Zobrazeno 1 - 10
of 841
pro vyhledávání: '"ptbp1"'
Autor:
Jia-Yi Hou, Xiao-Ling Wang, Hai-Jiao Chang, Xi-Xing Wang, Shu-Lan Hao, Yu Gao, Gang Li, Li-Juan Gao, Fu-Peng Zhang, Zhi-Jie Wang, Jian-Yun Shi, Ning Li, Ji-Min Cao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Aerobic glycolysis is a tumor cell phenotype and a hallmark in cancer research. The alternative splicing of the pyruvate kinase M (PKM) gene regulates the expressions of PKM1/2 isoforms and the aerobic glycolysis of tumors. Polypy
Externí odkaz:
https://doaj.org/article/f26da8a8759b4b1fb5248c75ed1ab024
Autor:
Yusuke Fukui, Ryuta Morihara, Xinran Hu, Yumiko Nakano, Taijun Yunoki, Mami Takemoto, Koji Abe, Toru Yamashita
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The therapeutic potential of suppressing polypyrimidine tract-binding protein 1 (Ptbp1) messenger RNA by viral transduction in a post-stroke dementia mouse model has not yet been examined. In this study, 3 days after cerebral ischemia, we in
Externí odkaz:
https://doaj.org/article/6b5426c28811413cb36569b532e2f705
Autor:
Shimin Wang, Xiaolin Wang, Changhong Qin, Ce Liang, Wei Li, Ai Ran, Qiang Ma, Xiaojuan Pan, Feifei Yang, Junwu Ren, Bo Huang, Yuying Liu, Yuying Zhang, Haiping Li, Hao Ning, Yan Jiang, Bin Xiao
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-22 (2024)
Abstract Background Gastric cancer (GC) is a prevalent malignant tumor, and the RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) has been identified as a crucial factor in various tumor types. Moreover, abnormal autophagy levels hav
Externí odkaz:
https://doaj.org/article/c684e77ecfd64ecdb2eefc67da6dc1c0
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 67, Iss 3, Pp 510-517 (2024)
Context: Helicobacter pylori (H. pylori), a spiral-shaped bacterium, is closely associated with chronic, progressive gastric mucosal damage, gastric atrophy, and even gastric cancer (GC). An increasing number of studies have addressed the correlation
Externí odkaz:
https://doaj.org/article/29ee3991b9c342d9a7ee461c8cca4b0f
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7730-7744 (2024)
Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and post-transcriptional regulation. Moreover, PTBP1 has been implicated as a causal factor in tumorigenesis. However, the involvement of PTBP1 in cellular senescence,
Externí odkaz:
https://doaj.org/article/a0eb45032d5a44c6b115e59e7a4a8e32
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
Background Lung adenocarcinoma is the most common type of lung cancer, accounting for approximately 40% of all lung cancer cases, and has the highest incidence among lung cancer subtypes. Recent studies have suggested that long non-coding RNAs (lncRN
Externí odkaz:
https://doaj.org/article/e9ef9bd3a26f47c69708a304f406b336
Autor:
Haixia He, Qianghua Zhou, Yangjie Zhang, Yi Li, Lin Ding, Ting Shen, Sen Liu, Shengmeng Peng, Ming Huang, Hua Zhou, Liang Cheng, Ruihui Xie, Qiang Zhang, Junlin Lu, Liting Li, Jing Yang, Shoumin Bai, Tianxin Lin, Xu Chen
Publikováno v:
Advanced Science, Vol 11, Iss 42, Pp n/a-n/a (2024)
Abstract Radiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression. Nonetheless, the role of splicing fac
Externí odkaz:
https://doaj.org/article/b0738722bda649a598d00d242033a4cb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract PTBP1 is an oncogene that regulates the splicing of precursor mRNA. However, the relationship between PTBP1 expression and gene methylation, cancer prognosis, and tumor microenvironment remains unclear. The expression profiles of PTBP1 acros
Externí odkaz:
https://doaj.org/article/82c0c5fab0b74d52a3645dcbcdce1fd4
Autor:
Liang Cheng, Chenwei Yang, Junlin Lu, Ming Huang, Ruihui Xie, Sarah Lynch, Justin Elfman, Yuhang Huang, Sen Liu, Siting Chen, Baoqing He, Tianxin Lin, Hui Li, Xu Chen, Jian Huang
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract Chimeric RNAs, distinct from DNA gene fusions, have emerged as promising therapeutic targets with diverse functions in cancer treatment. However, the functional significance and therapeutic potential of most chimeric RNAs remain unclear. Her
Externí odkaz:
https://doaj.org/article/9c8720ea7f8f4b6ca77e0c3abbc4c3d0
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 2, Pp 175-197 (2024)
Background & Aims: Circ-CCT2 (hsa_circ_0000418) is a novel circular RNA that stems from the CCT2 gene. However, the expression of circ-CCT2 and its roles in hepatoblastoma are unknown. Our study aims to study the circ-CCT2 roles in hepatoblastoma dev
Externí odkaz:
https://doaj.org/article/ea5e869d22af42fba889e65f3c50d085