47, Pp n/a-n/a (2024)
Abstract The accumulation of lactate is a rising risk factor for patients after flap transplantation. Endothelial‐to‐mesenchymal transition (EndoMT) plays a critical role in skin fibrosis. Nevertheless, whether lactate overproduction directly con
Externí odkaz:
https://doaj.org/article/19f8e773f3014b079786577b4ec6bee4
Autor:
Mohammed Jemal, Mamaru Getinet, Gashaw Azanaw Amare, Bantayehu Addis Tegegne, Temesgen Baylie, Enyew Fenta Mengistu, Enatnesh Essa Osman, Nuredin Chura Waritu, Adane Adugna
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Breast cancer (BC) is a prevalent malignant tumor in women, and its incidence has been steadily increasing in recent years. Compared with other types of cancer, it has the highest mortality and morbidity rates in women. So, it is crucial to investiga
Externí odkaz:
https://doaj.org/article/cd377126012d4aa68dde97616f009d4d
Autor:
Flama Monteiro, Vijith Vittal Shetty, Shilpa S. Shetty, Ranjitha Acharya, P. C. Suhasini, Suchetha Kumari Nalilu
Publikováno v:
Biomedical and Biotechnology Research Journal, Vol 8, Iss 2, Pp 154-159 (2024)
Background: A desired target for cancer therapy is a cancer-specific metabolism which is associated with innate or acquired therapeutic resistance, malignancies, and aggressive cancer growth. Nevertheless, these cells utilize manifold metabolic route
Externí odkaz:
https://doaj.org/article/bf8086689edf487fb98cb6882029db5e
Autor:
Guofu Li, Ziyu Xiong, Ying Li, Cong Yan, Yingying Cheng, Yuwen Wang, Jingwei Li, Zifeng Dai, Dongdong Zhang, Wenzhong Du, Chunyang Men, Changbin Shi
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Objective Glioma, a malignant primary brain tumor, is notorious for its high incidence rate. However, the clinical application of temozolomide (TMZ) as a treatment option for glioma is often limited due to resistance, which has been linked t
Externí odkaz:
https://doaj.org/article/56facc1dd2104f77bdb51978261e6b47
Akademický článek
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Autor:
Luting Yang, Chunqing Hu, Xiaowen Chen, Jie Zhang, Zhe Feng, Yanxin Xiao, Weitai He, Tingting Cui, Xin Zhang, Yang Yang, Yaling Zhang, Yaping Yan
Publikováno v:
eLife, Vol 13 (2024)
Reactive astrocytes play critical roles in the occurrence of various neurological diseases such as multiple sclerosis. Activation of astrocytes is often accompanied by a glycolysis-dominant metabolic switch. However, the role and molecular mechanism
Externí odkaz:
https://doaj.org/article/00d469dee13f454ebe34cd662c719552
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Background Patients with hypopharyngeal carcinoma (HPC) have a poor prognosis mainly because of lymphatic metastasis. This research aimed to determine the PKM2 role in lymphatic metastasis in HPC and the underlying molecular mechanism contri
Externí odkaz:
https://doaj.org/article/a609d85b15464cf7b8f21980ed266769