Impaired planning in patients with obsessive-compulsive disorder and unaffected first-degree relatives: Evidence for a cognitive endophenotype

Autor: Rosa Grützmann, Michael Wagner, Anja Riesel, Julia Klawohn, Leonhard Lennertz, Norbert Kathmann, Stephan Heinzel, Christian Kaufmann, Katharina Bey

Publikováno v: Journal of anxiety disorders 57, 24-30 (2018). doi:10.1016/j.janxdis.2018.05.009

Patients with obsessive-compulsive disorder (OCD) show deficient planning capacity in the Tower of London (TOL) problem solving task. Preliminary evidence for similar deficits in unaffected first-degree relatives suggests that impaired planning may c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f112f4888756ec477da70b4c636f628
https://doi.org/10.1016/j.janxdis.2018.05.009

Association of Cerebral Amyloid-Β Aggregation With Cognitive Functioning in Persons Without Dementia

Autor: Myriam Alexander, Steven E. Arnold, Stephanie J.B. Vos, Viviana Lisetti, Gunhild Waldemar, Marzena Zboch, David A. Wolk, Sebastiaan Engelborghs, Sabine Hellwig, Adrian Ivanoiu, José Luis Molinuevo, Duk L. Na, Sebastian Köhler, Elisabeth Kapaki, Catarina R. Oliveira, Enrica Cavedo, Ina S. Almdahl, Karine Madsen, Mark A. Mintun, Frans R.J. Verhey, Juha O. Rinne, John C. Morris, Hanne Struyfs, George P. Paraskevas, Oliver Peters, Ann D. Cohen, Philip Scheltens, Willemijn J. Jansen, Linda J C van Waalwijk van Doorn, Eckart Rüther, Sanna-Kaisa Herukka, Osama Sabri, Mark Forrest Gordon, Yvonne Freund-Levi, Rik Vandenberghe, Lucrezia Hausner, Marie Sarazin, Kristian Steen Frederiksen, Inês Baldeiras, William E. Klunk, Susan M. Landau, Timo Grimmer, Lutz Froelich, Betty M. Tijms, Dong Young Lee, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Charlotte E. Teunissen, Kaj Blennow, Mony J. de Leon, Christopher C. Rowe, Alberto Lleó, Uroš Rot, Pascual Sánchez-Juan, Daniel Alcolea, Henryk Barthel, Wiesje M. van der Flier, Olga Meulenbroek, Tomasz Gabryelewicz, Tormod Fladby, Andrew B. Newberg, Åsa K. Wallin, Marcel M. Verbeek, Lucilla Parnetti, Bart N.M. van Berckel, Vincent Mok, Oskar Hansson, Victor L. Villemagne, David J. Brooks, Helmut Hildebrandt, Koen Van Laere, Dag Aarsland, Inez H.G.B. Ramakers, Harald Hampel, Elena Chipi, Henrik Zetterberg, Erik Stomrud, Hilkka Soininen, Juan Fortea, Gil D. Rabinovici, Anders Wallin, Vincent Camus, Gayan Perera, Julius Popp, Pieter Jelle Visser, Magda Tsolaki, Johannes Kornhuber, Anne M. Fagan, Niklas Mattsson, William J. Jagust, Luiza Spiru, Hanne M. Møllergård, Adam S. Fleisher, Isabel Santana, Jens Wiltfang, Jan Marcusson, Alexander Drzezga, Giovanni B. Frisoni, Catherine M. Roe, Mark A. van Buchem, Norman Koglin, Johannes Schröder, Pauline Aalten, Olymbia Gkatzima, Lorena Rami, Wolfgang Maier, Agneta Nordberg, Alexandre de Mendonça, Gerald Novak, Gaël Chételat, Arto Nordlund, Milica G. Kramberger, Rik Ossenkoppele, Barbara Mroczko, Kewei Chen, Eloy Rodríguez-Rodríguez, Stefan Förster, Sang W. Seo, Philipp T. Meyer

Publikováno v: JAMA psychiatry 75(1), 84 (2018). doi:10.1001/jamapsychiatry.2017.3391
JAMA Psychiatry, 75, 1, pp. 84-95
JAMA Psychiatry, 75, 84-95
JAMA Psychiatry
JAMA Psychiatry, 75(1), 84-95. American Medical Association
Amyloid Biomarker Study Group 2018, ' Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia ', JAMA Psychiatry, vol. 75, no. 1, pp. 84-95 . https://doi.org/10.1001/jamapsychiatry.2017.3391
JAMA psychiatry
JAMA Psychiatry, Vol. 75, No 1 (2018) pp. 84-95

Contains fulltext : 190311.pdf (Publisher’s version ) (Closed access) Importance: Cerebral amyloid-beta aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abc7da7cde61d1aaac7ed95e65d08b2
https://ruj.uj.edu.pl/xmlui/handle/item/109797

Development and evaluation of the content validity, practicability and feasibility of the Innovative dementia-oriented Assessment system for challenging behaviour in residents with dementia

Autor: Sabine Bartholomeyczik, Daniela Holle, Margareta Halek

Publikováno v: BMC Health Services Research
BMC Health Services Research, Vol 17, Iss 1, Pp 1-26 (2017)
BMC health services research 17(1), 554 (2017). doi:10.1186/s12913-017-2469-8

Background One of the most difficult issues for care staff is the manifestation of challenging behaviour among residents with dementia. The first step in managing this type of behaviour is analysing its triggers. A structured assessment instrument ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe780fc83091ee55ccdab52abd961840
https://www.ncbi.nlm.nih.gov/pubmed/28806934

Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism

Autor: Lutz Frölich, Stefan J. Teipel, Michael Hüll, Alfredo Ramirez, Maria A. de Souza Silva, Sandra Schäble, Andrea Rotter, Christian P. Müller, Wolfgang Maier, Johannes Schröder, Teresa Biermann, Frank Jessen, Bernd Lenz, Johannes Kornhuber, Oliver Peters, Oliver Gruber, Joseph P. Huston

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 110(37), 15097-15102 (2013). doi:10.1073/pnas.1306884110

Impaired learning and memory performance is often found in aging as an early sign of dementia. It is associated with neuronal loss and reduced functioning of cholinergic networks. Here we present evidence that the neurokinin3 receptors (NK3-R) and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f060877cf72da5df0e9ff0f9f6a680
https://doi.org/10.1073/pnas.1306884110

Alzheimer's Disease Genes and Cognition in the Nondemented General Population

Autor: Albert Hofman, M. Arfan Ikram, Meike W. Vernooij, Monique M.B. Breteler, Benjamin F.J. Verhaaren, André G. Uitterlinden, Cornelia M. van Duijn, Peter J. Koudstaal

Publikováno v: Biological psychiatry 73(5), 429-434 (2013). doi:10.1016/j.biopsych.2012.04.009
Biological Psychiatry, 73(5), 429-434. Elsevier Inc.

Background Genome-wide association studies have established 11 genes for late-onset Alzheimer's disease (AD). We investigated whether these genes jointly affect cognition in a nondemented population and improve prediction of AD. Methods In 5171 nonde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fb08ccfe6fc1563deb786560b584e2
https://pure.eur.nl/en/publications/dac187e4-16fe-414e-9299-2ea6945a5b16