Zobrazeno 1 - 10 of 32 pro vyhledávání: '"protein-tyrosine kinase (tyrosine kinase)"'
1
Activity-dependent conformational transitions of the insulin receptor–related receptor
Autor: Eduard V. Bocharov, Alexander N. Orsa, Alexander G. Petrenko, I. E. Deyev, Alexander S. Goryashchenko, Natalia V. Kuzmina, Ekaterina D. Mileshina, A. A. Mozhaev, Oleg V. Batishchev
Publikováno v: The Journal of Biological Chemistry
The insulin receptor (IR), insulin-like growth factor 1 receptor (IGF-1R), and insulin receptor-related receptor (IRR) form a mini family of predimerized receptor-like tyrosine kinases. IR and IGF-1R bind to their peptide agonists triggering metaboli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f854f8cc3042abb24bde19183c9956d
https://doi.org/10.1016/j.jbc.2021.100534
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2
Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)
Autor: Anjali Pandey, Christopher A. O’Callaghan, Craig E. Hughes, Johannes A. Eble, Uma Sinha, Steve P. Watson
Publikováno v: The Journal of Biological Chemistry
Background: CLEC-2 signals through a cytosolic YXXL downstream of a triacidic amino acid sequence (hemITAM). Results: We show a critical role for the triacidic amino acid in phosphorylation of the cytosolic tyrosine and that CLEC-2 signals via Syk bu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51524dc823bb3e2bd3b4c7533fba45bd
https://doi.org/10.1074/jbc.m112.411462
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3
A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase*
Autor: Marta I. Oliveira, Carine M. Gonçalves, Martina Bamberger, John R. James, Simon J. Davis, Ana Filipa L.O.M. Santos, Alexandre M. Carmo, Alexandra Moreira, Franscisco Lozano
Publikováno v: The Journal of Biological Chemistry
Triggering of the T cell receptor initiates a signaling cascade resulting in the activation of the T cell. These signals are integrated alongside those resulting from the triggering of other receptors whose function is to modulate the overall respons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0856d2270d532fa46514d76e81909ab9
http://europepmc.org/articles/PMC3162391
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4
Nephrocystin-4 Regulates Pyk2-induced Tyrosine Phosphorylation of Nephrocystin-1 to Control Targeting to Monocilia
Autor: Claudia Dafinger, Bernhard Schermer, Thomas Benzing, Roman U. Müller, Gerd Walz, Francesca Fabretti, Volker Burst, Andree Blaukat, Max C. Liebau, Martin Höhne, Matthias Hackl, Sibylle Zank, Hanswalter Zentgraf, Ingolf Schmedding, Benjamin Schairer, Sandra Habbig, Malte P. Bartram, Katja Höpker
Publikováno v: The Journal of Biological Chemistry
Nephronophthisis is the most common genetic cause of end-stage renal failure during childhood and adolescence. Genetic studies have identified disease-causing mutations in at least 11 different genes (NPHP1-11), but the function of the corresponding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27ba81e2c86e213b74ef919d5b7075f
https://doi.org/10.1074/jbc.m110.165464
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5
The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway *
Autor: Virginie Thomé, Anne-Catherine Lhoumeau, Laurent Kodjabachian, Sébastien Martinez, Pierluigi Scerbo, Avais M. Daulat, Jean-Paul Borg, Marilyn Giordano
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (51), pp.30562-30572. ⟨10.1074/jbc.M115.697615⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (51), pp.30562-72. ⟨10.1074/jbc.M115.697615⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, 2015, 290 (51), pp.30562-30572. ⟨10.1074/jbc.M115.697615⟩
Background: The planar cell polarity pathway plays important roles in morphogenetic processes. Results: PTK7 and ROR2 form a heterodimeric complex and bind to WNT5A, promoting JNK phosphorylation and regulating expression of paraxial protocadherin. C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ec7db2813ce4a0ab1d1c2f1a212282
https://hal.archives-ouvertes.fr/hal-01306990
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6
Akademický článek
Identification of Potential Antitubulin Agents with Anticancer Assets from a Series of Imidazo[1,2- a ]quinoxaline Derivatives: In Silico and In Vitro Approaches.
Autor: Goel, Kapil Kumar1,2 (AUTHOR), Hussain, Afzal3 (AUTHOR), Altamimi, Mohammad A.3 (AUTHOR) maltamimi@ksu.edu.sa, Rajput, Satyendra Kumar2 (AUTHOR), Sharma, Prince Prashant2 (AUTHOR), Kharb, Rajeev1 (AUTHOR) maltamimi@ksu.edu.sa, Mahdi, Wael A.3 (AUTHOR), Imam, Syed Sarim3 (AUTHOR), Alshehri, Sultan3 (AUTHOR), Alnemer, Osamah Abdulrahman3 (AUTHOR), Chaudhary, Anu4 (AUTHOR)
Publikováno v: Molecules. Jan2023, Vol. 28 Issue 2, p802. 14p.
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7
Akademický článek
Insights into Lipid-Based Delivery Nanosystems of Protein-Tyrosine Kinase Inhibitors for Cancer Therapy.
Autor: Jampilek, Josef1,2 (AUTHOR) josef.jampilek@gmail.com, Kralova, Katarina3 (AUTHOR)
Publikováno v: Pharmaceutics. Dec2022, Vol. 14 Issue 12, p2706. 31p.
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8
Akademický článek
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9
Akademický článek
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10
Akademický článek
Integrative Genomic Analysis Reveals Cancer-Associated Gene Mutations in Chronic Myeloid Leukemia Patients with Resistance or Intolerance to Tyrosine Kinase Inhibitor.
Autor: Wu, Waner (AUTHOR), Xu, Na (AUTHOR), Zhou, Xuan (AUTHOR), Liu, Liang (AUTHOR), Tan, Yaxian (AUTHOR), Luo, Jie (AUTHOR), Huang, Jixian (AUTHOR), Qin, Jiayue (AUTHOR), Wang, Juan (AUTHOR), Li, Zhimin (AUTHOR), Yin, Changxin (AUTHOR), Zhou, Lingling (AUTHOR), Liu, Xiaoli (AUTHOR)
Publikováno v: OncoTargets & Therapy. Aug2020, Vol. 13, p8581-8591. 11p.
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