Zobrazeno 1 - 10
of 5 491
pro vyhledávání: '"pyridazine"'
Autor:
Hamza Assila, Younes Zaoui, Camille Kalonji Mubengayi, Walid Guerrab, Abdulsalam Alsubari, Joel T. Mague, Youssef Ramli, Mhammed Ansar
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 80, Iss 11, Pp 1221-1225 (2024)
In the title molecule, C20H18ClN3O2, the 2-chlorophenyl group is disordered to a small extent [occupancies 0.875 (2)/0.125 (2)]. The phenylacetamide moiety is nearly planar due to a weak, intramolecular C—H...O hydrogen bond. In the crystal, N—H.
Externí odkaz:
https://doaj.org/article/70695069d66f4b56b70f06c88f95c5ee
Autor:
Mouad Lahyaoui, Mouad Filali, Khadija Benamar, Riham Sghyar, Kawtar Fikri-Benbrahim, Amal Haoudi, Ahmed Mazzah, Souad El khattabi, El Mestafa El Hadrami, Youssef Kandri Rodi, Nada Kheira Sebbar
Publikováno v:
Results in Chemistry, Vol 10, Iss , Pp 101699- (2024)
In light of the increasing antibiotic resistance, it is crucial to discover new antimicrobial medications. Pyridazines are frequently investigated in research for the development of new chemical entities with enhanced therapeutic properties. Their st
Externí odkaz:
https://doaj.org/article/5b994ed0f0544968934b5f2336db6465
Autor:
Mohamed Elsawalhy, Adel A-H Abdel-Rahman, Ebtesam A. Basiony, Salma A. Ellithy, Allam A. Hassan, Eman S. Abou-Amra, Abdelhamid Ismail, Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmed M. Naglah, Nasser A. Hassan
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1407 (2024)
Background: Alzheimer’s disease (AD) is characterized by cholinergic dysfunction, making the inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) critical for improving cholinergic neurotransmission. However, the development
Externí odkaz:
https://doaj.org/article/543df1e7f9644382a5aa182dd4f75766
Akademický článek
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Autor:
Jala Bahjat Ziwar
Publikováno v:
Zanco Journal of Pure and Applied Sciences, Vol 36, Iss 1 (2024)
The eco-friendly techniques were utilized for the straightforward synthesis of new heterocyclic compounds bearing the sulfadiazine moiety by employing ultrasound irradiation techniques. Initially, sulfadiazine (1) was subjected to diazotization, foll
Externí odkaz:
https://doaj.org/article/325236c246de44128ffe7a6254119ebf
Autor:
Shixian Yan, Paul Curtis Schöpe, Joe Lewis, Kerstin Putzker, Ulrike Uhrig, Edgar Specker, Jens Peter von Kries, Peter Lindemann, Anahid Omran, Hector E. Sanchez-Ibarra, Anke Unger, Mia-Lisa Zischinsky, Bert Klebl, Wolfgang Walther, Marc Nazaré, Dennis Kobelt, Ulrike Stein
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115698- (2023)
Metastasis is directly linked to poor prognosis of cancer patients and warrants search for effective anti-metastatic drugs. MACC1 is a causal key molecule for metastasis. High MACC1 expression is prognostic for metastasis and poor survival. Here, we
Externí odkaz:
https://doaj.org/article/6858c7b995054e39a758cb5c3e16c24a
Autor:
Hamza Assila, Issam Ameziane El Hassani, Abderrazzak El Moutaouakil Ala Allah, Abdulsalam Alsubari, Joel T Mague, Youssef Ramli, MHammed Ansar
Publikováno v:
IUCrData, Vol 8, Iss 10, p x230901 (2023)
The conformation of the title molecule, C20H17ClFN3O2, is partly determined by an intramolecular C—H...O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluorobenzene ring and the acetamide group. The 2-chlorobenzyl group i
Externí odkaz:
https://doaj.org/article/7481594feb28415ea4af8723540619f5
Publikováno v:
Open Chemistry, Vol 20, Iss 1, Pp 1250-1262 (2022)
Externí odkaz:
https://doaj.org/article/c814f73db0ac42a0a8f47ce50b2c5e30
Publikováno v:
Energetic Materials Frontiers, Vol 3, Iss 3, Pp 137-145 (2022)
In this work, a fused-ring tetrazolo[1,5-b]pyridazine framework with catenated nitrogen chain was applied to develop new energetic materials with task-specific applications for different purposes. Their syntheses, characterizations and properties wer
Externí odkaz:
https://doaj.org/article/014fa910bbd744e5b55fd60cf222b50b
Autor:
Zan Xu, Joshua B. Foster, Rashelle Lashley, Xueqin Wang, Emily Benson, Grahame Kidd, Chien-liang Glenn Lin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionWe previously discovered a pyridazine derivative compound series that can improve cognitive functions in mouse models of Alzheimer’s disease. One of the advanced compounds from this series, LDN/OSU-0215111-M3, was selected as the precli
Externí odkaz:
https://doaj.org/article/35750ae5a5f74f5e9ac22f471fdb6d6b