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Autor:
Tal Burstyn-Cohen, Avi Maimon
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-9 (2019)
Abstract The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in this special issue. This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK – comprising the TAM family of recept
Externí odkaz:
https://doaj.org/article/54cd452784124cfa8a118d877e14ee3d
Autor:
Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D. Sood, Hong Wang, Xinyan Zhao, Molly H. Jenkins, Qingyong Ji, Youbin Wang, David P. Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G. Derner, Qi An, Christel Iffland, Joern-Peter Halle
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctio
Externí odkaz:
https://doaj.org/article/f2420cb2a82040deb84b2167b543e3fe
Autor:
Miranda L. Bader Lange, Daret St. Clair, William R. Markesbery, Christa M. Studzinski, M. Paul Murphy, D. Allan Butterfield
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 1, Pp 104-115 (2010)
Using APPNLh/APPNLh x PS-1P246L/PS-1P246L human double knock-in (APP/PS-1) mice, we examined whether phosphatidylserine (PtdSer) asymmetry is significantly altered in brain of this familial Alzheimer disease mouse model in an age-dependent manner as
Externí odkaz:
https://doaj.org/article/98b19aae5a2c40e69b84eb51b22f708a
Autor:
Miranda L. Bader Lange, Giovanna Cenini, Marta Piroddi, Hafiz Mohmmad Abdul, Rukhsana Sultana, Francesco Galli, Maurizio Memo, D. Allan Butterfield
Publikováno v:
Neurobiology of Disease, Vol 29, Iss 3, Pp 456-464 (2008)
Oxidative stress, a hallmark of Alzheimer disease (AD), has been shown to induce lipid peroxidation and apoptosis disrupting cellular homeostasis. Normally, the aminophospholipid phosphatidylserine (PtdSer) is asymmetrically distributed on the cytoso
Externí odkaz:
https://doaj.org/article/b61adca706b54e4d985f46e5379189f4
Publikováno v:
The Journal of Biological Chemistry
ATP11C is a member of the P4-ATPase flippase family that mediates translocation of phosphatidylserine (PtdSer) across the lipid bilayer. In order to characterize the structure and function of ATP11C in a model natural lipid environment, we revisited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df73493370830dd8a57410478e8a28c0
https://pubmed.ncbi.nlm.nih.gov/34922944
https://pubmed.ncbi.nlm.nih.gov/34922944
Autor:
Jimmy D. Dikeakos, Cassandra R Edgar, Andrés Finzi, S. M. Mansour Haeryfar, Alexa Galbraith, Jérémie Prévost, Mitchell J. Mumby, Rajesh Abraham Jacob, Frank Kirchhoff, Antony Lurie, Steven M. Trothen
Publikováno v:
The Journal of Biological Chemistry
Prolonged immune activation drives the upregulation of multiple checkpoint receptors on the surface of virus-specific T cells, inducing their exhaustion. Reversing HIV-1-induced T cell exhaustion is imperative for efficient virus clearance; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4498fbba12fc0bc9e4265261297f405
http://europepmc.org/articles/PMC8390549
http://europepmc.org/articles/PMC8390549
Autor:
Teddy Ang, Ahrathy Selathurai, Angus Lindsay, Victoria C. Foletta, Gunveen Kaur, Clinton R. Bruce, Sean L. McGee, Micah L Burch, Shaun A. Mason, Steven Hamley, Paul A. Della Gatta, Damien L. Callahan, Grzegorz M Kowalski, Annie R Curtis
Publikováno v:
Molecular Metabolism, Vol 27, Iss, Pp 33-46 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Phosphatidylethanolamine (PtdEtn) is a major phospholipid in mammals. It is synthesized via two pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum and the phosphatidylserine (PtdSer) decarboxylase (PSD) pathway in the mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d48d5b907b2317df0cc50f55e04300
http://www.sciencedirect.com/science/article/pii/S2212877819302698
http://www.sciencedirect.com/science/article/pii/S2212877819302698
Autor:
Barth, Nicole Doris
In the human body, billions of cells die every day, a cell death that is termed apoptosis. Clearance of these cells is crucial for the maintenance of homeostasis and dysregulation leads to inflammation and cancer. The extent of apoptosis within tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______463::97fc20f9db57fbbf7a1a091ebf97f13f
https://hdl.handle.net/1842/37660
https://hdl.handle.net/1842/37660
Publikováno v:
Fundamental Research
The sudden outbreak of COVID-19 has once again shrouded people in the enormous threat of RNA virus. Extracellular vesicles (EVs), eukaryotic cells-derived small bi-layer vesicles mainly consisting of exosomes and microvesicles, share many properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f206f19d918f7ee813c1621531120b9
http://europepmc.org/articles/PMC7906858
http://europepmc.org/articles/PMC7906858