Zobrazeno 1 - 10
of 75
pro vyhledávání: '"protides"'
Autor:
Kuriki Y; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Sogawa M; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Komatsu T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Kawatani M; Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.; Department of Life Science and Technology, Tokyo Institute of Technology, 4259, Nagatsuda-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan., Fujioka H; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.; Department of Life Science and Technology, Tokyo Institute of Technology, 4259, Nagatsuda-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan., Fujita K; Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Ueno T; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Hanaoka K; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Kojima R; Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Hino R; Department of Sports and Health Science, Daito Bunka University, 560 Iwadono, Higashimatsuyama, Saitama 355-8501, Japan., Ueo H; Ueo Breast Cancer Hospital, 1-3-5 Futamatacho, Oita, Oita 870-0887, Japan., Ueo H; Ueo Breast Cancer Hospital, 1-3-5 Futamatacho, Oita, Oita 870-0887, Japan., Kamiya M; Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.; Department of Life Science and Technology, Tokyo Institute of Technology, 4259, Nagatsuda-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.; Living Systems Materialogy (LiSM) Research Group, International Research Frontiers Initiative (IRFI), Tokyo Institute of Technology, 4259, Nagatsuda-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan., Urano Y; Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.; Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2024 Jan 10; Vol. 146 (1), pp. 521-531. Date of Electronic Publication: 2023 Dec 18.
Autor:
Fang SS; Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China., Hu X; Department of Rehabilitation Medicine, Shanghai Institute of Rehabilitation with Integrated Western and Chinese Traditional Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Li MH; Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.; Xiangfu Laboratory, Jiashan 314102, China., Qi S; Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200217, China., Xie T; Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China., Wang JB; Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.; Xiangfu Laboratory, Jiashan 314102, China., Yao HQ; Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China., Zhang J; Department of Rehabilitation Medicine, Shanghai Institute of Rehabilitation with Integrated Western and Chinese Traditional Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Zhang JH; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai 200032, China., Zhu L; Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200217, China., Shang M; Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.; Xiangfu Laboratory, Jiashan 314102, China.
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2024 Nov 13; Vol. 146 (45), pp. 31339-31347. Date of Electronic Publication: 2024 Nov 04.
Autor:
Glockzin KM; Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States., Narindoshvili T; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States., Raushel FM; Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.; Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, United States.
Publikováno v:
Biochemistry [Biochemistry] 2024 Jul 16; Vol. 63 (14), pp. 1774-1782. Date of Electronic Publication: 2024 Jul 03.
Autor:
Li J; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States., de Melo Jorge DM; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Wang W; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States., Sun S; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States.; Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States., Frum T; Department of Internal Medicine, Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Hang YA; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States., Liu Y; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States., Zhou X; Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States., Xiao J; Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States., Wang X; Department of Pharmaceutical Sciences, Northeast Ohio Medical University College of Pharmacy, Rootstown, Ohio 44272, United States., Spence JR; Department of Internal Medicine, Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, Michigan 48109, United States., Wobus CE; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Zhu HJ; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 May 09; Vol. 67 (9), pp. 7470-7486. Date of Electronic Publication: 2024 May 01.
Autor:
Gniech T; Institute of Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany., Humboldt A; Institute of Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany., Keith KA; Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA., James SH; Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA., Richert C; Institute of Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany.
Publikováno v:
ChemMedChem [ChemMedChem] 2024 Apr 16; Vol. 19 (8), pp. e202300661. Date of Electronic Publication: 2024 Feb 07.
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Compounds with a phosphonate group, i.e., –P(O)(OH)2 group attached directly to the molecule via a P-C bond serve as suitable non-hydrolyzable phosphate mimics in various biomedical applications. In principle, they often inhibit enzymes utilizing v
Externí odkaz:
https://doaj.org/article/2b511f5e834d4bc5b8956fd6276991f7
Autor:
Markušová, Katarína
This diploma thesis focuses on the synthesis of novel prodrugs of tenofovir, one of the main components of medications against human immunodeficiency virus (HIV) infection. The design of the compounds is based on the concept of ProTides and takes ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2186::f18226b004b36d559c30834cd868b3eb
http://www.nusl.cz/ntk/nusl-527806
http://www.nusl.cz/ntk/nusl-527806
Autor:
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell
Publikováno v:
Molecules, Vol 25, Iss 3, p 704 (2020)
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success. Despite the translation
Externí odkaz:
https://doaj.org/article/2e11479901e84c4b8e768815c561ddf1
Autor:
Jean A. Bernatchez, Michael Coste, Sungjun Beck, Grace A. Wells, Lucas A. Luna, Alex E. Clark, Zhe Zhu, David Hecht, Jeremy N. Rich, Christal D. Sohl, Byron W. Purse, Jair L. Siqueira-Neto
Publikováno v:
Viruses, Vol 11, Iss 4, p 365 (2019)
Zika virus (ZIKV), an emerging flavivirus that causes neurodevelopmental impairment to fetuses and has been linked to Guillain-Barré syndrome continues to threaten global health due to the absence of targeted prophylaxis or treatment. Nucleoside ana
Externí odkaz:
https://doaj.org/article/8bc9c934f52a44aa9e549f9117d62e4d
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.