Zobrazeno 1 - 10
of 1 107
pro vyhledávání: '"proteolytic processing"'
Autor:
Claire D McWhite, Wisath Sae-Lee, Yaning Yuan, Anna L Mallam, Nicolas A Gort-Freitas, Silvia Ramundo, Masayuki Onishi, Edward M Marcotte
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 933-951 (2024)
Abstract The variability of proteins at the sequence level creates an enormous potential for proteome complexity. Exploring the depths and limits of this complexity is an ongoing goal in biology. Here, we systematically survey human and plant high-th
Externí odkaz:
https://doaj.org/article/6953cb1a1b2148c5b640f8b922f7ea45
Autor:
Monika Pepelnjak, Rivkah Rogawski, Galina Arkind, Yegor Leushkin, Irit Fainer, Gili Ben-Nissan, Paola Picotti, Michal Sharon
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 403-427 (2024)
Abstract For years, proteasomal degradation was predominantly attributed to the ubiquitin-26S proteasome pathway. However, it is now evident that the core 20S proteasome can independently target proteins for degradation. With approximately half of th
Externí odkaz:
https://doaj.org/article/2a18edd0175d45c28478f28b1ded6b6d
Autor:
Efrat Kessler
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8444 (2024)
Pseudomonas aeruginosa is an opportunistic pathogen that causes severe infections in compromised hosts. P. aeruginosa infections are difficult to treat because of the inherent ability of the bacteria to develop antibiotic resistance, secrete a variet
Externí odkaz:
https://doaj.org/article/9c45891181674d41a3aade8e7c378aad
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Nucleobindin-2 (Nucb2) is a multidomain protein that, due to its structure, participates in many physiological processes. It was originally identified in several regions of the hypothalamus. However, more recent studies have redef
Externí odkaz:
https://doaj.org/article/97793ee850894980bc7cf3f6587558c0
Autor:
Andreu Matamoros-Angles, Behnam Mohammadi, Feizhi Song, Mohsin Shafiq, Santra Brenna, Berta Puig, Markus Glatzel, Hermann C Altmeppen
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 9, Pp 1869-1875 (2023)
In the last decades, the role of the prion protein (PrP) in neurodegenerative diseases has been intensively investigated, initially in prion diseases of humans (e.g., Creutzfeldt-Jakob disease) and animals (e.g., scrapie in sheep, chronic wasting dis
Externí odkaz:
https://doaj.org/article/f326dae2cbf2448ba7826c92752c6b8d
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
More than sesquicentennial years of malarial research, however the unique malarial parasite, Plasmodium still bewilders us with its atypical characteristic features. Elimination strategies, deeper knowledge of the parasite biology and pathways can he
Externí odkaz:
https://doaj.org/article/f716244f317e407a9fced36eb675445a
Autor:
Anastasia D. Teplova, Artemii A. Pigidanov, Marina V. Serebryakova, Sergei A. Golyshev, Raisa A. Galiullina, Nina V. Chichkova, Andrey B. Vartapetian
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16527 (2023)
Soluble chaperones residing in the endoplasmic reticulum (ER) play vitally important roles in folding and quality control of newly synthesized proteins that transiently pass through the ER en route to their final destinations. These soluble residents
Externí odkaz:
https://doaj.org/article/26696a2523984976aea1fe8044dd3892
Akademický článek
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Akademický článek
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Autor:
Peter A. Bell, Sophia Scheuermann, Florian Renner, Christina L. Pan, Henry Y. Lu, Stuart E. Turvey, Frédéric Bornancin, Catherine H. Régnier, Christopher M. Overall
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4717-4732 (2022)
We developed a bioinformatics-led substrate discovery workflow to expand the known substrate repertoire of MALT1. Our approach, termed GO-2-Substrates, integrates protein function information, including GO terms from known substrates, with protein se
Externí odkaz:
https://doaj.org/article/ee670d72d28541c29c6af4f17e092816