Zobrazeno 1 - 10
of 607
pro vyhledávání: '"pssm"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background Drug targets in living beings perform pivotal roles in the discovery of potential drugs. Conventional wet-lab characterization of drug targets is although accurate but generally expensive, slow, and resource intensive. Therefore,
Externí odkaz:
https://doaj.org/article/8ebf9fc9fa294a0fb20213c773537ba9
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Understanding coding mutations is important for many applications in biology and medicine but the vast mutation space makes comprehensive experimental characterisation impossible. Current predictors are often computationally intensive and di
Externí odkaz:
https://doaj.org/article/bc8380aaa9904dfab0d6a09d81085d86
Akademický článek
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Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background The prediction of protein secondary structures is a crucial and significant step for ab initio tertiary structure prediction which delivers the information about proteins activity and functions. As the experimental methods are exp
Externí odkaz:
https://doaj.org/article/b7928a31b15a42be8b44f1f25fd1c79c
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
DNA-binding proteins (DBP) play an essential role in the genetics and evolution of organisms. A particular DNA sequence could provide underlying therapeutic benefits for hereditary diseases and cancers. Studying these proteins can timely and effectiv
Externí odkaz:
https://doaj.org/article/1c1de383147448b784300afc42278da3
Akademický článek
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Publikováno v:
F1000Research, Vol 11 (2022)
The position weight matrix, also called the position-specific scoring matrix, is the commonly accepted model to quantify the specificity of transcription factor binding to DNA. Position weight matrices are used in thousands of projects and software t
Externí odkaz:
https://doaj.org/article/5175c98fcccf42fb8b8924bb53449468
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Cancer is one of the major causes of death worldwide. To treat cancer, the use of anticancer peptides (ACPs) has attracted increased attention in recent years. ACPs are a unique group of small molecules that can target and kill ca
Externí odkaz:
https://doaj.org/article/196098b10a1141a6bb857379654d9f94
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Moonlighting proteins (MPs) are a subclass of multifunctional proteins in which more than one independent or usually distinct function occurs in a single polypeptide chain. Identification of unknown cellular processes, understandi
Externí odkaz:
https://doaj.org/article/3e9094fd20484464a74b2695b2d5df97
Publikováno v:
BioData Mining, Vol 14, Iss 1, Pp 1-17 (2021)
Abstract Background Prediction of novel Drug–Target interactions (DTIs) plays an important role in discovering new drug candidates and finding new proteins to target. In consideration of the time-consuming and expensive of experimental methods. The
Externí odkaz:
https://doaj.org/article/a59106d83a8448d695e418eebdd2628f