Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Autor: Magnus Johannesson, André G. Uitterlinden, Cornelius A. Rietveld, Nicholas J. Timpson, Sarah E. Medland, Tõnu Esko, Beben Benyamin, Ian J. Deary, Sven J. van der Lee, Christiaan de Leeuw, Nicholas G. Martin, Matt McGue, Cornelia M. van Duijn, David C. Liewald, Patrick Turley, Nancy L. Pedersen, Paul Lichtenstein, Jaime Derringer, Frank C. Verhulst, James J. Lee, Carla A. Ibrahim-Verbaas, Dalton Conley, Philipp Koellinger, John M. Starr, Tune H. Pers, Christopher F. Chabris, David Cesarini, David Laibson, Edward L. Glaeser, Najaf Amin, Olga Rostapshova, Maciej Trzaskowski, Juha Karjalainen, Mary E. Ward, Caroline Hayward, Valur Emilsson, Patrik K. E. Magnusson, Henning Tiemeier, Daniel J. Benjamin, Robert Plomin, David J. Porteous, George Davey Smith, Michael B. Miller, Margaret J. Wright, Fernando Rivadeneira, Vincent W. V. Jaddoe, Anna A. E. Vinkhuyzen, William G. Iacono, Lude Franke, Peter M. Visscher, Rudolf S N Fehrmann, Gail Davies, Andrew D. Johnson, Steven Pinker, Riccardo E. Marioni, Blair H. Smith, George McMahon, Danielle Posthuma, Narelle K. Hansell

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13790-13794. National Academy of Sciences
Proceedings of the National Academy of Sciences
Rietveld, C A, Esko, T, Davies, G, Pers, T H, Turley, P, Benyamin, B, Chabris, C F, Emilsson, V, Johnson, A D, Lee, J J, de Leeuw, C A, Marioni, R E, Medland, S E, Miller, M B, Rostapshova, O, van der Lee, S J, Vinkhuyzen, A A, Amin, N, Conley, D, Derringer, J, van Duijn, C M, Fehrmann, R, Franke, L, Glaeser, E L, Hansell, N K, Hayward, C, Lacono, W G, Ibrahim-Verbaas, C A, Jaddoe, V, Karjalainen, J, Laibson, D, Lichtenstein, P, Liewald, D C, Magnusson, P K, Martin, N G, McGue, M, McMahon, G, Pedersen, N L, Pinker, S, Porteous, D J, Posthuma, D, Rivadeneira, F, Smith, B H, Starr, J M, Tiemeier, H, Timpson, N J, Trzaskowski, M, Uitterlinden, A G, Verhulst, F C, Ward, M E, Wright, M J, Davey Smith, G, Deary, I J, Johannesson, M, Plomin, R, Visscher, P M, Benjamin, D J, Cesarini, D & Koellinger, P D 2014, ' Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. ', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 38, pp. 13790-13794 . https://doi.org/10.1073/pnas.1404623111
Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13790-13794. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13790-13794. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the U.S.A., 111(38), 13790-13794. National Academy of Sciences

We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxyphenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736)

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https://research.vumc.nl/en/publications/c9d48016-8947-43db-ae96-fc838cafed02