Zobrazeno 1 - 10
of 3 856
pro vyhledávání: '"protein-trafficking"'
Autor:
Rebecca R. Pasquarelli, Justin J. Quan, Emily S. Cheng, Vivian Yang, Timmie A. Britton, Jihui Sha, James A. Wohlschlegel, Peter J. Bradley
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Toxoplasma gondii possesses a highly polarized secretory pathway that contains both broadly conserved eukaryotic organelles and unique apicomplexan organelles, which play essential roles in the parasite’s lytic cycle. As in other eukaryote
Externí odkaz:
https://doaj.org/article/bd70e26450dd4669976e1a1d2699ae14
Autor:
Nikita Shah, Ameya S. Kasture, Florian P. Fischer, Harald H. Sitte, Thomas Hummel, Sonja Sucic
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
As the first member of the solute carrier 6 (SLC6) protein family, the γ-aminobutyric acid (GABA) transporter 1 (GAT1, SLC6A1), plays a pivotal role in the uptake of GABA from the synaptic cleft into neurons and astrocytes. This process facilitates
Externí odkaz:
https://doaj.org/article/32a4d9eccf1a45ecadbc7b915b884790
Autor:
Jaime López-Alcalá, Ana Gordon, Andrés Trávez, Carmen Tercero-Alcázar, Alejandro Correa-Sáez, María Jesús González-Rellán, Oriol A. Rangel-Zúñiga, Amaia Rodríguez, Antonio Membrives, Gema Frühbeck, Rubén Nogueiras, Marco A. Calzado, Rocío Guzmán-Ruiz, María M. Malagón
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-28 (2024)
Abstract Background Excessive lipid accumulation in the adipose tissue in obesity alters the endocrine and energy storage functions of adipocytes. Adipocyte lipid droplets represent key organelles coordinating lipid storage and mobilization in these
Externí odkaz:
https://doaj.org/article/67e13ce9f2ae45388dd0b4f7ac1984d8
Publikováno v:
Plant Direct, Vol 8, Iss 6, Pp n/a-n/a (2024)
Abstract Eukaryotic cells are highly compartmentalized, requiring elaborate transport mechanisms to facilitate the movement of proteins between membrane‐bound compartments. Most proteins synthesized in the endoplasmic reticulum (ER) are transported
Externí odkaz:
https://doaj.org/article/7ee20ea152404f5f85155812b7a1acc5
Publikováno v:
Exploration of Medicine, Vol 4, Iss 5, Pp 695-708 (2023)
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the dep
Externí odkaz:
https://doaj.org/article/8e18e86db3e34e0e83f3ac44691853c3
Assessing the Presence of Phosphoinositides on Autophagosomal Membrane in Yeast by Live Cell Imaging
Publikováno v:
Microorganisms, Vol 12, Iss 7, p 1458 (2024)
The formation of autophagosomes mediating the sequestration of cytoplasmic materials is the central step of autophagy. Several phosphoinositides, which are signaling molecules on the membrane, are involved in autophagy. However, it is not always clea
Externí odkaz:
https://doaj.org/article/fd4974cbe6c74eb48adbf77ac04b33bd
Publikováno v:
Cells, Vol 13, Iss 13, p 1156 (2024)
Primary cilia are finger-like sensory organelles that extend from the bodies of most cell types and have a distinct lipid and protein composition from the plasma membrane. This partitioning is maintained by a diffusion barrier that restricts the entr
Externí odkaz:
https://doaj.org/article/9ac479bc39694045899a881c54839b29
Autor:
Yiqun Li, Mingrui Yang, Yanan Nan, Jiaming Wang, Sanjiao Wang, Dongxiao Cui, Jiajian Guo, Pengfei He, Wenxin Dai, Shuqi Zhou, Yue Zhang, Wenfu Ma
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 7, Pp 3043-3053 (2023)
Via an insufficient coat protein complex I (COPI) retrieval signal, the majority of SARS-CoV-2 spike (S) is resident in host early secretory organelles and a tiny amount is leaked out in cell surface. Only surface-exposed S can be recognized by B cel
Externí odkaz:
https://doaj.org/article/b65030a56221483b86fefa81f0fd510d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is a complex process that starts with its biosynthesis and folding in the endoplasmic reticulum. Exit from the endoplasmic reticulum (ER) is coupled with the acquis
Externí odkaz:
https://doaj.org/article/91e3cc2b6dc84b66b918b5ac5ff25bdc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In six basolater
Externí odkaz:
https://doaj.org/article/fadd5f5b3a004857bb715f6b4bc03be0