Zobrazeno 1 - 10
of 939
pro vyhledávání: '"pseudokinase"'
Akademický článek
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Akademický článek
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Autor:
Xiaoling Wang, Tiantian Cui, Hao Yan, Lingping Zhao, Ruge Zang, Hongyu Li, Haiyang Wang, Biao Zhang, Junnian Zhou, Yiming Liu, Wen Yue, Jiafei Xi, Xuetao Pei
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37463- (2024)
Tribbles pseudokinase 3 (TRIB3) expression significantly increases during terminal erythropoiesis in vivo. However, we found that TRIB3 expression remained relatively low during human embryonic stem cell (hESC) erythropoiesis, particularly in the lat
Externí odkaz:
https://doaj.org/article/397191ba5f7b480cad7e58d8d3b619bb
Publikováno v:
Cancer Medicine, Vol 13, Iss 16, Pp n/a-n/a (2024)
Abstract Objectives Glioblastoma (GBM) is the most aggressive of intracranial gliomas. Despite the maximal treatment intervention, the median survival rate is still about 14–16 months. Nuclear receptor‐binding protein 1 (NRBP1) has a potential gr
Externí odkaz:
https://doaj.org/article/5f18d244c4f94f5c964d4de000694149
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Objective The superfamily of protein kinases features a common Protein Kinase-like (PKL) three-dimensional fold. Proteins with PKL structure can also possess enzymatic activities other than protein phosphorylation, such as AMPylation or glut
Externí odkaz:
https://doaj.org/article/8bcca83bf93b44a9abacf08ffdecd44f
Publikováno v:
Biomolecules & Biomedicine (2024)
Diabetic nephropathy (DN) is a severe complication of prolonged diabetes, impacting millions worldwide with an increasing incidence. This study investigates the role of tribbles pseudokinase 3 (TRIB3), a protein implicated in the progression of DN, f
Externí odkaz:
https://doaj.org/article/e7238f0482aa4a259640a76671227bfa
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background As a member of the Janus kinase (JAK) family, which includes JAK1, JAK2 and JAK3, tyrosine kinase 2 (TYK2) plays an important role in signal transduction and immune system regulation. Moreover, it is also involved in the developme
Externí odkaz:
https://doaj.org/article/71a93a7ec6444f7cb54f72fe8c4c1cb3
Publikováno v:
Genes and Diseases, Vol 10, Iss 4, Pp 1702-1713 (2023)
How PD-L1 expression is regulated in cancer is poorly understood. Here, we report that the ATP-binding activity of ERBB3 pseudokinase regulates PD-L1 gene expression in colorectal cancers (CRCs). ERBB3 is one of the four members of the EGF receptor f
Externí odkaz:
https://doaj.org/article/4990cf4cc5a949cb8f6fadeace638bc5
Autor:
Huadong Wu, Zhenzhen Fu, Hong Li, Feifei Fang, Bin He, Yujie Ye, Heyong Wu, Dong Xu, Haoran Zheng, Qiang Zhang
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
ObjectiveAs a pseudokinase, Tribbles Pseudokinase 3 (TRIB3) is implicated in a wide array of biological processes, including cell signal transduction, metabolic regulation, stress responses, and immune regulation. While its significant role in the im
Externí odkaz:
https://doaj.org/article/7f24044aadce41cb8d6a688642a824c3
Publikováno v:
eLife, Vol 12 (2023)
The Hedgehog (Hh) family of secreted proteins governs embryonic development and adult tissue homeostasis through the Gli family of transcription factors. Gli is thought to be activated at the tip of primary cilium, but the underlying mechanism has re
Externí odkaz:
https://doaj.org/article/3e88d51026194aef89a44b61da39ed62